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中国癌症防治杂志

中国癌症防治杂志

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肝动脉化疗栓塞与静脉化疗治疗结直肠癌肝转移的疗效

水会锋;葛莲英;   

  1. 广西医科大学研究生学院;广西医科大学肿瘤医院;
  • 收稿日期:2010-03-25 修回日期:2010-03-25 出版日期:2010-03-25 发布日期:2010-03-25

Efficacy of transcatheter hepatic arterial chemoembolization and intravenous chemotherapy on patients with liver metastases from colorectal cancer

SHUI Hui-feng,GE Lian-ying .   

  1. (Graduate School of Guangxi Medical University,Tumor Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2010-03-25 Revised:2010-03-25 Online:2010-03-25 Published:2010-03-25

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被引次数

15

摘要： 目的通过比较TACE术与静脉化疗2种治疗方法对结直肠癌肝转移的近、远期疗效,从而探讨有效的治疗手段。方法回顾性分析自2002年1月至2008年12月在广西医科大学肿瘤医院进行TACE、静脉化疗治疗的62例结直肠癌肝转移患者,其中TACE组17例,静脉化疗组45例,对比其近期疗效和随访其生存状况。结果TACE组和静脉化疗组的近期有效率分别为64.7%、33.3%(P<0.05)。1年生存率分别为82.4%、59.6%;2年生存率分别为32.4%、19.3%;3年生存率分别为12.9%、7.4%;5年生存率均为0%(P均>0.05)。结论对于不能或不愿手术的结直肠癌肝转移病人,TACE术或静脉化疗是可选择的有效治疗方案。TACE术较静脉化疗在近期疗效上显示出一定的优势,但在延长生存期上则无差别。

关键词: 结直肠肿瘤, 肝转移, 肝动脉化疗栓塞, 化学治疗, 疗效

Abstract: Objective To analyze the efficacy of transcatheter hepatic arterial chemoembolization(TACE) and intravenous chemotherapy on liver metastases from colorectal cancer,by comparing short-and long-term therapeutic effect on the patients.Methods 62 patients with liver metastases from colorectal cancer were divided into two groups.17 patients who were treated by TACE were defined as TACE group,and the other group included 45 patients who received intravenous chemotherapy.The follow-up Results on therapeutic effect and survival rate from the two groups were compared.Results The short-term efficacy rate in TACE group was 64.7%,while it was 33.3% in intravenous chemotherapy group.The 1-,2-,3-and 5-year survival rates in the group of TACE were 82.4%,32.4%,12.9% and 0,versus 59.6%,19.3%,7.4% and 0 in the group of intravenous chemotherapy.Conclusions TACE and intravenous chemotherapy are effective,safe and alternative treatment for liver metastases from colorectal cancer in which the tumor can not be removed.Short-term therapeutic effect of TACE is better than that of intravenous chemotherapy,but the survival rates of the two treatments are similar.

Key words: Colorectal carcinoma, Hepatic metastasis, Transcatheter hepatic arterial chemoembolization, Chemotherapy