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中国癌症防治杂志

中国癌症防治杂志 ›› 2014, Vol. 6 ›› Issue (1): 43-47.doi: 10.3969/j.issn.1674-5671.2014.01.10

• 临床研究 • 上一篇    下一篇


Ku70和端粒酶及端粒酶逆转录酶预测直肠癌新辅助放化疗的疗效

  

  1. 广西医科大学附属肿瘤医院胃肠外科；广西医科大学研究生学院
  • 出版日期:2014-03-25 发布日期:2014-04-10
  • 通讯作者: 覃宇周 E-mail:qyz402@126.com
  • 基金资助:

    广西教育厅科研基金资助项目［200911MS29］

Ku70，telomerase and hTERT as novel predictors of sensitivity to neoadjuvant chemoradiotherapy to treat rectal cancer

  • Online:2014-03-25 Published:2014-04-10

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摘要： 目的 研究Ku70、端粒酶（telomerase）及端粒酶逆转录酶（hTERT） 3种蛋白预测Ⅱ期和Ⅲ期直肠癌放疗联合XELOX方案化疗的疗效。方法 根据新辅助放化疗前后影像学检查的疗效评价，将入组患者分为有效组27例和无效组18例；采用免疫组化SP法检测两组患者新辅助放化疗前后Ku70、端粒酶及hTERT 蛋白的表达情况，并分析其与疗效的关系。结果 有效组患者hTERT蛋白的表达水平比无效组低，差异具有统计学意义（P<0.05）。Ku70、端粒酶蛋白在有效组与无效组患者中的表达水平差异无统计学意义（P>0.05）。Ku70、 端粒酶及hTERT蛋白的表达水平在放化疗前后的差异有统计学意义（P<0.05）。直肠癌患者新辅助放化疗的疗效与患者KPS评分、性别、年龄和病理类型等无关（P>0.05）。结论 hTERT蛋白的表达可以反映Ⅱ期和Ⅲ期直肠癌患者予放疗联合XELOX方案化疗的新辅助放化疗的疗效。

关键词: 直肠肿瘤, Ku70, 端粒酶, 端粒酶逆转录酶, 新辅助放化疗, 疗效

Abstract: Objective To correlate the efficacy of neo-adjuvant chemoradiotherapy in phase Ⅱ and Ⅲ rectal cancer patients with expression of Ku70，telomerase and hTERT proteins. Methods Expression levels of Ku70，telomerase and hTERT were analyzed by immunohistochemistry in rectal cancer patients who responded effectively to neoadjuvant chemoradiotherapy（XELOX regimen，n=27） and in patients in whom such therapy was ineffective（n=18）.Levels in the two groups were compared before and after neoadjuvant chemoradiotherapy. Results Expression of hTERT was significantly lower in patients who responded effectively to therapy than in those who did not（P<0.05）.The two patient groups showed similar expression of Ku70 and telomerase（P>0.05）.In each of the patient groups， expression levels of hTERT， telomerase and Ku70 differed significantly before and after chemoradiotherapy （P<0.05）.Efficacy of neoadjuvant chemoradiotherapy did not correlate with sex， age， pathological type or KPS score（P>0.05）. Conclusion Expression of hTERT in phase Ⅱ and Ⅲ rectal cancer patients may correlate with the efficacy of neoadjuvant chemotherapy combined with radiotherapy.

Key words:  Rectal neoplasm, Ku70, Telomerase, hTERT, Neoadjuvant chemoradiotherapy, Efficacy