Abstract: Objective To analyze the high-risk assessment and screening results of the urban cancer early diagnosis and treatment in Quzhou city, Zhejiang province from 2014 to 2018. Methods The permanent residents with aged 40-74 and full behavioral capacity in Quzhou city, Zhejiang province, were sampled as the research object, based on the cluster sampling method. The high-risk group was identified, through preliminary screening questionnaire, and clinically screened to calculate the cancer high-risk rate, clinical screening participation rate and positive lesion detection rate of the population. Results From 2014 to 2018, the high-risk assessment was completed for a total of 50, 114 people, and 25, 375 people were assessed as being at high risk of cancer, with an overall high risk rate of 50.63%. The high risk rate of males (57.28%) was higher than that of females (45.36%). The highest risk rate was found in the 60-64 age group. The high-risk rates of various cancers from high to low were upper gastrointestinal cancer (26.24%), lung cancer (23.55%), liver cancer (17.22%), female breast cancer (14.91%) and colorectal cancer (12.67%). The clinical screening participation rates from high to low were women's breast cancer (55.19%), liver cancer (47.47%), lung cancer (46.31%), upper gastrointestinal cancer (28.26%) and colorectal cancer (18.24%). Except for colorectal cancer, the participation rate of male was lower than female for other types of cancer. The positive rates of all cancer types from high to low were female breast cancer (20.54%), lung cancer (18.04%), liver cancer (3.22%), colorectal cancer (1.73%) and upper gastrointestinal cancer (0.16%). The detection rates of male liver cancer, upper gastrointestinal cancer and colorectal cancer positive lesions were higher than that of female, while the detection rate of lung cancer positive lesions was lower than that of female. Conclusions People actively participate in the urban cancer early diagnosis and treatment in Quzhou city, Zhejiang province, from 2014 to 2018. The clinical screening participation rate is high, though the clinical screening participation rate and the positive lesion detection rate of colorectal cancer and upper gastrointestinal cancer are relatively low in the invasive screening program. Proper screening strategy should be explored in the future; the propaganda and education for high-risk population should be strengthened, especially for male and people aged 60 to 64, to improve the effect of cancer screening.

Key words: Cancer, Organizational screening, Early diagnosis and treatment, Effect evaluation, High-risk population