微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2020, Vol. 12 ›› Issue (5): 572-577.doi: 10.3969/j.issn.1674-5671.2020.05.16

• 临床研究 • 上一篇    下一篇

TACE 术前天冬氨酸氨基转移酶与淋巴细胞比值对原发性肝癌并门脉癌栓患者预后预测的价值

  

  1. 广西医科大学研究生院；广西医科大学基础医学院；广西医科大学附属肿瘤医院肝脏胰腺外科；广西医科大学区域性高发肿瘤重点实验室；广西壮族自治区民族医院
  • 出版日期:2020-10-25 发布日期:2020-10-25
  • 通讯作者: 王小波 Ｅ-ｍａｉｌ：82751164@qq.com
  • 基金资助:
     国家自然科学基金项目（81860502）；广西科技计划项目（桂科AA18221001）；广西高校中青年教师科研基础能力提升项目（2019KY0139）

Value of the aspartate aminotransferase to lymphocyte ratio in evaluating prognosis of primary liver cancer with portal vein tumor thrombus patients before TACE

  1. Guangxi Medical University Graduate School; Guangxi Medical University First Clinical Medical College; Department of Liver and Pancreas Surgery, Guangxi Medical University Cancer Hospital; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education; Minzu Hospital of Guangxi Zhuang Autonomous Region
  • Online:2020-10-25 Published:2020-10-25
  • Contact: WANG Xiaobo E-mail: 82751164@qq.com

PDF (PC)

202

赞

摘要： 目的 探讨肝动脉化疗栓塞（transcatheter arterial chemoembolization，TACE）术前天冬氨酸氨基转移酶与淋巴细胞比值（aspartate aminotransferase to lymphocyte ratio index，ALRI）在原发性肝癌并门脉癌栓（primary liver cancer-portal vein tumor thrombosis，PLC-PVTT）患者预后预测中的价值。方法 选取2013年11月21日至2018年8月22日于广西医科大学附属肿瘤医院接受TACE治疗的175例PLC-PVTT患者为研究对象。采用时间依赖性ROC曲线确定ALRI的最佳临界值。采用Cox 回归模型分析总生存期（overall survival，OS）的独立预测因素，Kaplan-Meier法计算生存率。结果 ROC曲线显示，ALRI的最佳临界值为49.37，对应曲线下面积为0.71。Kaplan-Meier分析显示，ALRI>49.37的患者OS较ALRI≤49.37的患者短（P=0.003）。Cox 回归分析结果显示，ALRI>49.37、行1次以上TACE治疗、Child-Pugh分级B级、凝血酶原时间≥13 s是患者TACE术后OS的独立危险因素（均P＜0.05）。结论 TACE术前ALRI>49.37是PLC-PVTT患者OS的独立危险因素。

关键词: 原发性肝癌, 门静脉癌栓, 肝动脉化疗栓塞, 天冬氨酸氨基转移酶, 淋巴细胞, 预后

Abstract: Objective To investigate the value of the aspartate aminotransferase to lymphocyte ratio (ALRI) in the prognosis evaluation of primary liver cancer(PLC) with portal vein tumor thrombosis(PVTT) patients before transcatheter arterial chemoembolization (TACE). Methods A total of 175 patients with PLC and PVTT who received TACE treatment in Guangxi Medical University Cancer Hospital from June 2013 to June 2018 were selected. The optimal critical value of ALRI was determined by the time-dependent ROC curve, the independent predictors of overall survival(OS) were analyzed by Cox regression model, and the survival rate was calculated by Kaplan-Meier method. Results The ROC curve showed that the optimal clinical value of ALRI was 49.37, and the corresponding AUC was 0.71. Kaplan Meier analysis showed that the OS of patients with ALRI>49.37 was shorter than that of patients with ALRI≤49.37(P=0.003). Cox regression analysis showed that ALRI>49.37, more than one TACE treatment, Child-Pugh grade B, and prothrombin time≥13 s were among the independent risk factors for OS in PVTT patients after TACE (all P<0.05). Conclusion ALRI>49.37 before TACE is an independent risk factor for OS in patients with PLC-PVTT.

Key words: Primary liver cancer, Portal vein tumor thrombosis, Transcatheter arterial chemoembolization, Aspartate aminotrans-ferase, Lymphocyte, Prognosis

中图分类号: 

  • R735.7