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中国癌症防治杂志

中国癌症防治杂志 ›› 2018, Vol. 10 ›› Issue (5): 365-370.doi: 10.3969/j.issn.1674-5671.2018.05.05

• 临床研究 • 上一篇    下一篇

中国人群HBV基因型及亚型与肝细胞癌相关性的Meta分析

  

  1. 广西医科大学附属肿瘤医院实验研究部；广西医科大学研究生院；广西医科大学公共卫生学院
  • 出版日期:2018-10-25 发布日期:2018-12-12
  • 通讯作者: 黄天壬 E-amil：tianrenhuang@sina.com
  • 基金资助:

    国家自然科学基金资助项目（81660561，81260319）；广西高校科学技术研究资助项目（ZD2014039）；广西研究生教育创新计划项目（YCSW2018109）

Meta-analysis：the relationship of hepatitis B virus genotypes，subgenotypes and hepato-cellular carcinoma in China

  • Online:2018-10-25 Published:2018-12-12

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摘要：

目的 探讨中国人群HBV基因型及亚型与肝细胞癌（以下简称“肝癌”）的相关性。方法 计算机检索文献，收集2007年1月至2017年2月公开发表的有关中国人群HBV基因型、亚型与肝癌相关性的病例对照研究，按纳入与排除标准筛选文献、评价质量并提取有效数据，采用RevMan 5.3进行Meta分析。结果 最终纳入中国人群HBV基因型与肝癌相关性研究37篇，其中病例组4 109例，对照组15 319例；HBV基因亚型（C1、C2、 B2）与肝癌相关性研究8篇，其中病例组931例，对照组5 793例；纳入文献质量评分均≥7分。Meta分析结果显示，携带HBV C基因型者罹患肝癌的风险较携带HBV B基因型高（OR=2.35，95%CI：1.93~2.87，P<0.001）；携带HBV C基因型与A/D基因型者罹患肝癌风险差异无统计学意义（OR=1.25，95%CI：0.20~7.82，P=0.81）；携带HBV C1亚型、HBV C2亚型者罹患肝癌的风险差异无统计学意义（OR=1.05，95%CI：0.66~1.68，P=0.82），携带HBV C2亚型者罹患肝癌风险较HBV B2亚型者高（OR=1.77，95%CI：1.38~2.27，P<0.001）。结论 中国人群携带HBV C基因型者罹患肝癌风险较其他主要基因型高，携带HBV C1亚型和HBV C2亚型者罹患肝癌风险相当，但HBV C2亚型者罹患肝癌风险均较携带HBV B2亚型者高。

关键词: 肝肿瘤, HBV, 基因型, 基因亚型, Meta分析, 中国

Abstract:

Objective  To explore the correlation between hepatitis B virus（HBV） genotype and subgenotype and hepatocellular carcinoma in China. Methods A case control study on the correlation between Chinese HBV genotypes，subgenotype and hepato-cellular carcinoma，published from January 2007 to February 2017，was retrieved in a comprehensive retrieval system. The literature was selected and the quality was evaluated and effective data were extracted according to the exclusion criteria. The Meta analysis was analyzed by RevMan 5.3 analysis. Results Finally，37 studies were included in the study of HBV genotype and hepatocellular carcinoma，4，109 cases in case group，15，319 in control group；8 in HBV gene subtype（C1，C2，B2） with hepatocellular carcinoma，931 in case group and 5，793 in control group，and the quality score of the included literature was more than 7. The results of Meta analysis showed that：⑴the risk of HBV C genotype was higher than that of genotype B（OR=2.35，95%CI：1.93-2.87，P＜0.001）；there was no significant difference in the risk of hepatocellular carcinoma of HBV C and A，D subgenotype（OR=1.25，95%CI：0.20-7.82，P=0.81）； ⑵there was no significant difference in the risk of hepatocellular carcinoma of HBV C1 and C2 subgenotype（OR=1.05，95%CI：0.66-1.68，P=0.82），and the risk of hepatocellular carcinoma in HBV C2 subgenotype is stronger than that of B2 subgenotype（OR=1.77，95%CI：1.38-2.27，P＜0.001）. Conclusions HBV genotype C has higher risk of liver cancer than other major genotypes. There is no significant difference in the risk of hepatocellular carcinoma in HBV C1 and C2 subgenotype，but the risk of hepatocellular carcinoma is higher in HBV C2 subgenotype than that in B2 subgenotype.

Key words:  Liver neoplasms, Hepatitis B virus, Genotype, Subgenotype, Meta-analysis, China