Abstract:  Objective To investigate the expression of priline-rich 11（PRR11） and spindle and kinetochore associated complex subunit 2（SKA2） in cervical cancer tissues and its relationship with prognosis. Methods The cervical cancer tissues and adjacent normal tissues of 289 patients with cervical cancer treated in Yantai Yuhuangding Hospital affiliated to Qingdao University from January 2012 to December 2015，were collected. The expression of PRR11 and SKA2 proteins in cervical cancer tissues was detected by immunohistochemiscal staining，and their relationship with the clinicopathological characteristics of patients was analyzed. The Spearman method was used to analyze the correlation between PRR11 and SKA2 expression，Kaplan-Meier was used to analyze the overall survival rate，and Cox proportional risk regression model was used to analyze the prognostic factors. Results The positive expression rate of PRR11 and SKA2 in cervical cancer tissues were higher than those in adjacent normal tissues（60.21% vs 16.96%，χ²=114.081，P＜0.001；69.55% vs 37.37%，χ²=60.143，P＜0.001）. The Spearman correlation analysis results showed that PRR11 was positively correlated with SKA2 protein expression（r=0.725， P<0.001）. Both PRR11 and SKA2 protein expression were related to FIGO stage，tissue differentiation degree and lymph node metastasis（P<0.05）. The 3-year OS of patients with PRR11 and SKA2 positive expression were significantly lower than those of patients with negative expression（78.16% vs 94.78%，P=0.002；82.09% vs 90.91%，P=0.036）. FIGO stage Ⅲ-Ⅳ，PRR11 positive expression and SKA2 positive expression were the independent risk factors affecting the prognosis of cervical cancer patients（HR=1.698，95%CI：1.369-2.876，P＜0.001；HR=2.392，95%CI：1.294-3.596，P＜0.001；HR=1.597，95%CI：1.024-2.302，P＜0.001）. Conclusion PRR11 and SKA2 are highly expressed and positively correlated in cervical cancer tissues. They are independent risk factors affecting the prognosis of patients and may become effective indicators for the diagnosis and prognosis assessment of cervical cancer.

Key words: Cervical cancer, PRR11, SKA2, Prognosis