Abstract: Objective To analyze the epidemiological characteristics and disease burden of malignant tumors in Guangxi in 2018, and to provide evidence for prevention and treatment of malignant tumors. Methods According to the tumor incidence and death data reported by 36 cancer registration areas in Guangxi in 2018, the incidence, mortality and age⁃standardized rate by Chinese standard population (ASRC) were calculated to analyze the epidemiological characteristics of malignant tumors. The disability adjusted life years (DALYs) and years of life lost with premature death (YLLs) were calculated to assess the disease burden of malignant tumors. Results In 2018, a total of 55,552 new cases of malignant tumors were reported in Guangxi cancer registration areas, with a crude incidence of 222.83/105 and ASRC of 182.50/10⁵. A total of 35,001 deaths were reported, with a crude mortality rate of 140.40/10⁵ and ASRC of 110.13/10⁵. Cancers resulted in 519,489.94 DALYs in Guangxi in 2018, the DALYs rates were 2,083.79 DALYs per 100,000 persons. Liver cancer and breast cancer were the most common malignant tumors in male and female, respectively. The DALYs burden caused by liver cancer and lung cancer were the top one for malignant tumors DALYs in male and female, respectively. Leukemia, female breast cancer, liver cancer and lung cancer were the most common malignancies in children (0-14 years old), young and middle⁃aged (15-44 years old), middle⁃aged and elderly (45-64 years old) and elderly (65 years old and above), respectively. The incidence and mortality rates of lung cancer, female breast cancer, colorectal cancer and prostate cancer in urban areas were higher than those in rural areas, whereas the incidence and mortality rates of liver cancer, cervical cancer, nasopharyngeal cancer and esophageal cancer in rural areas were higher than those in urban areas. Conclusions Liver cancer, lung cancer, colorectal cancer, female breast cancer and cervical cancer are still the major malignant tumors in Guangxi. The malignant tumor burden of Guangxi residents is still serious, the differences of region, gender and age in cancer burden are obvious , and the prevention and control situation of malignant tumor is serious.

Key words: Malignant tumor, Incidence rate, Mortality rate, DALYs, Disease burden