Objective To explore the effects of multidisciplinary collaboration-based clinical pathway management on quality of life of patients with laryngectomy. Methods A total of 51 patients with laryngectomy were randomly divided into the experimental group（n=26） and the control group（n=25）. A clinical pathway based on multidisciplinary collaboration was established following a literature review and preliminary experimental treatment. Patients in the experimental group were given clinical pathway management，while patients in the control group were given routine nursing care during hospitalization. UW-QOL was used to evaluate the quality of life of all patients at 6 months after laryngectomy. Results UW-QOL scores were significantly higher in the experimental group than in the control group（P<0.001）.Conclusions Clinical pathway management based on multidisciplinary collaboration can effectively improve the quality of life of patients with laryngectomy.