Abstract:

Objective To identify appropriate indications and efficacy of surgical treatment for patients with liver metastases from gastric cancer. Methods Medical records were retrospectively reviewed for 40 patients with liver metastases from gastric cancer who underwent gastrectomy with metastasectomy at our hospital between January 2010 and January 2012. Possible associations between clinicopathological factors and prognosis were analyzed using the log-rank test and Cox proportional hazards model. Results A total of 30 patients underwent R0 resection and 10 patients，R1 resection. No cases of death or severe complications such as massive hemorrhage were observed. Survival rates were 37.5% at 1 year，10% at 2 years，and 0 at 3 years. Median survival time was 10.5 months. Single-factor analysis identified the following predictors of poor prognosis: primary gastric serous violations，primary pathology type，perigastric lymph note metastasis， vascular tumor emboli，perineural invasion， diameter of metastasis，distribution of metastases，type of liver metastases，liver resection and radical extent. Multifactorial analysis identified the following predictors of poor prognosis：primary gastric serous violations，vascular tumor emboli，perineural invasion，diameter of metastasis and radical extent. Conclusion Indications for surgery in this type of patient may be the absence of primary serous violations，vascular tumor thrombi，and nerve invasion，the presence of liver metastases with a diameter <5 cm，and R0 resection.

Key words: Gastric neoplasm, Liver metastases, Surgical treatment, Prognosis