微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (3): 238-240.doi: 10.3969/j.issn.1674-5671.2011.03.16

• 临床研究 • 上一篇    下一篇

V20、MLD与放射性肺损伤的相关性研究

蒋雪超, 崔洪霞, 宋红强   

  1. 山东滨州滨州市中心医院肿瘤科
  • 出版日期:2011-09-25 发布日期:2011-10-17
  • 通讯作者: 蒋雪超 E-mail:bzjfjxc@163.com

Relation of V20 and MLD to radiationinduced lung injury

JIANG Xue-Chao, CUI Hong-Xia, SONG Hong-Qiang   

  • Online:2011-09-25 Published:2011-10-17
  • Contact: JIANG Xue-Chao E-mail:bzjfjxc@163.com

PDF (PC)

676

赞

摘要： 目的 研究V20、MLD与放射性肺损伤发生的相关性，指导临床放疗计划的制定，避免或减少放射性肺损伤，提高局部控制率，改善患者生存质量。方法 自2008年8月至2010年6月，47例符合研究条件的肺癌患者入组。所有患者均接受三维适形放疗，应用6MV X-线照射，剂量50~70Gy/25~35f。制定放疗计划，生成剂量-体积直方图（DVH），得到物理参数V20及MLD，分析以上参数及其他临床因素对放射性肺损伤的影响，放疗计划要求V20≤30%，脊髓总量≤45Gy。放疗结束后定期行胸片及CT复查，根据辅助检查结果及临床表现诊断放射性肺损伤的发生，依据RTOG分级标准评价放射性肺损伤的程度。结果 47例中有15例发生放射性肺损伤，放射性肺损伤发生率为31.9%（15/47）。当V20≤25%和＞25%时，放射性肺损伤发生率分别为14.3%和46.2%，差异有统计学意义﹙P＜0.05﹚。当MLD≤15Gy和＞15Gy时，放射性肺损伤发生率分别为14.3%和57.9%，差异有统计学意义﹙P＜0.05﹚。结论 V20、MLD与放射性肺损伤有相关性，对预测放射性肺损伤有一定价值。

关键词:  放射性肺损伤, 肺癌, V20, MLD

Abstract: Objective To investigate the relation of V20 and MLD to radiation-induced lung injury.Methods From Aug 2008 to Jun 2010，47 patients with lung cancer and met the study criteria were enrolled. All patients receive 3D conformal radiotherapy by 6MVX-ray，and the doses ranged between 50Gy to 70Gy. DVH was gained through 3-dimensional TPS. The radiation treatment planning was V20 ≤ 30% and the spinal cord volume was≤45Gy. Radiation-induced lung injury was diagnosed based on contrasted CT combined with clinical symptoms，and the extent of injury was evaluated according to RTOG grading criteria.Results The total incidence of radiation-induced lung injury was 31.9% (15/47). While the incidence of lung injury was higher in the group of V20＞25% (46.2%) than that in the group of V20≤25% (14.3%，P＜0.05)The incidence of lung injury was lower in the group of MLD≤15Gy (14.3%) than that in the group of MLD＞15Gy (57.9%，P＜0.05).  Conclusion The radiation-induced lung injury related significantly to V20 and MLD that could help to predict the injury.

Key words: Radiation-induced lung injury, Lung cancer, V20, MLD