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中国癌症防治杂志

中国癌症防治杂志

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VEGF阳性表达与肝癌术后复发相关性的研究

莫显伟;林源;   

  1. 广西贵港市人民医院普外科;广西医科大学肿瘤医院;
  • 收稿日期:2009-09-25 修回日期:2009-09-25 出版日期:2009-09-25 发布日期:2009-09-25

Relationship between expression of VEGF and recurrence of Hepatocellular Carcinoma

1MO Xian-wei,2LIN Yuan   

  1. (1People's Hospital of Guigang City,Guangxi 537100;2Cancer Hospital of Guangxi Medical University;Guangxi 530021,China
  • Received:2009-09-25 Revised:2009-09-25 Online:2009-09-25 Published:2009-09-25

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被引次数

23

摘要： 目的探讨血管内皮细胞生成因子(VEGF)阳性表达与肝细胞肝癌(HCC)复发的相关性。方法将71例肝癌患者根据VEGF表达分成VEGF阳性表达组(VP)34例及VEGF阴性表达组(VN)37例,比较两组患者的肿瘤细胞分级、肿瘤包膜、静脉癌栓、1年复发率及大于1年小于3年的复发率。结果两组病例在肿瘤细胞分级及大于1年小于3年复发率比较差异无统计学意义(P>0.05);VP组静脉癌栓率及1年复发率明显高于VN组(P<0.05),VP组有完整肿瘤包膜率明显低于VN组(P<0.05)。结论VEGF表达与肝癌复发相关性可能是通过产生微转移灶的作用形成肝癌的早期复发灶,而与肝癌的晚期复发则无明显相关性。

关键词: 血管内皮细胞生成因子, 肝细胞肝癌, 复发

Abstract: Objective To explore the relationship between expression of vascular endothelial growth factor(VEGF) and recurrence of hepatocellular carcinoma(HCC).Methods 71 cases of patients with HCC were grouped into VEGF-positive expression(VP) and VEGF-negative expression(VN).Parameters from the two groups such as classification of cancer cells,tumor capsule,vein tumor thrombus,recurrence rate in 1 year and recurrence rate between 1 and 3 years were compared.Results There were no significant differences between the two groups at classification of cancer cells and recurrence rate between 1 and 3 years(P>0.05).The rate of vein tumor thrombus and recurrence rate in 1 year were higher in group VP than that in group VN(P<0.05).The rate of tumor capsule was lower in group VP than that in group VN(P<0.05).Conclusions Expression of VEGF is correlated with early recurrence of HCC,possibly through the role of micro-metastasis by cancer cells.Expression of VEGF is not significantly correlated with the late recurrence of HCC.

Key words: Vascular endothelial growth factor, Hepatocellular carcinoma, Recurrence