Table of Content

25 December 2021, Volume 13 Issue 6 Previous Issue    Next Issue

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Digital health promotes precise health management of tumors DING Kexin, CHEN Dafang 2021, 13 (6):  569-574.  doi: 10.3969/j.issn.1674-5671.2021.06.01 Abstract ( 274 )   PDF (507KB) ( 811 )   Save Related Articles | Metrics

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A discussion of the influencing factors of the efficacy of tumor immune checkpoint inhibitors： from the micro to the macro DU Cheng, JIN Shanxiu, XIE Xiaodong 2021, 13 (6):  575-584.  doi: 10.3969/j.issn.1674-5671.2021.06.02 Abstract ( 617 )   PDF (656KB) ( 415 )   Save Related Articles | Metrics

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Predictors of immunotherapy efficacy from the perspective of tumor immune microenvironment BAI Rilan, CUI Jiuwei 2021, 13 (6):  585-593.  doi: 10.3969/j.issn.1674-5671.2021.06.03 Abstract ( 698 )   PDF (504KB) ( 588 )   Save Related Articles | Metrics

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Challenges and solutions of CAR-T cell therapy ZHU Jinghan, LIANG Yuanzheng, WANG Liang 2021, 13 (6):  594-601.  doi: 10.3969/j.issn.1674-5671.2021.06.04 Abstract ( 738 )   PDF (496KB) ( 943 )   Save Related Articles | Metrics

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Current status and research progress of diagnosis and treatment of tumor immune-related hypophysitis ZHENG Fang, XIE Xiaodong 2021, 13 (6):  602-606.  doi: 10.3969/j.issn.1674-5671.2021.06.05 Abstract ( 541 )   PDF (410KB) ( 207 )   Save Related Articles | Metrics

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Radiation-induced senescence and autophagy in polyploid breast cancer cells MENG Fanjie, YAN Ying, XIONG Chan, WANG Lili, ZHAO Song, XING Sining, YU Huiying 2021, 13 (6):  607-612.  doi: 10.3969/j.issn.1674-5671.2021.06.06 Abstract ( 290 )   PDF (1221KB) ( 191 )   Save Objective To investigate the role of senescence and autophagy in radiation-induced polyploidy breast cancer cells. Method Breast cancer MDA-MB-231 cells were irradiated with a dose of 7 Gy in 6 MV X-ray mode, and the cell morphology changes were observed on the 3rd (Day 3 group), 5th (Day 5 group), 7th (Day 7 group), 11th (Day 11 group) and 19th (Day 19 group) days, respectively. The cell ploidy was detected by flow cytometry, cell senescence was detected by β-galactosidase, and the expression of senescence and autophagy related proteins was detected by Western blot. The GEPIA tool was used to analyze the difference of PLK1 expression between breast tissues and breast cancer tissues. Results After 7 Gy dose irradiation, the volume of MDA-MB-231 cells in Day 3 group, Day 5 group and Day 7 group became larger, and the proportion of polyploid cell subsets (DNA content>4 N) was significantly higher than that of the control group MDA-MB-231 cells without radiation treatment (all P<0.0001), and cell senescence occurred at the same time. Compared with the control group MDA-MB-231 cells without radiation treatment, the expression of DNA damage repair protein PARP and DNA synthesis related proteins Rb, E2F-1, E2F-2 were down-regulated in Day 3 and Day 5 groups. The ratio of phage-related protein LC3B/LC3A was significantly increased. The expression of nuclear membrane integrity-related protein Lamin B1 and DNA damage repair protein PARP were down-regulated, and the expression of DNA damage response-related protein PLK1 was up-regulated, the differences were statistically significant (all P<0.05). Compared with breast tissues，PLK1 was highly expressed in breast cancer tissues (P<0.05). Conclusions Radiation-induced senescence of breast cancer cells can be a favorable condition for the formation of polyploid cell. Senescence and autophagy may contribute to self-repair and deploid proliferation of polyploid cells. Related Articles | Metrics

