Abstract: Objective To explore the effects of different therapies in patients with postoperative recurrent primary hepatic carcinoma （PHC）. Methods Clinical data of 246 postoperative recurrent PHC patients were analyzed retrospectively.Of these，18 underwent hepatectomy again，20 underwent hepatectomy again combined with comprehensive therapy，62 were treated with transcatheter arterial chemoembolization（TACE），and 146 were given conservative therapy. Results Survival rates in the 1st，3rd and 5th years were 76.3%，39.4% and 25.8% for patients who underwent hepatectomy again，compared to 53.2%，19.6% and 9.3% for patients treated with TACE. The corresponding rates for patients given conservative therapy were 37.7%，8.0% and 1.5%.The survival rates differed significantly among the three groups（P＜0.05）. Conclusions Secondary surgical resection is still the preferred method for recurrent PHC，and surgical excision combined with comprehensive treatment is the best treatment.It is associated with higher survival rate and tumor-free survival，lower intrahepatic PHC relapse，and longer survival time.

Key words: Liver neoplasms, Recurrence, Transcatheter arterial chemoembolization, Surgery, Comprehensive treatment, Efficacy