微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2021, Vol. 13 ›› Issue (4): 420-424.doi: 10.3969/j.issn.1674-5671.2021.04.16

• 临床研究 • 上一篇    下一篇

KIF20A在高级别T1膀胱癌组织中的表达及其预测术后复发的价值

  

  1. 湖南师范大学附属第一医院 湖南省人民医院泌尿外科 
  • 出版日期:2021-08-25 发布日期:2021-09-17
  • 通讯作者: 李嘉辉 E-mail：hhao79@126.com
  • 基金资助:
    湖南省自然科学基金项目（2015JJ2095）

Expression of KIF20A in T1 high⁃grade bladder cancer and its value in predicting postoperative recurrence

  • Online:2021-08-25 Published:2021-09-17

PDF (PC)

161

赞

摘要： 目的 探讨驱动蛋白家族成员 20A（KIF20A）蛋白在高级别T1（T1HG）膀胱癌组织中的表达及其预测术后复发的价值。方法 选取2013年8月—2015年12月于本院泌尿外科首次行经尿道膀胱肿瘤电切术切除患者的癌组织及其相应癌旁组织（距肿瘤边缘≥3 cm）标本94例，经术后病理诊断为T1HG膀胱癌。免疫组化法检测KIF20A 蛋白表达水平。术后通过膀胱镜监测肿瘤复发情况，采用Cox比例风险回归分析KIF20A 蛋白表达水平预测术后复发的价值。结果 TCGA数据库分析显示，膀胱癌患者癌组织中KIF20A mRNA表达量高于正常组织（P<0.05）；且KIF20A高表达组膀胱癌患者的无疾病进展生存率明显低于低表达组（P=0.012）。临床样本分析显示，与癌旁组织相比，T1HG膀胱癌组织中KIF20A蛋白阳性表达率升高(12.8% vs 64.9%，P<0.001)， KIF20A蛋白表达水平与年龄、吸烟史、肿瘤直径、T1亚分期、病理分级有关（均P<0.05）。KIF20A蛋白阳性表达组患者术后无复发生存时间较阴性表达组患者短（log-rank χ2=16.154，P<0.001）。多因素Cox比例风险回归显示， KIF20A蛋白阳性表达是患者术后复发的独立危险因素（OR=3.033，95%CI：1.451~6.339，P=0.003）。结论 KIF20A蛋白在T1HG膀胱癌组织中高表达，有望成为预测膀胱癌术后复发风险的有效生物学指标。

关键词: KIF20A, 高级别T1膀胱癌, 肿瘤复发, 临床病理特征

Abstract:  Objective To investigate the expression of kinesin family member 20A (KIF20A) in T1 high-grade (T1HG) bladder cancer tissues and its value in predicting postoperative recurrence. Methods A total of  94 tumor tissues and matched adjacent tissues (≥3 cm from the edge of the tumor) were selected from patients who underwent the first transurethral resection of bladder cancer in the department of urology of our hospital from August 2013 to December 2015, and the postoperative pathological diagnosis was T1HG bladder cancer. The expression of KIF20A protein was detected by immunohistochemistry. The recurrence of the tumor was monitored by cystoscopy, and the value of KIF20A protein expression in predicting postoperative recurrence was analyzed by Cox proportional hazard regression analysis. Results The TCGA database analysis showed that the expression of KIF20A mRNA in bladder cancer tissues was higher than that in normal tissues (P<0.05). Moreover, the disease-free progression rate of patients with bladder cancer in the high expression group of KIF20A was significantly lower than that in the low expression group (P=0.012). The analysis of clinical samples showed that the positive rate of KIF20A protein in T1HG bladder cancer tissues was significantly higher than that in adjacent tissues (12.8% vs 64.9%, P<0.001), and the expression level of KIF20A protein was correlated with age, smoking history, tumor diameter, T1 sub-stage and pathological grade (all P<0.05). Patients with KIF20A protein positive expression had shorter recurrence free survival than those with negative expression(log-rank χ2=16.154, P<0.001). The multivariable Cox proportional hazard regression analysis showed that the positive expression of KIF20A protein was an independent risk factor for postoperative recurrence (OR=3.033, 95%CI:1.451-6.339, P=0.003). Conclusions The KIF20A protein is highly expressed in T1HG bladder cancer tissues, and expected to be an effective biological indicator to predict the postoperative recurrence risk of T1HG bladder cancer.

Key words:  KIF20A, T1HG bladder cancer, Tumor recurrence, Cinicopathologic features

中图分类号: 

  • R737.14