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中国癌症防治杂志

中国癌症防治杂志 ›› 2014, Vol. 6 ›› Issue (3): 271-274.doi: 10.3969/j.issn.1674-5671.2014.03.11

• 临床研究 • 上一篇    下一篇

CT导向射频消融治疗肺部恶性肿瘤

  

  1. 江苏省肿瘤医院 胸外科，影像诊断科
  • 出版日期:2014-09-25 发布日期:2014-10-17
  • 通讯作者: 许林 E-mail:chenshilin@163.com
  • 基金资助:

    国家重点临床专科建设资助项目（2011-873）

To evaluate the efficiency of CT-guided radiofrequency ablation to treat pulmonary malignancies

  • Online:2014-09-25 Published:2014-10-17

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523

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被引次数

10

摘要： 目的 探讨CT导向下经皮肺穿刺射频消融治疗肺部肿瘤的有效性、安全性及并发症。方法 对不能手术的74例原发肺癌（其中鳞癌23例，腺癌48例，鳞腺癌2例，大细胞癌1例）和14例转移性肺癌共96个病灶（其中最大直径≤3 cm 31个，3~5 cm 56个，>5 cm 9个），在CT导向下行射频消融治疗，术后6个月随访评价疗效。结果 88例患者共行134次射频消融治疗，除1例术中癫痫发作中断手术而行二期射频消融治疗外，其余均顺利完成。术后6个月行CT复查，显示96个病灶体积中88个均进行性缩小，肿瘤内大片不规则低密度区，总有效率为91.7%。１年随访有效率为88.0%，1年无疾病进展生存率为95.5％。气胸发生率为7.9%。结论  CT导向下经皮肺穿刺射频消融治疗肺部肿瘤安全、有效，并发症较少，对不同肿瘤采取科学的射频消融治疗方案可取得较好的疗效。

关键词: 肺肿瘤, 射频消融, 肺转移癌, 体层摄影术, X线计算机

Abstract: Objective To evaluate the safety and therapeutic value of CT-guided radiofrequency ablation （RFA） in the treatment of pulmonary malignancies. Methods A total of 88 patients with lung malignancies， who altogether had 96 lesions， were treated using CT-guided RFA. The cohort included 14 cases of metastatic lung carcinoma and 74 cases of primary non-small cell lung cancer （NSCLC），which comprised various pathological types （23 cases of squamous cell carcinoma，48 adenocarcinoma，2 mixed carcinoma and 1 large cell carcinoma） and tumor sizes（≤3 cm，31 cases；3-5 cm，56 cases；>5 cm，9 cases）. Results Lesions in most patients became larger and showed fuzzy edges after RFA；some lesions showed bubble-like changes. Follow-up CT at 6 months showed that all 96 lesions had shrunk， with an overall efficacy of 91.6%. The 1-year local control rate was 88.0%， and the 1-year survival rate was 95.5%. Conclusion CT-guided percutaneous RFA is a safe，effective and minimally invasive therapy for treating pulmonary malignancies.

Key words: Lung neoplasm, Radiofrequency ablation, Metastatic carcinoma of lung, Tomography, X-ray computed