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中国癌症防治杂志

中国癌症防治杂志 ›› 2025, Vol. 17 ›› Issue (2): 139-144.doi: 10.3969/j.issn.1674-5671.2025.02.02

• 癌情监测 • 上一篇    下一篇

肝癌早诊早治项目筛查与随访结果：基于广西扶绥县2011—2020年数据分析

  

  1. 广西医科大学附属肿瘤医院实验研究部;.扶绥县人民医院预防保健科
  • 出版日期:2025-04-25 发布日期:2025-05-15
  • 通讯作者: 黄天壬 E-mail：tianrenhuang@sina.com
  • 基金资助:
    国家自然科学基金项目（82160638）

Screening and follow-up results of the early diagnosis and treatment program for liver cancer: a data analysis based on Fusui County, Guangxi, 2011—2020

  • Online:2025-04-25 Published:2025-05-15

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摘要： 目的 分析2011—2020年广西扶绥县肝癌早诊早治项目的筛查及随访结果。 方法 采用分层整群抽样方法，选取2011—2020年广西扶绥县35~64岁男性、45~64岁女性居民以及不在该年龄范围内但直系亲属有肝癌病例者的居民为研究对象。通过问卷调查及乙型肝炎表面抗原（hepatitis B surface antigen，HBsAg）检测确定肝癌高危人群，并对高危人群进行肝脏B超和甲胎蛋白（alpha fetoprotein，AFP）联合筛查。分析肝癌早诊早治项目筛查的顺应性（筛查参与率）、检出率、早诊率、治疗率及生存预后。结果 2011—2020年广西扶绥县共评估出肝癌高危人群27 613人，其中完成肝癌联合筛查14 012人，筛查参与率为50.74%。确诊肝癌120例，检出率为0.86%,其中男性肝癌检出率明显高于女性（1.12% vs 0.51%, P<0.001）。35~44岁、45~54岁和≥55岁年龄段的肝癌检出率分别为0.67%、0.92%和1.05%，但差异无统计学意义（P=0.169）。120例肝癌患者中，早诊率为60.83% (73/120)，治疗率为91.67% (110/120)；所有患者的1、3及5年生存率分别为66.67%、33.33%和20.83%，其中早期肝癌患者的1、3及5年生存率分别为75.34%、36.99%和24.66%。 结论 扶绥县开展肝癌早诊早治项目筛查工作能有效检出肝癌患者，早期发现癌变，从而及早采取治疗措施，延长患者生存时间。

关键词: 肝癌, 早诊早治, 筛查, 广西

Abstract: Objective To analyze the screening and follow⁃up outcomes of liver cancer early diagnosis and treatment program in Fusui County, Guangxi, from 2011 to 2020. Methods A stratified cluster sampling method was employed to enroll the residents aged 35-64 years old for male and 45-64 years old for female， and other residents who were not within this age range but had cases of liver cancer in their immediate family members in Fusui County from 2011 to 2020 as the study subjects. High⁃risk populations of liver cancer were identified through questionnaires and hepatitis B surface antigen (HBsAg) testing. These individuals underwent combined screening via liver ultrasound and alpha fetoprotein (AFP) testing. The compliance of participating in the early diagnosis and treatment of liver cancer program was analyzed, as well as the detection rate, early diagnosis rate, treatment rate and prognosis of liver cancer. Results From 2011 to 2020, a total of 27, 613 high⁃risk groups were assessed in Fusui County, Guangxi, of which a total of 14, 012 people completed combined screening for liver cancer, with a screening participation rate of 50.74%; 120 liver cancer cases were found and diagnosed, with a detection rate of 0.86%. The detection rate of liver cancer in males was significantly higher than that in females (1.12% vs 0.51%, P<0.001). The detection rates of liver cancer in the age groups of 35-44 years old, 45-54 years old, and ≥55 years old were 0.67%, 0.92%, and 1.05%, respectively, and the difference was not statistically significant (P=0.169). Among the 120 cases of liver cancer , the early diagnosis and treatment rates were 60.83% (73/120) and 91.67% (110/120) respectively. Overall 1⁃, 3⁃, and 5⁃year survival rates were 66.67%, 33.33%, and 20.83%, respectively, while early⁃state liver cancer survival rates were 75.34%, 36.99%, and 24.66%, respectively. Conclusions The early diagnosis and treatment program in Fusui County can effectively identifies liver cancer cases, enables timely intervention, and prolongs survival through early diagnosis.

Key words: Liver cancer, Early diagnosis and treatment, Screening, Guangxi 

中图分类号: 

  • R735.7