Table of Content

25 August 2020, Volume 12 Issue 4 Previous Issue    Next Issue

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Operation mode and management practice of day ward in tumor hospital TANG Weizhong 2020, 12 (4):  367-369.  doi: 10.3969/j.issn.1674-5671.2020.04.01 Abstract ( 493 )   PDF (682KB) ( 361 )   Save   Related Articles | Metrics

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Staging of nasopharyngeal carcinoma: the evolution and the suggestions for future improvement GUO Rui, MA Jun 2020, 12 (4):  370-367.  doi: 10.3969/j.issn.1674-5671.2020.04.02 Abstract ( 509 )   PDF (550KB) ( 518 )   Save Related Articles | Metrics

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Prevention and management of side effects in the late stage of intensity-modulated radiotherapy for nasopharyngeal carcinoma ZHOU Xin, HU Chaosu 2020, 12 (4):  377-383.  doi: 10.3969/j.issn.1674-5671.2020.04.03 Abstract ( 272 )   PDF (527KB) ( 434 )   Save Related Articles | Metrics

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Thoughts on individualized decision-making of precise radiochemotherapy for nasopharyngeal carcinoma HE Meilin, YI Junlin 2020, 12 (4):  384-390.  doi: 10.3969/j.issn.1674-5671.2020.04.04 Abstract ( 246 )   PDF (478KB) ( 316 )   Save Related Articles | Metrics

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Progress in the treatment of recurrent and/or metastatic nasopharyngeal carcinoma YANG Jie, LIANG Zhongguo, ZHU Xiaodong 2020, 12 (4):  391-396.  doi: 10.3969/j.issn.1674-5671.2020.04.05 Abstract ( 353 )   PDF (511KB) ( 454 )   Save Related Articles | Metrics

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A prospective,one-arm,multicenter phase Ⅱ clinical study of apatinib in maintenance therapy after chemoradiotherapy for metastatic nasopharyngeal carcinoma LI Lu, XU Peng, LAI Xin, QI Yunxiang, FAN Ming, ZHANG Peng, LI Bosen, LI Churong, MA Daiyuan, FENG Mei 2020, 12 (4):  397-402.  doi: 10.3969/j.issn.1674-5671.2020.04.06 Abstract ( 438 )   PDF (550KB) ( 191 )   PDF（mobile） (550KB) ( 87 )   Save Objective To explore the efficacy and safety of apatinib as a maintenance treatment for metastatic nasopharyngeal carcinoma after chemotherapy and/or radiotherapy. Methods The patients with metastatic nasopharyngeal carcinoma，who received chemotherapy and/or radiotherapy from April 2017 to April 2020，were selected. All the patients received apatinib 500 mg as maintenance treatment，and the efficacy and safety were observed. The Kaplan-Meier method was used to analyze the overall survival and progression-free survival. Results A total of 21 patients were enrolled，with a median age of 47 years. The median duration of apatinib medication was 4.7（range：0.6-14.1） months，the median follow-up time was 16.1（range：1.0-31.3）months，the median overall survival was 16.6 （95%CI：6.9-26.3） months，1-year survival rate was 53.2%，and the median progression-free survival was 10.8（95%CI：5.9-15.6） months，the 1-year progression-free survival rate was 31.9%. The treatment-related grade 3 adverse reactions were mainly hand-foot syndrome （9.52%），hypertension （4.76%），tired （4.76%），mouth pain （4.76%），and vomiting （4.76%）. No grade 4 adverse reactions were observed. Conclusions Apatinib maintenance treatment can be an option for metastatic nasopharyngeal carcinoma after chemotherapy and radiotherapy. It can significantly prolong progression-free survival and has controllable safety. However，further prospective studies are needed to confirm this conclusion. Related Articles | Metrics

