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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (2): 133-.doi: 10.3969/j.issn.1674-5671.2011.02.10

• 临床研究 • 上一篇    下一篇

非小细胞肺癌6MV-X射线和10MV-X射线调强放射治疗计划的剂量学比较

王磊黎, 梁世雄, 韦军葆, 付庆国, 邓 烨   

  • 出版日期:2011-08-03 发布日期:2011-08-03

WANG Lei-Li, LIANG Shi-Xiong, WEI Jun-Bao, FU Qing-Guo, DENG Ye   

  • Online:2011-08-03 Published:2011-08-03

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被引次数

7

摘要： 【摘要】目的 比较非小细胞肺癌（NSCLC）调强放射治疗（IMRT)计划中采用6MV-X和10MV-X射线治疗的剂量学差异。方法 应用ADAC Pinnacle8治疗计划系统提供的卷积/迭加法对两种能量条件下相同靶区的IMRT计划进行剂量计算，通过剂量-体积直方图(DVH)参数（最大剂量、平均剂量和处方剂量）、均匀性指数（HI）以及适形指数（CI），比较8例肺癌患者的6MV-X和10MV-X射线的IMRT计划的物理学参数。结果两者靶区的平均剂量、HI和CI之间差异比较无明显统计学差异，但6MV计划中高剂量覆盖靶区的程度优于10MV计划；正常肺组织、心脏、脊髓等危及器官(OAR)的受量基本相同。结论对于肺癌的放射治疗建议选用6MV-X射线。

关键词: 【关键词】调强放射治疗, 非小细胞肺癌, 剂量均匀性, 适形指数

Abstract: 【Abstract】Objective To compare the effects of 6MV and 10MV X-ray intensity modulated radiotherapy (IMRT) on non-small-cell lung cancer (NSCLC)Methods 6MV and 10MV X-ray IMRT plans were performed on 8 patients with NSCLC. The doses of the two identical planning objectives of IMRT were calculated by convolution/superposition algorithm provided by ADAC treatment planning system. Plans were compared according to dose-volume histogram (DVH) analysis，including conformity and homogeneity indices (CI and HI). Results Between 6MV and 10MV X-ray plan，the differences of the average garget dose，HI and CI were not statistically significant (P＞0.05)，but the degree of target coverage in high dose of 6MV plan was better than that in 10MV plan. Conclusions 6MV X-ray plan may be the better choice of radiotherapy on NSCLC.

Key words: 【Key words】Intensity modulated radiotherapy, Non-small-cell lung cancer, Dose homogeneity, Conformity index