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中国癌症防治杂志

中国癌症防治杂志

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原发性肝癌介入治疗的临床分析

章阳;马亦龙;康平;齐锋;崔英;   

  1. 广西医科大学肿瘤医学院;
  • 收稿日期:2009-03-25 修回日期:2009-03-25 出版日期:2009-03-25 发布日期:2009-03-25

Clinical Analysis of Interventional Procedure in Primary Hepatic Cancer

ZHANG Yang,MA Yi-long,KANG Ping,et al.   

  1. (Tumor Medical Colloge of Guangxi Medical University,Nanning 530021,China
  • Received:2009-03-25 Revised:2009-03-25 Online:2009-03-25 Published:2009-03-25

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被引次数

4

摘要： 目的比较TACE、TACE+PEI及PEI 3种介入治疗方案对原发性肝癌的疗效,综合分析预后影响因素,为治疗方案的制定、提高介入治疗疗效及预后的估计提供理论依据。方法回顾性分析98例进行TACE、PEI或TACE+PEI介入治疗方案治疗的PLC病例,对影响肝癌治疗及预后的相关因素行Cox回归分析。结果3组中以TACE+PEI组疗效最好,生存率最高,中位生存期最长;AFP改善以及肝功能分级改善情况亦以TACE+PEI组为最佳。Cox回归单因素分析显示,对预后有显著影响的因素为癌栓、肿瘤缩小率、TACE+PEI治疗及治疗后AFP值;多因素分析示癌栓、TACE+PEI治疗对预后有意义。结论TACE+PEI疗效显著,治疗后AFP及肝功能改善情况显著优于单纯TACE或PEI方案,明显延长患者生存期。门静脉癌栓形成是影响肝癌介入治疗患者预后的重要危险因素;无癌栓、行TACE+PEI治疗者的生存期长。

关键词: 原发性肝癌, 介入治疗, 临床分析

Abstract: Objective By comparing interventional treatments TACE,TACE + PEI and PEI for primary liver cancer(PLC) and comprehensivly analysing major factors which influenced prognosis,to provide a theory-based evidence for the formulation of treatment plan,the effects of interventional treatment and the estimation of prognosis.Methods 98 PLC patients treated with TACE,PEI or TACE + PEI were studied retrospectively.Cox regression analysis was used for the impact on treatment and prognostic of liver cancer-related factors.Results Of the three groups,TACE + PEI group obtained the best curative effect,the highest survival rate and the longest middle life span.The best achievement on reducing AFP value and the improvement of liver functional also happened in TACE + PEI group.Cox regression simplex factor analysis showed that the significantly influential factors were carcinoma embolus,tumour diminution rate,TACE + PEI treatment and AFP value of post-treatment Multiplicity factor analysis showed that carcinoma embolus and TACE + PEI treatment were the factors make sense to prognosis.Conclusion TACE + PEI treatment has notably curative effect With TACE + PEI treatment,the decrease of AFP value after treatment and the improvement of liver function on paients also obviously better than teated with either TACE or PEI.Besides,this treatment can prolong sufferers life span notably.The formation of carcinoma embolus in portal vein is the the most important risk factor to impact prognosis of patients suffered PLC with interventional treatment.Paients without carcinoma embolus and given TACE + PEI treatment have longer life span.

Key words: Primary liver cancer, Interventional procedure, Clinical analysis