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中国癌症防治杂志

中国癌症防治杂志

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Herceptin联合化疗治疗Her-2过度表达的转移性乳腺癌的初步观察

韦劲松;李志革;宋向群;于起涛;曾爱屏;周达;何剑波;王惠临;宁瑞玲;   

  1. 广西医科大学肿瘤医院化疗科;
  • 收稿日期:2010-03-25 修回日期:2010-03-25 出版日期:2010-03-25 发布日期:2010-03-25

Preliminary observation of Herceptin-combined chemotherapy on Her-2 over-expressing metastatic breast cancer

WEI Jin-song,LI Zhi-ge,SONG Xiang-qun,et al.   

  1. (Department of Chemotherapy,Tumor Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2010-03-25 Revised:2010-03-25 Online:2010-03-25 Published:2010-03-25

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被引次数

19

摘要： 目的观察接受赫赛汀(Herceptin)联合异长春花碱(Vinorelbine,NVB)等药物治疗Her-2过度表达的转移性乳腺癌的疗效和毒副反应。方法20例予赫赛汀(Herceptin)的初始剂量为4mg/kg,以后每周1次,剂量为2mg/kg,至少6周。异长春花碱(NVB)25mg/m2,静脉点滴15min,d1,5;顺铂(DDP)20mg/m2,d1～3,静脉点滴;5-氟尿嘧啶(5-Fu)1.0g/d持续静脉点滴6～12h,d1～3。每21d为1周期。结果总有效率为70%(14/20),其中CR6例(30.0%),PR8例(40%)。中位生存期为14个月。主要毒性为Ⅲ～Ⅳ度粒细胞减少及继发性发热;仅1例观察到II度心脏毒性。结论Herceptin联合化疗作为Her-2过度表达的转移性乳腺癌的解救方案疗效显著,安全可靠。

关键词: 乳腺肿瘤, 药物治疗, Herceptin, 靶向治疗

Abstract: Objective To observe the effects and toxicity of Herceptin-combine Vinorelbine and other drug treatment on Her-2 over-expressing metastatic breast cancer.Methods Treatment consisted of Vinorelbine(25mg/m2 on day 1 and day 5 respectively),Trastuzumab(4mg/kg on day 0,followed by 2mg/kg weekly),Cisplantin(20mg/m2 on day 1~3) and Fluorouracil(1.0g on day 1~3).Results The overall response rate was 70%,including 6 cases(30%) complete and 8 cases(40%) partial response.Median survival was 15 months.Main toxicity was the degree III~IV of neutropenia(15/20) and secondary fever(6/15).Only one patient showed asymptomatic degree II of cardiac toxicity.Conclusion Herceptin-combined chemotherapy for treating Her-2 over-expressing metastatic breast cancer is safe and reliable,with significant efficacy.

Key words: Breast tumor, Chemotherapy, Herceptin, Targeted therapy