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中国癌症防治杂志

中国癌症防治杂志 ›› 2020, Vol. 12 ›› Issue (3): 335-340.doi: 10.3969/j.issn.1674-5671.2020.03.17

• 临床研究 • 上一篇    下一篇

体液免疫和细胞免疫在不同巴塞罗那分期肝细胞癌患者中的差异及临床意义

  

  1. 广西医科大学附属肿瘤医院；广西医科大学附属肿瘤医院疾病流程管理办公室；广西医科大学公共卫生学院；广西医科大学附属肿瘤医院实验研究部；广西医科大学附属肿瘤医院肝胆外科
  • 出版日期:2020-06-25 发布日期:2020-07-13
  • 通讯作者: 余红平 E-mail：yhp268@163.com
  • 基金资助:
    广西重点研发计划项目（AB18050020；AA18221001）；广西高校中青年教师科研基础能力提升项目（2019KY0120）

Difference in cellular and humoral immunity of hepatocellular carcinoma at different Barcelona stage and its clinical significance

  • Online:2020-06-25 Published:2020-07-13

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摘要： 目的 分析体液免疫和细胞免疫与肝细胞癌（hepatocellular carcinoma，HCC）患者巴塞罗那（Barcelona clinic liver cancer，BCLC）分期的相关性。方法 回顾性分析2014年1月至2017年12月在广西医科大学附属肿瘤医院入院治疗的1 164例HCC初治患者的体液免疫状况。采用免疫透射比浊法测定体液免疫因子的水平，采用流式细胞术检测患者细胞免疫因子的水平。结果 HCC患者体液免疫中IgG、IgA、C3、C4和C-反应蛋白（c-reaction protein，CRP）在不同BCLC分期中的水平差异有统计学意义（均P<0.05），其中C/D期患者中IgG、IgA、C3、C4和CRP水平均高于A期或B期。总T淋巴细胞在不同BCLC分期患者中的水平差异有统计学意义（P=0.040），其中C/D期患者中的总T淋巴细胞水平低于B期（P<0.05）。Spearman相关分析显示，IgG、IgA、C3、C4和CRP水平与BCLC分期均呈正相关（均P<0.05）。进一步分层分析发现IgG、IgA水平与BCLC分期的相关性受到性别因素的影响，而T淋巴细胞总数与BCLC的相关性受到性别和肝硬化背景的影响。结论 随着BCLC分期的增加，HCC患者的体液免疫功能增强，而细胞免疫功能受到抑制，尤其是男性和有肝硬化的患者。
【关键词】 肝细胞癌；细胞免疫；体液免疫；BCLC分期

关键词: 肝细胞癌, 细胞免疫, 体液免疫, BCLC分期

Abstract: Objective  To analyze the correlation between the cell immunity and humoral immunity and Barcelona clinic liver cancer （BCLC） stage of patients with hepatocellular carcinoma （HCC）. Methods A total of 1，164 cases of humoral immunity status of early treated HCC patients admitted to Guangxi Medical University Cancer Hospital from Jan 2014 to Dec 2017 were retrospectively analyzed. The level of humoral immunity factors was measured by immunoturbidimetry，the level of cellular immune factors was detected by the flow cytometry. Results The levels of IgG，IgA，C3，C4 or c-reaction protein（CRP） at different BCLC stage were significantly different（all P<0.05），and for HCC patients the levels of IgG，IgA，C3，C4 and CRP at stage C or D were all higher than those at stage A or B. The levels of total T cells at different BCLC stage were also significantly different（P=0.040），and the level of total T cells in HCC patients at stage C or D was lower than that at stage B（P<0.05）. Spearman correlation analysis showed that the levels of IgG，IgA，C3，C4 and CRP were positively correlated with BCLC stage（all P<0.05）. Further stratified analysis showed that the correlation between the level of IgG or IgA and BCLC stage was affected by gender，while the correlation between the level of total T cells and BCLC stage was affected by both gender and cirrhosis background. Conclusion With the increase of BCLC stage，the humoral immune function of HCC patients is enhanced，while cellular immune function is inhibited，especially for male and patients with cirrhosis.

Key words: Hepatocellular carcinoma, Cellular immune, Humoral immune, BCLC stage

中图分类号: 

  • R735.7