微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志

• 论文 • 上一篇    下一篇

survivin和bcl-2蛋白在宫颈病变中的表达及其意义

梁莹莹;李琦;李晶;   

  1. 广州市番禺中心医院超声科;广州市番禺中心医院病理科;
  • 收稿日期:2010-09-25 修回日期:2010-09-25 出版日期:2010-09-25 发布日期:2010-09-25

Expressions and significances of survivin and bcl-2 in cervical lesions

LIANG Ying-ying, LI Qi, LI Jing   

  1. (Department of Ultrasound,Department of Pathology, Panyu Central Hospital, Guangzhou 514000, China
  • Received:2010-09-25 Revised:2010-09-25 Online:2010-09-25 Published:2010-09-25

赞

被引次数

15

摘要： 目的探讨survivin和bcl-2在宫颈鳞癌组织、CIN和正常宫颈组织中的表达及意义。方法采用免疫组化Envision法检测survivin和bcl-2在50例宫颈癌、20例CINⅠ级、20例CINⅡ～Ⅲ级及20例正常宫颈组织中的表达,分析其与不同宫颈病变的关系。结果 survivin和bcl-2的阳性率在宫颈癌组织中远高于CIN和正常宫颈组织,差异有统计学意义(P<0.05),但在不同组织学分级的宫颈癌中表达差异无统计学意义(P>0.05)。结论 survivin和bcl-2蛋白的异常表达与宫颈癌的发生密切相关,可为临床筛查宫颈癌及判断预后提供新的依据和诊断指标。

关键词: survivin, bcl-2, 宫颈癌, 免疫组化

Abstract: Objective To investigate the expressions and significances of survivin and bcl-2 in cervical carcinoma, CIN and normal cervical epithelial tissues.Methods Immunohistochemical staining was used to examine the expressions of survivin and bcl-2 in 50 cases of cervical carcinoma, 20 cases of CIN I,20 cases of CIN II~III and 20 cases of normal cervical epithelial tissues.Results The expressions of survivin and bcl-2 in carcinoma were stronger than that in CIN and normal cervical epithelial tissues (P<0.05), while there was no significant difference among different degrees of cervical carcinoma.Conclusion The expression of survivin and bcl-2 are closely related to carcinogenesis of cervix.

Key words: survivin, bcl-2, Cervical carcinoma, Immunohistochemical staining