Abstract: Objective To investigate the expression of long-chain non-coding RNA（lncRNA） SH3PXD2A-AS1 in colon cancer tissues and its clinical significance. Methods The tumor tissues and corresponding normal tissues were collected from 40 cases of surgical resection at Guangxi Medical University Cancer Hospital. RT-PCR was used to detect the expression level of lncRNA SH3PXD2A-AS1. Colon cancer data from the TCGA database were downloaded and used to verify the relationship between the expression level of lncRNA SH3PXD2A-AS1 and the clinicopathological features and prognosis of colon cancer. Results The expression level of lncRNA SH3PXD2A-AS1 in colon cancer tissues was higher than that in normal adjacent tissues（6.53±1.62 vs 4.37±0.96，t=3.445，P=0.002）. The expression level in the M1 state was higher than that in M0 state，and the expression level of stage Ⅲ-Ⅳ was also higher than that of stage Ⅰ-Ⅱ（P<0.05），though it was not related to the overall survival（χ²=0.326，P=0.568）. Results from the TCGA database showed that lncRNA SH3PXD2A-AS1 was highly expressed in colon cancer tissues，though it was not related to the overall survival（P>0.05）. Conclusions lncRNA SH3PXD2A-AS1 is highly expressed in colon cancer tissues and related to distant metastasis of the tumor，which may become an indicator of the degree of tumor progression.

Key words: Colon cancer, lncRNA, SH3PXD2A-AS1, Prognosis, Clinical significance