Abstract:

Objective To identify risk factors for acute lung injury induced by three-dimensional conformal radiotherapy （3DCRT） in patients with breast cancer after breast-conserving surgery. Methods A total of 86 breast cancer patients who received 3DCRT after breast-conserving surgery were retrospectively analyzed. Univariate and multivariate analyses were conducted to identify risk factors associated with acute radiation-induced lung injury. Results 9 patients （10.47%） experienced acute radiation-induced lung injury. Univariate analysis identified the following risk factors： radiation fields，ipsilateral lung V₅，V₁₀，V₁₅，V₂₀，V₂₅ and average amount of ipsilateral lung（P＜0.05）. Multivariate analysis identified ipsilateral lung V₂₀ as an independent risk factor for acute radiation-induced lung injury （P＜0.001）. Conclusion Ipsilateral lung V20 is an independent risk factor for acute lung injury induced by 3DCRT in patients with breast cancer after breast-conserving surgery.

Key words: Breast neoplasms , Radiation-induced lung injury, Three-dimensional conformal radiotherapy, Risk factors