Abstract: Objective To analyze the opportunistic screening data of upper gastrointestinal cancer in Guangxi in 2019 to provide guidance for the opportunistic screening of upper gastrointestinal tract. Methods The clinical medical records collected from the Guangxi upper gastrointestinal cancer management system in 2019 (July 1, 2019-June 30, 2020) for Guangxi upper gastrointestinal cancer opportunistic screening were retrospective analysis. The the biopsy rate, the detection rate of esophageal/gastric neoplastic lesions and the early diagnosis rate of esophageal cancer/gastric cancer were calculated and compared among different gender groups and age groups. Results A total of 10, 357 patients were included in the opportunistic screening of upper gastrointestinal cancer. Among them, 5, 897 patients underwent biopsy histopathological examination. The biopsy rates of esophagus, cardia and stomach were 14.96% (882 cases), 3.02% (178 cases), 91.44% (5, 392 cases), respectively. A total of 126 cases of esophageal neoplastic lesions (1.22%), 37 cases of early cancer (29.37%); 210 cases of gastric neoplastic lesions (2.03%), 66 cases of early cancer (31.43%); and 19 cases of cardia neoplastic lesions (0.18%), 4 cases of early cancer (21.05%); 229 cases (2.21%) of gastric and cardia neoplastic lesions, 70 cases (30.57%) of gastric and cardia early cancers were detected. There were statistically significant differences in the detection rate of neoplastic lesions in gender and age groups (all P<0.001). There was no significant difference in the early diagnosis rate of esophageal cancer and gastric cancer in gender and age groups (all P>0.05). Before the age of 80, the detection rate of neoplastic lesions in the esophagus and stomach (including the cardia) increased with age (χ²=46.716, P<0.001; χ²=51.989, P<0.001). Conclusions The detection rate of opportunistic screening and the rate of early diagnosis for upper gastrointestinal cancer in Guangxi in 2019 are not high. It is necessary to further improve the awareness of cancer prevention for the public, especially the male over 40 years old.

Key words: Upper gastrointestinal cancer, Esophageal cancer, Gastric cancer, Neoplastic lesions, Opportunistic screening, Early diagnosis rate