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中国癌症防治杂志

中国癌症防治杂志 ›› 2014, Vol. 6 ›› Issue (2): 138-142.doi: 10.3969/j.issn.1674-5671.2014.02.08

• 临床研究 • 上一篇    下一篇

FKBP12和FKBP52在肝细胞癌中的表达及临床意义

  

  1. 广西医科大学研究生学院；广西医科大学第一附属医院肝胆外科
  • 出版日期:2014-06-25 发布日期:2014-07-08
  • 通讯作者: 徐 静 E-mail:jxuapr@aliyun.com
  • 基金资助:

     国家自然科学基金资助项目（81360372）；广西卫生厅中医药管理局科研基金资助项目（GZKZ10-114）

Expression and clinical significance of FKBP12 and FKBP52 in primary hepatocellular carcinoma

  • Online:2014-06-25 Published:2014-07-08

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被引次数

8

摘要： 目的 分析FKBP12和FKBP52在肝细胞癌（hepatocellular carcinoma，HCC）组织中的表达，并探讨其与HCC临床病理因素的关系。方法 应用免疫组化SP法检测FKBP12和FKBP52在60例HCC组织、60例癌旁组织、10例肝血管瘤组织和10例正常肝组织中的表达水平，并结合临床病理因素分析其临床意义。结果 在HCC组织、癌旁组织、肝血管瘤组织和正常肝组织中FKBP12的阳性表达率分别为66.7%、30.0%、20.0%和40.0%，FKBP12在HCC组织中的表达明显高于癌旁组织、肝血管瘤组织和正常肝组织中的表达（P均＜0.05）。在HCC组织、癌旁组织、肝血管瘤组织和正常肝组织中FKBP52的阳性表达率分别为63.3%、26.7%、40.0%和20.0%，FKBP52在HCC组织中的表达明显高于癌旁组织和正常肝组织中的表达（P均＜0.05），与肝血管瘤组织中的表达比较差异无统计学意义（P＞0.05）。FKBP12和KBP52在HCC组织中的表达比较差异无统计学意义（P＞0.05）。FKBP12在HCC组织中的表达水平与患者年龄、性别、合并肝硬化和乙肝病毒感染无明显关系（P均＞0.05），而与肿瘤直径、病理分级和血清中AFP的水平有关（P均＜0.05）。FKBP52在HCC组织中的表达水平与患者年龄、性别、肿瘤直径、合并肝硬化和血清中AFP的水平无明显关系（P均＞0.05），而与病理分级、乙肝病毒感染有关（P均＜0.05）。结论 FKBP12和FKBP52的高表达与HCC的发生、发展密切相关。FKBP12可能参与HCC癌细胞的增殖以及分化过程，并且可能与HCC患者血清中AFP水平的升高有关；FKBP52可能参与HCC的分化过程，并且可能与乙肝病毒感染密切相关。

关键词: 肝肿瘤, 肝细胞癌, FKBP12, FKBP52, 免疫组织化学

Abstract: Objective To analyze the expression of FKBP12 and FKBP52 in hepatocellular carcinoma（HCC） and explore its rela-tionship with clinicopathological factors. Methods Expression of FKBP12 and FKBP52 was measured in 60 samples of HCC tissue， 60 samples of normal adjacent tissue，10 samples of hepatic hemangioma and 10 cases of normal liver tissue.Expression was analyzed using the immunohistochemical streptavidin-peroxidase method and correlated with clinicopathological factors. Results Expression of FKBP12 was detected in 66.7% of HCC samples，a rate significantly higher than the 30.0% of adjacent tissues，20.0% of liver hemangioma and 40.0% of normal liver tissues（P<0.05）.The rate of FKBP52 expression was significantly higher in HCC tissues （63.3%） than in adjacent tissues （26.7%） and normal liver tissues （20.0%），but similar to the rate in liver hemangioma （40.0%）.Rates of FKBP12 and FKBP52 expression were similar in HCC tissues.There was no significant relationship between FKBP12 expression in HCC tissue and patient age，gender，cirrhosis， or hepatitis B virus infection，but expression was related to tumor size，pathology grade，and serum AFP level.There was no significant relationship between FKBP52 expression in HCC tissue and age，gender， tumor size，cirrhosis， or serum AFP level（P>0.05），but expression was related to pathology grade and hepatitis B virus infection（P<0.05）. Conclusion Expression of FKBP12 and FKBP52 correlate closely with incidence of HCC.FKBP12 may be involved in the proliferation and differentiation of tumor cells，and it may contribute to elevated serum AFP levels in liver cancer patients.FKBP52 may contribute to the differentiation of hepatocellular carcinoma and may participate in cellular processes in liver infected by hepatitis B virus.

Key words: Liver neoplasm, Hepatocellular carcinoma, FKBP12；FKBP52, Immunohistochemistry