Abstract: Objective To explore the clinical application effect of ultrasound-guided transverse abdominal planar block combined with general anesthesia in the laparoscopic radical resection of colorectal cancer. Methods From June 2017 to June 2019，100 patients undergoing laparoscopic radical resection of colorectal cancer in Deyang People's Hospital were selected，and divided into control group（n=50） and observation group（n=50） according to the random number table. The control group was given general anesthesia，and on this basis，the observation group was given ultrasound-guided horizontal abdominal block. The hemodynamics，analgesic effect and adverse reactions were compared between the two groups. Results The mean arterial pressure（MAP） and heart rate（HR） at the time of skin incision，resection of cancer focus and the end of operation，dosage of propofol and sufentanil and the time of opening eyes，extubating trachea and fully awakening，the VAS scores at 2，12，24，48 and 72 hours after operation in observation group were significantly lower than those in control group（P<0.05）. The times of analgesia pump and remedial analgesia in observation group were significantly lower than those in control group（P<0.05），but the satisfactory rate of analgesia in observation group was significantly higher than that in control group（96.0% vs 82.0%，χ²=5.005，P=0.025）. There was no significant difference in the incidence of adverse reactions between control group and observation group（10.0% vs 14.0%，χ²=0.379，P=0.538）. Conclusions  Ultrasound-guided transverse abdominal planar block combined with general anesthesia can effectively improve the anesthesia effect of patients undergoing laparoscopic radical resection of colorectal cancer，stabilize hemodynamics，reduce dosage of general anesthesia，and has better sefety，which is worthy of clinical promotion and application.

Key words: Colorectal cancer；Ultrasound-guided；Transverse abdominal planar block；Laparoscopic radical resection of colorectal cancer；Hemodynamics；Pain">Colorectal cancer；Ultrasound-guided；Transverse abdominal planar block；Laparoscopic radical resection of colorectal cancer；Hemodynamics；Pain ')">">