Abstract:

Objective To analyze factors influencing imaging T residual in nasopharyngeal carcinoma （NPC） patients. Methods From June 2008 to June 2016，691 NPC patients were collected. The chi-squared test was used to compare residual rates among groups，and factors affecting imaging T residual were identified using logistic regression. Results Residual rate was significantly higher among patients older than 50 yr than among those younger，and it was significantly higher among men than women （P<0.05）. The rate also differed significantly among clinical stages and T stage. Rate differed significantly among patients with different tumor staging parameters （oropharyngeal，hypopharyngeal，nasal cavity，anterior vertebral muscle，carotid sheath area，medial pterygoid muscle，lateral pterygoid muscle，skull base，paranasal sinus，infratemporal fossa，intracranial，cavernous sinus，cranial nerve）. Rate was significantly higher among patients with metastatic tumors than among those with non-metastatic tumors （P<0.05）. Multifactorial analysis identified the following factors influencing nasopharyngeal imaging T （P<0.05）： gender，age，tumor staging parameters （oropharynx，skull base，cavernous sinus and cranial nerve）. Conclusion Risk factors of nasopharyngeal imaging T residual were male gender，older age and metastasis to oropharynx，base of the skull，cavernous sinus and cranial nerve.

Key words: Nasopharyngeal neoplasms, T residual, Intensity-modulated radiotherapy, Risk factors, Logistic regression