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Regulation and mechanism of IL-33 on apoptosis and cell cycle of acute myeloid leukemia cell lines HL-60 and NB4 CHEN Xuexin, WANG Yiqian 2021, 13 (6):  613-617.  doi: 10.3969/j.issn.1674-5671.2021.06.07 Abstract ( 268 )   PDF (525KB) ( 163 )   Save Objective To investigate the regulation and mechanism of interleukin-33（IL-33） on the apoptosis and cell cycle of acute myeloid leukemia (AML) cells HL-60 and NB4. Methods AML cell lines HL-60 and NB4 were treated with IL-33 and p38 mitogen-activated protein kinase（p38 MAPK） inhibitor (SB203580) for 72 h. The cell apoptosis rate was detected by Annexin V/DAPI double staining flow cytometry and the cell cycle was detected by cell cycle detection kit. The expression levels of CDK1 protein and p38 MAPK phosphorylation were detected by Western blot. Results Compared with the control group, the apoptosis level of HL-60 and NB4 cells in IL-33 group was reduced after IL-33 treatment (P<0.05), the proportion of S phase in cell cycle increased (P<0.001); while the apoptosis level of SB+IL-33 group was higher than that of IL-33 group after combined treatment with SB203580 and IL-33 (P<0.05), and the percentage of S phase cells was lower than that of IL-33 group (P<0.05). Western blot results showed that the phosphorylation level of p38 MAPK (p-p38 MAPK) and the expression level of CDK1 protein were significantly increased in IL-33 group, compared with the control group (all P<0.05). The expression levels of p-p38 MAPK and CDK1 in SB+IL-33 group were significantly lower than those in IL-33 group (all P<0.05). Conclusions IL-33 can inhibit apoptosis and cell cycle of AML cell lines HL-60 and NB4 by activating p38 MAPK. Related Articles | Metrics

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Analysis of screening results of urban cancer early diagnosis and treatment program in Quzhou city,Zhejiang province ,2014—2018 LEI Ruijiao, ZHANG Meizhen, WANG Le, FANG Zhimei, WANG Youqing, LI Huizhang, ZHU Chen, DU Lingbin 2021, 13 (6):  618-623.  doi: 10.3969/j.issn.1674-5671.2021.06.08 Abstract ( 200 )   PDF (389KB) ( 232 )   Save Objective To analyze the high-risk assessment and screening results of the urban cancer early diagnosis and treatment in Quzhou city, Zhejiang province from 2014 to 2018. Methods The permanent residents with aged 40-74 and full behavioral capacity in Quzhou city, Zhejiang province, were sampled as the research object, based on the cluster sampling method. The high-risk group was identified, through preliminary screening questionnaire, and clinically screened to calculate the cancer high-risk rate, clinical screening participation rate and positive lesion detection rate of the population. Results From 2014 to 2018, the high-risk assessment was completed for a total of 50, 114 people, and 25, 375 people were assessed as being at high risk of cancer, with an overall high risk rate of 50.63%. The high risk rate of males (57.28%) was higher than that of females (45.36%). The highest risk rate was found in the 60-64 age group. The high-risk rates of various cancers from high to low were upper gastrointestinal cancer (26.24%), lung cancer (23.55%), liver cancer (17.22%), female breast cancer (14.91%) and colorectal cancer (12.67%). The clinical screening participation rates from high to low were women's breast cancer (55.19%), liver cancer (47.47%), lung cancer (46.31%), upper gastrointestinal cancer (28.26%) and colorectal cancer (18.24%). Except for colorectal cancer, the participation rate of male was lower than female for other types of cancer. The positive rates of all cancer types from high to low were female breast cancer (20.54%), lung cancer (18.04%), liver cancer (3.22%), colorectal cancer (1.73%) and upper gastrointestinal cancer (0.16%). The detection rates of male liver cancer, upper gastrointestinal cancer and colorectal cancer positive lesions were higher than that of female, while the detection rate of lung cancer positive lesions was lower than that of female. Conclusions People actively participate in the urban cancer early diagnosis and treatment in Quzhou city, Zhejiang province, from 2014 to 2018. The clinical screening participation rate is high, though the clinical screening participation rate and the positive lesion detection rate of colorectal cancer and upper gastrointestinal cancer are relatively low in the invasive screening program. Proper screening strategy should be explored in the future; the propaganda and education for high-risk population should be strengthened, especially for male and people aged 60 to 64, to improve the effect of cancer screening. Related Articles | Metrics

