Abstract:

Objective To explore the expression of Pygopus2 （PYGO2） and its clinical significance in breast cancer. Methods PYGO2 data were retrieved from the Oncomine database and the relationship between PYGO2 and prognosis of breast cancer patients was retrieved from an online survival analysis tool “Kaplan-Meier Plotter” database. Results A total of 45 studies （including 3，730 samples） were involved PYGO2 in breast cancer tissues and normal tissues. PYGO2 expression levels in breast cancer was higher than that in normal tissues（P<0.05）. Kaplan-Meier Plotter of survival analysis indicated that high expression of PYGO2 was closely associated with better survival in breast cancer，including overall survival （HR=0.69，95%CI: 0.51-0.95，P=0.021），relapse-free survival （HR=0.60，95%CI: 0.51-0.70，P<0.001） and distant metastasis-free survival （HR=0.61，95%CI: 0.43-0.87，P=0.005）. Conclusion PYGO2 is highly expressed in breast cancer tissues and associated with poor prognosis in breast cancer patients，which may be a potential biomarker for estimating the prognosis of breast cancer.

Key words: Breast , cancer, Pygopus2, Oncomine, Kaplan-Meier Plotter