Abstract:  Objective To analyze the relationship among Cyclin D1，mis-match repair （MMR），fibrinogen （FIB） and the prognosis of colon cancer. Methods The clinicopathological data of 210 patients undergoing radical resection of colon cancer were retrospectively analyzed. The expression of Cyclin D1 and MMR were detected by immunohistochemistry，the concentrations of FIB in venous blood were detected by coagulation，and the relationship between the three indicators and postoperative survival of colon cancer  patients was analyzed. Results The 1-year，3-year，5-year survival rates of colon cancer  patients with low Cyclin D1 expression were higher than those with high expression groups（Log-rank χ²=9.878，P=0.002）. The 1-year，3-year，5-year survival rates of patients with mis-match repair genes deletion （dMMR） were higher than those with mis-match repair genes complete （pMMR） （Log-rank χ²=5.138，P=0.023）. The 1-year，3-year，5-year survival rates of patients with normal FIB before surgery were higher than those with abnormal FIB（Log-rank χ²=9.490，P=0.002）. The high expression of Cyclin D1 and abnormal FIB were independent risk factors for the prognosis of colon cancer（HR=1.931，95%CI：1.131-3.296；HR=2.029，95%CI：1.170-3.519）. Conclusions Colon cancer patients with high Cyclin D1 expression，pMMR and abnormal FIB before surgery have poor prognosis.

Key words:  , Colon cancer；Cyclin D1；MMR；FIB；Prognosis