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Analysis of temporal trend of cancer incidence in Rugao city,Jiangsu province,2013—2017 SHA Liuqiang, LYU Jiaai, WANG Shulan, WU Qiong, XU Peipei, CAI Meiling 2021, 13 (6):  624-628.  doi: 10.3969/j.issn.1674-5671.2021.06.09 Abstract ( 237 )   PDF (353KB) ( 179 )   Save  Objective To analyze the temporal trend of malignant tumor incidence in Rugao city, Jiangsu province from 2013 to 2017, and to provide a scientific basis for cancer prevention and treatment. Methods The incidence time data of malignant tumors in Rugao city from 2013 to 2017 were collected. The crude incidence, Chinese standard population rate(ASR China), world standard rate (ASR, world) and annual change percentage (APC) of malignant tumors were calculated for different genders, different age groups and different categories. Results From 2013 to 2017, no significantly increasing or decreasing trend was observed in crude incidence, ASR China and ASR world of malignant tumors in Rugao (APC=0.63%, -1.75%, -1.87%, all P>0.05), and all the indices of male malignant tumors were significantly higher than those of female. The crude incidence of malignant tumor in the whole population and male residents of Rugao city showed an significantly decreasing trend (APC=-4.01%, -7.86%, all P<0.05) in age 15-44 group, but there was no significantly decreasing trend in other age groups. The crude incidence of female residents in all age groups showed no obvious trend. In the past 5 years, esophageal cancer ranked first in the incidence of malignant tumors in Rugao, followed by lung cancer, liver cancer, gastric cancer and colorectal cancer. Among the top 10 malignant tumors, the crude incidence of lung cancer showed a significantly increasing trend (APC=5.71%, P<0.05), and the ASR China of esophageal cancer and gastric cancer showed a decreasing trend (APC=-6.66%, -5.27%, all P<0.05). The crude incidence of lung cancer of male showed a significantly increasing trend (APC=7.48%, P<0.05), while the male ASR China of gastric cancer and the crude incidence of brain and central nervous system tumors showed a decreasing trend (APC=-6.80%, -1.88%, all P<0.05), No obvious trend was observed in the incidence of the top 10 malignancies of female. Conclusions From 2013 to 2017, the incidence of malignant tumors in Rugao city, Jiangsu province is relatively stable, but lung cancer show a rapidly increasing trend. In the future, more attention should be paid to lung cancer, and target-based prevention and control measures should be taken. Related Articles | Metrics

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Analysis of cancer mortality trend of urban residents in Shenyang,2013—2017 LYU Yi, ZHANG Xinyu, NIE Huifang, LI Xun 2021, 13 (6):  629-634.  doi: 10.3969/j.issn.1674-5671.2021.06.10 Abstract ( 201 )   PDF (485KB) ( 126 )   Save Objective To analyze the cancer mortality and its changing trend for the urban residents in Shenyang from 2013 to 2017.  Methods The death data of malignant tumors were extracted from the follow-up registration of tumors in Shenyang, to calculate the crude mortality, standardized rate (Chinese standard population, ASR China), age-specific mortality, cumulative mortality (0-74 years old), and truncated mortality (35-64 years old). The χ2 test was performed on the mortalities of male, female and all age groups by SPSS 23.0 software; The death trend was analyzed by the Joinpoint 3.5.3 software. Results From 2013 to 2017, the crude mortality rate of malignant tumors for the urban residents in Shenyang was 222.16/105, the ASR China was 100.50/105, and the cumulative rate (0-74 years old) was 10.88%. The standardized mortality of malignant tumors and male standardized mortality of malignant tumors during the 5 years showed a downward trend (APC=-1.77%, P=0.030; APC=-1.78%, P=0.020) , and the crude mortality rate of malignant tumor was higher in males than in females (χ2=1, 512.28, P<0.001); The top five mortality rates of malignant tumors were lung cancer, liver cancer, colorectal cancer, gastric cancer and esophageal cancer in male, while the top five mortality rates of female malignant tumors were lung cancer, colorectal cancer, breast cancer, liver cancer and gastric cancer. Conclusions From 2013 to 2017, the mortality rate of malignant tumor for the urban residents in Shenyang decrease. The major types of cancer for prevention and control include lung cancer, breast cancer, liver cancer, colorectal cancer, gastric cancer and esophageal cancer. Related Articles | Metrics

