Abstract: The 2025 American Society of Clinical Oncology⁃Gastrointestinal Cancers Symposium (ASCO⁃GI) , convened in San Francisco, USA，　from January 23 to 25, 2025,  focused on pivotal topics within the fields of liver cancer, biliary tract cancer, and pancreatic cancer. Key areas of discussion included immunotherapy, targeted therapy, the integration of locoregional and systemic therapy, and precision medicine,  all underscoring numerous research findings of significant clinical relevance. These studies provide new evidence⁃based insights for the diagnosis and treatment of hepatobiliary and pancreatic tumors, offering valuable references for addressing unresolved clinical challenges and optimizing therapeutic strategies. This article systematically reviews the cutting⁃edge advancements in hepatobiliary and pancreatic tumors reported in ASCO⁃GI 2025, conducts an in⁃depth analysis of their clinical application value, and explores future research directions.

Key words: Liver cancer, Bilianry tract cancer, Pancreatic cancer, The 2025 American Society of Clinical Oncology?Gastrointestinal