Abstract:

Objective To meta-analyze the literature on how well various imaging techniques（B ultrasound，CT，MRI，and PET/CT）can detect epithelial ovarian cancer recurrence after treatment. Methods We searched Medline，Embase，PubMed，Cochrane Library，EBMR，CBM，CJFD，CSJD，and Tsinghua Tongfang Database for relevant studies of diagnostic accuracy. Studies satisfying the inclusion criteria were selected and their quality assessed using the QUADAS tool. Data were meta-analyzed using Meta-Disc 1.4 software. Results Eight studies involving 478 patients with epithelial ovarian cancer analyzed by CT，four studies involving 231 patients analyzed by MRI and 15 studies involving 1，007 patients analyzed by PET/CT were included. Meta-analysis showed the following diagnostic performance using CT to detect epithelial ovarian cancer recurrence after treatment：diagnostic odds ratio，10.32（95%CI：4.93~21.62）; sensitivity，70%（95%CI：64%~75%）；specificity，81%（95%CI：75%~86%）；positive likelihood ratio，3.11（95%CI：2.30~4.19）；and negative likelihood ratio，0.35（95%CI：0.23~0.55）. The corresponding performance values for MRI were as follows：diagnostic odds ratio，55.90（95%CI：19.37~161.36）；sensitivity，87%（95%CI：82%~92%）；specificity，90%（95%CI：78%~97%）；positive likelihood ratio，7.57（95%CI：3.31~17.33）；and negative likelihood ratio，0.15（95%CI：0.06~0.39）. The corresponding performance values for PET/CT were as follows：diagnostic odds ratio，63.09（95%CI：26.29~151.43）；sensitivity，88% （95%CI：85%~91%）；specificity， 88% （95%CI：84%~94%）；positive likelihood ratio，7.64 （95%CI：2.56~22.86）；and negative likelihood ratio，0.13（95%CI：0.08~0.22）. Conclusion CT，MRI，and PET/CT show good sensitivity and specificity for diagnosing epithelial ovarian cancer recurrence after treatment，with PET/CT showing greater sensitivity and specificity than MRI and CT.

Key words: Ovarian neoplasm, B ultrasound, CT, MRI, PET/CT, Recurrence, Meta-analysis