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Expression of netrin-G1 in serum and tissues of patients with hepatocellular carcinoma and its clinical significance GAO Xing, YE Jiazhou, PIAO Xuemin, LI Yongqiang, LIN Yan, LIANG Rong 2021, 13 (6):  634-640.  doi: 10.3969/j.issn.1674-5671.2021.06.11 Abstract ( 264 )   PDF (631KB) ( 146 )   Save  Objective To investigate the expression of netrin-G1 (NTNG1) in serum samples and tissues of hepatocellular carcinoma (HCC) patients and its clinical significance. Methods A total of 63 cases of HCC tissue samples confirmed by pathology in Guangxi Medical University Cancer Hospital were collected. The expression of NTNG1 protein was detected by Western blot, and the relationship between the expression level and clinicopathological features as well as prognosis was analyzed. The peripheral serum samples of 90 patients with HCC, hepatitis, healthy subjects, and other tumor patients admitted to the hospital during the same period were collected, and the serum NTNG1 levels was detected by ELISA. Results NTNG1 was highly expressed in HCC tissues (P=0.001), which was an independent risk factor affecting the overall survival of HCC patients. The serum level of NTNG1 in HCC group was significantly higher than that in other control groups (all P<0.001). The receiver operating characteristic (ROC) curve showed that the sensitivity and specificity of HCC were 84.62% and 76.56%, respectively, and the area under the ROC curve was 0.8251. Conclusions NTNG1 is highly expressed in HCC tissues and associated with poor prognosis of HCC patients, which may be a potential prognostic evaluation marker for HCC patients． Related Articles | Metrics

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Clinical efficacy of stereotactic body radiation therapy on liver metastases WANG Zimeng, XIANG Zuolin 2021, 13 (6):  641-646.  doi: 10.3969/j.issn.1674-5671.2021.06.12 Abstract ( 240 )   PDF (691KB) ( 152 )   Save Objective To investigate the clinical efficacy of stereotactic body radiation therapy (SBRT) on liver metastases.  Methods The clinical data of 43 patients with liver metastases admitted to Shanghai East Hospital of Tong Ji University from December 2016 to May 2020 were retrospectively analyzed. All the patients underwent 4D-CT or respiration gating for CT simulation; a total of 58 lesions received SBRT, with a radiation dose of 36-70 Gy; the number of splits was 5-10 times, once a day and 5 times a week. Results A total of 43 patients successfully completed the whole course of radiationtherapy. The median follow-up time was 15.6 months (range: 2.0-31.9 months). The 2-year overall survival rate, local control rate and progression-free survival rate were 55.4％, 86.0％ and 5.9％, respectively. The common grade Ⅰ-Ⅱadverse reactions were anorexia (6 cases), fatigue (6 cases), myelosuppression (3 cases) and-liver pain (1 case), respectively, and no grade Ⅲor above was found. The average score of the EQ-5D-5L quality of life questionnaire was 0.848 (with a standard deviation of 0.277). Conclusions SBRT on liver metastases can obtain better local control rate and fewer adverse reactions. Its long-term efficacy and safety deserve further exploration in randomized controlled trials. Related Articles | Metrics

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Correlation of miR-7 and SP-1 with radiotherapy sensitivity in NSCLC patients TANG Chao, LI Jianmin, PAN Chanyuan, TAN Wenwen, LIU Hui 2021, 13 (6):  647-652.  doi: 10.3969/j.issn.1674-5671.2021.06.13 Abstract ( 208 )   PDF (525KB) ( 110 )   Save Objective To investigate the correlation of miR-7 and its downstream target specific protein 1(SP-1) with the radiosensitivity in non-small cell lung cancer (NSCLC) patients. Methods The tumor tissues, adjacent tissues and peripheral blood of 116 patients with primary NSCLC, admitted to the First Affiliated Hospital of Hunan Normal University from July 2018 to September 2020, were collected. The expression of miR-7 in tissue samples and peripheral blood serum were measured by real-time fluorescent quantitative PCR. The expression of SP-1 protein was detected by immunohistochemistry. The factors affecting the radiosensitivity of NSCLC patients were analyzed by the logistic regression model. Results The expression of miR-7 in tumor tissues of NSCLC patients was lower than that in adjacent tissues (P<0.001), while the positive expression rate of SP-1 protein was higher than that in adjacent tumor tissues (P<0.001). Pearson showed that serum miR-7 was positively correlated with the expression of miR-7 in tumor tissue (r=0.492, P<0.001), and serum miR-7 expression in NSCLC patients with positive SP-1 expression was lower than that in patients with negative SP-1 expression (P=0.005). The expression levels of miR-7 in serum and tissue of patients with T3-4 stage, TNM stageⅢA-B, smoking and radiation-induced lung injury were decreased (all P<0.05), and the positive rate of SP-1 was increased in cancer tissues (all P<0.05). Compared with the radiation sensitivity group, the relative expression of miR-7 in serum and tumor tissue of the radiation resistance group was decreased (all P<0.001), and the positive expression rate of SP-1 was increased (P<0.001). The receiver operating characteristic curve showed that the area under the curve of serum miR-7 to predict rodiotherapy resistance in NSCLC patients was 0.822 (95%CI: 0.746-0.897). Decreased serum miR-7 expression was a risk factor for radiotherapy sensitivity (P=0.009). Conclusions Serum miR-7 has a good efficacy in predicting radiotherapy resistance. miR-7 and its downstream targeted molecular SP-1 are potential radio sensitizing targets. Related Articles | Metrics

