Abstract: Objective  To explore the prognostic value of platelet to lymphocyte ratio（PLR） for follicular lymphoma（FL）. Methods The clinical data of 74 patients with FL admitted to Sichuan Cancer Hospital from February 2006 to December 2016 were retrospectively analyzed. The cutoff value of PLR was calculated by X-Tile 3.6.1 software，and the patients were divided into low PLR group（<186.8，n=59）and high PLR group（≥186.8，n=15） according to the cutoff value. Cox regression analysis was used to analyze the relationship between PLR and prognosis. Results The median follow-up of this study was 42 months（range：6-144 months），4 years of progression free survival （PFS） was 42.0%，and overall survival （OS） was 54.7%. The 4-year PFS of the low PLR group was longer than that of the PLR group（51.3% vs 6.7%，χ²=25.320，P<0.001），and the 4-year OS was also longer than the PLR group（65.7%  vs 8.3%， χ²=29.414，P<0.001）. Multivariate Cox regression analysis showed that PLR>186.8 was an independent risk factor for PFS（HR=3.949，95%CI：1.856-8.404，P<0.001） and OS（HR=4.795，95%CI：2.259-10.178，P<0.001）for FL patients. Further analysis demonstrated that in low risk FL patients group，median PFS and median OS of the low PLR group were significantly longer than those of the high PLR group（PFS：75.5 months vs 19.0 months，χ²=14.798，P<0.001；OS：85.5 months vs 28.0 months，χ²=13.271，P<0.001）. Similarly，in intermediate-high risk FL patients group，median PFS and median OS of the low PLR group were also significantly longer than those of the high PLR group （PFS：32.0 months vs 12.0 months，χ²=10.766，P=0.001；OS：51.0 months vs 19.0 months，χ²=13.404，P<0.001）. Conclusion PLR is associated with prognosis in patients with FL and can be used as an indicator of prognosis.

Key words: Ｇastric cancer, Ｈigh body mass index, Complication, Ｐrognosis