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中国癌症防治杂志

中国癌症防治杂志

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hOGG1在原发性肝癌和肝硬化组织中的表达及意义

苏智雄;黎乐群;彭涛;叶新平;肖开银;尚丽明;   

  1. 广西医科大学第一附属医院肝胆外科;
  • 收稿日期:2009-03-25 修回日期:2009-03-25 出版日期:2009-03-25 发布日期:2009-03-25

The implications of hOGG1 expression in hepatocellular carcinoma and cirrhosis tissues

SU Zhi-xiong,LI Le-qun,PENG Tao,et al.   

  1. (The First Affiliated Hospital,Guangxi Medical University,Nanning Guangxi 530021,China
  • Received:2009-03-25 Revised:2009-03-25 Online:2009-03-25 Published:2009-03-25

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被引次数

1

摘要： 目的通过检测DNA修复酶hOGG1在原发性肝癌(hepatocellular carcinoma,HCC)及肝硬化组织中的表达,探讨hOGG1在HCC和肝硬化组织中的表达特点及其与临床病理因素的关系。方法应用EnVision免疫组化法检测41例非HCC正常肝组织、99例HCC、51例HCC癌旁肝硬化组织中hOGG1表达情况。结果在HCC组织中hOGG1在细胞核与细胞质中均可表达,其中hOGG1细胞核阳性分度在正常组、肝硬化组、HCC组之间依次增高(P<0.001)。多因素分析显示hOGG1蛋白在细胞核表达与ALT有关(OR=1.022,P=0.041),hOGG1蛋白在细胞浆表达与总胆红素有关(OR=1.155,P=0.018)。结论在HCC发生过程中hOGG1蛋白在肝细胞核中的表达可能随着病程进展而增强,反映了从肝硬化到肝癌进程中肝细胞内氧化应激状态的改变。

关键词: hOGGl, 原发性肝癌

Abstract: Aim:To explore the expression and its clinicopathological implications of human 8-oxoGuanine DNA glycosylase-1 (hOGG1) in hepatocellular carcinoma(HCC) and cirrhotic tissues.Methods:hOGG1 expression was detected by immuneohistochemical EnVision method on liver tissues of non-HCC controls(n =41),cirrhotic(n =51) and HCC tissues(n =99 ).Results: There were three types of hOGG1 positive staining in HCCs:nuclear,cytoplasmic and mixed.The expression levels of hOGG1 in nucleus was significantly higher in HCCs than that in cirrhosis and controls and significantly higher in cirrhosis than that in controls(P<0.01).The expression of hOGG1 was not associated with the clinicopathological factors in HCCs(P>0.05 ).Multiplicity analysis indicated that hOGG1 expression in nucleus was related to ALT(OR = 1.022,P = 0.041),hOGG1 expression in cytoplasm was related to T bili(OR = 1.155,.P = 0.018).Conclusion:During hepatocarcinogenesis,the expression pattern of hOGG1 in liver cell nucleus might reflect the status of oxidative stress in each stage thus has etiology implications.

Key words: Human 8-oxoGuanine DNA glycosylase-1(hOGG1), Hepatocellular carcinoma, Immunohistochemistry