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Predictive value of 18F-FDG PET/CT metabolic parameters for the efficacy of chemoradiotherapy for stage ⅡB cervical cancer SUN Fangli, LU Qiuping, WU Nengxian, MO Linmei, SONG Hongli 2021, 13 (6):  653-657.  doi: 10.3969/j.issn.1674-5671.2021.06.14 Abstract ( 197 )   PDF (410KB) ( 135 )   Save Objective To investigate the predictive value of 18F-FDG PET/CT metabolic parameters for the efficacy of chemoradiotherapy for stage ⅡB cervical cancer. Methods A total of 29 patients with stage ⅡB cervical cancer who underwent concurrent chemoradiotherapy were retrospectively analyzed on a cohort basis. Before treatment, 18F-FDG PET/CT whole body imaging examination was performed, and metabolic parameters, including maximum standardized uptake values (SUVmax), average standardized uptake values (SUVavg), minimum standardized uptake values (SUVmin), peak standardized uptake values (SUVpeak), tumor metabolic volume (MTV), and total lesion glycolysis (TLG) of the lesion, were obtained. According to the efficacy evaluation criteria, the patients were divided into the radio-chemotherapy sensitive group and the radio-chemotherapy resistant group. The relationship between 18F-FDG PET/CT metabolic parameters and the efficacy of chemoradiotherapy for stage ⅡB cervical cancer was compared. The value in predicting the efficacy of chemoradiotherapy was evaluated by receiver operating characteristic (ROC) curve. Results The SUVmax, SUVavg, SUVpeak and SUVmin values of the radiochemotherapy sensitive group were insignificantly different from those of the radiochemotherapy resistance group (all P>0.05), while there were statistically significant differences in TLG and MTV values between two groups (P=0.025, 0.009). The area under the ROC curve of TLG and MTV were 0.753 and 0.793, respectively. The sensitivity, specificity, and accuracy of MTV in predicting the efficacy of chemoradiotherapy were 77.8%, 81.8%, and 79.3%, respectively; TLG were 66.7%, 81.8%, and 75.3%, respectively.  Conclusions 18F-FDG PET/CT metabolic parameters have a good predictive value for the efficacy of chemoradiotherapy for stage ⅡB cervical cancer. Related Articles | Metrics

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Follow-up analysis of 15 malignant tumors in a cancer hospital in Guangxi,2011—2020 CHEN Lijun, LIANG Xiumei, WU Yun, LU Xiangning, LU Yanyu 2021, 13 (6):  658-662.  doi: 10.3969/j.issn.1674-5671.2021.06.15 Abstract ( 203 )   PDF (359KB) ( 138 )   Save Objective To analyze the follow-up data of malignant tumor cases of a cancer hospital in Guangxi from 2011 to 2020 and to determine the follow-up status, providing reference for further improving the follow-up of cancer patients. Methods The follow-up data of 15 types of malignant tumors registered in the hospital from 2011 to 2020 were collected. The follow-up information was statistically analyzed by Excel 2013, to calculate the follow-up response rate, lost follow-up rate and effective follow-up rate . Results A total of 62, 527 patients with 15 types of malignant tumors were registered from 2011 to 2020, and 61, 333 patients were followed up. The average follow-up response rate was 95.25%, the average lost follow-up rate was 28.21%, and the average effective follow-up rate was 67.04%; among them, the effective follow-up rate of breast cancer patients was the highest, with an average of 89.97%. The average effective follow-up rate of 15 types of malignant tumors increased year by year from 2011 to 2020, and the average effective follow-up rate of each cancer from 2016 to 2020 was significantly higher than that from 2011 to 2015 (85.44% vs 48.64%). From 2011 to 2020, telephone follow-up and outpatient follow-up for 15 types of malignant tumors accounted for 36.35% and 63.65%, respectively, of the total follow-up. Among them, outpatient follow-up of prostate cancer, breast cancer, uterine body cancer, ovarian cancer and cervical cancer  accounted for 78.69%, 78.61%, 68.19%, 65.57% and 62.20%, respectively. Conclusions In recent 10 years, the effective follow-up rate of malignant tumors in this hospital has been continuously increasing, but the quality of follow-up still needs to be further improved. Establishing effective clinical follow-up mode is the key to improve the quality of follow-up and reduce the lost follow-up rate. Related Articles | Metrics

