Abstract: Objective To investigate the relationship between serial drug sensitivity or resistance to liver cancer cells and peripheral leucocytes,lymphocytes and granulocytes.Methods The sensitivity or resistance of 10 kinds of anticarcinogen for peripheral leucocytes,lymphocytes,granulocytes and the tumor cells from 31 cases of liver cancer were tested by the MTT assay. Results Except HCPT,the inhibition rates of the tested drugs in the cancer cells were apparently higher than that in the leucocytes, lymphocytes and granulocytes.The sensitivity of the top 5 anticarcinogen in cancer cells,leucocytes and lymphocytes were approximately.The correlativity between the inhibition rates of arbitrary two sets cells were all significant(P<0.01). Conclusion It was feasible to detect the sensitivity or resistance of peripheral leucocytes and lymphocytes of liver cancer patients. It could provid practical and valuable reference to optimize the individual treatment in liver cancer chemotherapy.

Key words: Liver cancer, Chemotherapy, Chemosensitivity test