微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志

• 论文 • 上一篇    下一篇

卵巢上皮癌术后化疗期间血清CA_(125)检测与其预后关系的研究

唐勇;李力;唐兆前;梁霞;张玮;   

  1. 广西医科大学附属肿瘤医院;广西医科大学研究生学院;
  • 收稿日期:2009-03-25 修回日期:2009-03-25 出版日期:2009-03-25 发布日期:2009-03-25

Study on the relationship between serum CA_(125) of postoperative chemotherapy and prognosis of epithelial ovarian carcinoma

TANG Yong,LI Li,TANG Zhao-qian,et al.   

  1. (The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2009-03-25 Revised:2009-03-25 Online:2009-03-25 Published:2009-03-25

赞

摘要： 目的探讨术后3疗程化疗后血清CA_(125)不同的界值对卵巢上皮癌预后评估的意义。方法对我院妇泌科自1998年1月1日至2002年12月30日期间收治的94例术后行6～8疗程化疗的卵巢上皮癌患者,在化疗3个疗程后进行血清CA_(125)测定。血清CA_(125)分别以正常值(35U/ml)、正常值的2倍(70U/ml)和3倍(105U/ml)为界值,以累积生存率和平均生存期为参数,绘制Kaplan-Meier生存曲线,log-rank test法作预后分析。结果术后3疗程化疗后血清CA_(125)≤35U/ml和CA_(125)>35U/ml患者累积生存率相比较,差异无统计学意义(P=0.0693);术后3疗程化疗后CA_(125)≤70U/ml的患者的累积生存率与CA_(125)>70U/ml组比较,差异无统计学意义(P=0.1074);术后3疗程化疗后CA_(125)≤105U/ml的患者累积生存率较CA_(125)>105U/ml的患者高(P=0.0171)。结论术后化疗3疗程后血清CA_(125)以105U/ml为界值对卵巢上皮癌的预后评定有一定的临床价值,检测该指标对上皮性卵巢癌的预后有一定的指导作用。

关键词: 卵巢上皮癌, CA_(125), 预后

Abstract: Objective To investigate the significance of serum CA_(125) value taken after 3 cycle postoperative chemotherapy for evaluating the prognosis of epithelial ovarian carcinoma.Methods Serum CA_(125) after 3 cycle chemotherapy from 94 patients with epithelial ovarian carcinoma treated by operation and 6～8 cycle chemotherapy were detected,during the period from Jan.1, 1998 to Dec.30,2002 in our department.The patients were divided into three groups according to their serum CA_(125) concentration such as normal value(35U/ml),two fold of normal value(70U/ml) and three fold of value(105U/ml),respectively. Accumulated survival rate and average survival time were estimated using Kaplan-Meier estimates and compared with the logrank test where indicated.Results Accumulated survival rate of patients whose 3 cycle postoperative chemotherapy serum CA_(125) were≤35U/ml had no significant difference(P = 0.0693) from that of CA_(125)>35U/ml.There was no significant difference(P = 0.1074) between the group of CA_(125)≤70U/ml and>70U/ml as well.Accumulated survival rate of patients whose 3 cycle postoperative chemotherapy serum CA_(125)≤105 U/ml was significantly higher than those whose CA_(125)>105U/ml(P = 0.0171). Conclusions 105U/ml of CA_(125) after 3 cycle postoperative chemotherapy could be applied to evaluate prognosis of epithelial ovarian carcinoma.

Key words: Epithelial ovarian carcinoma, CA_(125), Prognosis