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Analysis of the opportunistic screening results of upper gastrointestinal cancer in Guangxi,2019 CAI Xinlian, HUANG Yueli, ZHONG Yi, LIU Aiqun 2021, 13 (6):  662-666.  doi: 10.3969/j.issn.1674-5671.2021.06.16 Abstract ( 239 )   PDF (421KB) ( 242 )   Save Objective To analyze the opportunistic screening data of upper gastrointestinal cancer in Guangxi in 2019 to provide guidance for the opportunistic screening of upper gastrointestinal tract. Methods The clinical medical records collected from the Guangxi upper gastrointestinal cancer management system in 2019 (July 1, 2019-June 30, 2020) for Guangxi upper gastrointestinal cancer opportunistic screening were retrospective analysis. The the biopsy rate, the detection rate of esophageal/gastric neoplastic lesions and the early diagnosis rate of esophageal cancer/gastric cancer were calculated and compared among different gender groups and age groups. Results A total of 10, 357 patients were included in the opportunistic screening of upper gastrointestinal cancer. Among them, 5, 897 patients underwent biopsy histopathological examination. The biopsy rates of esophagus, cardia and stomach were 14.96% (882 cases), 3.02% (178 cases), 91.44% (5, 392 cases), respectively. A total of 126 cases of esophageal neoplastic lesions (1.22%), 37 cases of early cancer (29.37%); 210 cases of gastric neoplastic lesions (2.03%), 66 cases of early cancer (31.43%); and 19 cases of cardia neoplastic lesions (0.18%), 4 cases of early cancer (21.05%); 229 cases (2.21%) of gastric and cardia neoplastic lesions, 70 cases (30.57%) of gastric and cardia early cancers were detected. There were statistically significant differences in the detection rate of neoplastic lesions in gender and age groups (all P<0.001). There was no significant difference in the early diagnosis rate of esophageal cancer and gastric cancer in gender and age groups (all P>0.05). Before the age of 80, the detection rate of neoplastic lesions in the esophagus and stomach (including the cardia) increased with age (χ2=46.716, P<0.001; χ2=51.989, P<0.001). Conclusions The detection rate of opportunistic screening and the rate of early diagnosis for upper gastrointestinal cancer in Guangxi in 2019 are not high. It is necessary to further improve the awareness of cancer prevention for the public, especially the male over 40 years old. Related Articles | Metrics

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Ceruloplasmin and malignant tumors QIN Qian, MI Jiaqing, FENG Qinmei 2021, 13 (6):  667-671.  doi: 10.3969/j.issn.1674-5671.2021.06.17 Abstract ( 398 )   PDF (346KB) ( 276 )   Save Related Articles | Metrics

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Research progress on the classification of diffuse large B-cell lymphoma LI Zhe, CEN Hong 2021, 13 (6):  672-676.  doi: 10.3969/j.issn.1674-5671.2021.06.18 Abstract ( 257 )   PDF (318KB) ( 677 )   Save Related Articles | Metrics

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Research development of postoperative adjuvant therapy for upper tract urothelial carcinoma WEN Rao, WU Yikun, YANG Chao, CHEN Wei, GONG Maodi, SONG Shang, PEI Jun, XU Shuxiong 2021, 13 (6):  677-682.  doi: 10.3969/j.issn.1674-5671.2021.06.19 Abstract ( 227 )   PDF (347KB) ( 227 )   Save Related Articles | Metrics