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Effect of miR-6732-3p expression on radio-sensitivity of radio-resistant nasopharyngeal carcinoma cell line CNE-2R YANG Xiaohui, LI Kaiguo, ZHU Xiaodong, LI Ling, DU Youqin, YANG Liu, QU Song 2020, 12 (4):  403-408.  doi: 10.3969/j.issn.1674-5671.2020.04.07 Abstract ( 312 )   PDF (1094KB) ( 298 )   Save Objective To investigate the effect of miR-6732-3p expression on the radio-sensitivity of human nasopharyngeal carcinoma CNE-2R cells. Methods The expression of miR-6732-3p in CNE-2 and CNE-2R cell lines was detected by RT-qPCR. After transfection of CNE-2R cells with miR-6732-3p lentivirus，CNE-2R cells were divided into CNE-2R（normal control group）， miR-6732-3p NC （transfection control group），and miR-6732-3p inhibition（transfection group）. The expression of miR- 6732-3p in each group was detected by RT-qPCR. The proliferation ability，apoptosis ability and radio-sensitivity of cells before and after transfection were detected by CCK-8 assay，flow cytometry and cloning formation assay，respectively. Results The RT-qPCR showed that the expression level of miR-6732-3p in CNE-2R cells was significantly higher than that of CNE-2 cells（P=0.036）. After transfection of CNE-2R cells with lentivirus，the expression level of miR-6732-3p in the transfection group was lower than those in the transfection control group and the normal control group（P＜0.05）. CCK-8 assay results showed that compared with the two control groups，the cell growth of the transfection group was inhibited （P ＜0.001）；the survival fraction （SF） of the transfection group was significantly reduced under different irradiation doses（P＜0.001）. The flow cytometry detection results showed that the apoptotic rate of transfection group after non-irradiation（0 Gy） and 8 Gy irradiation was significantly increased than that of the transfection control group and the normal control group（P＜0.05）. The cloning formation assay indicated that the radiobiological parameters D0，Dq and SF2 in the transfection group were lower than those of the two control groups（P<0.05）；the SF of the transfection group was also lower than the two control groups under different irradiation doses（P＜0.001）. Conclusions Silencing miR-6732-3p expression can significantly improve the radio-sensitivity of nasopharyngeal carcinoma CNE-2R cells，providing a new idea for molecular targeted therapy of radio-resistance in nasopharyngeal carcinoma. Related Articles | Metrics

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Relationship between nutritional status and prognosis of patients with nasopharyngeal carcinoma with concurrent chemoradiotherapy ZHAO Wei, ZHANG Huaying, LAI Hao, LIN Yuan 2020, 12 (4):  409-414.  doi: 10.3969/j.issn.1674-5671.2020.04.08 Abstract ( 327 )   PDF (546KB) ( 337 )   Save Objective To investigate the relationship between nutritional status and the prognosis of nasopharyngeal carcinoma patients with concurrent chemoradiotherapy. Methods The clinical data of 134 initial treatment patients with nasopharyngeal carcinoma who received concurrent chemoradiotherapy in Guangxi Medical University Cancer Hospital from August 2010 to December 2011 was retrospective analysis. The nutritional status of patients was assessed by nutritional risk screening 2002（NRS2002） scale and patient-generated subjective global assessment（PG-SGA） scale in 3 stages，respectively，i.e.，1 week before radiotherapy （pre-treatment）， 4 weeks after radiotherapy （mid-treatment） and at the end of radiotherapy. The relationship between PG-SGA score and the clinico-pathological characteristics，overall survival（OS） and distant metastasis-free survival（DMFS） of the patients were analyzed. Results The proportion of patients with NRS2002 score≥3 in 3 stages（pre-treatment，mid-treatment and at the end of treatment） was 30.60% （41/134），75.37%（101/134），and 85.82% （115/134），respectively. The number of the qualitative grade C and B patients of PG-SGA scale gradually increased，and the PG-SGA scores in the mid-treatment and at the end of treatment were significantly worse than the pre-treatment（P<0.001）. T stage，N stage，tumor volume and each site of invasion were positively correlated with PG-SGA score（all P<0.05）. Before，during，and after treatment，the 5-year OS and DMFS of patients with different PG-SGA scores were significantly different（P<0.001）. Conclusions Patients with nasopharyngeal carcinoma are at higher risk of malnutrition before concurrent chemoradiotherapy，and their nutritional status continues to deteriorate during concurrent chemoradiotherapy，which is related to poor prognosis.   Related Articles | Metrics

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ST6GalⅠinhibits the expression of TNFR1 to regulate the apoptosis of renal clear cell carcinoma LI Qianjin, WANG Yujie, LIU Qiang, GAO Xin, BAIHE Tiya Azati 2020, 12 (4):  415-420.  doi: 10.3969/j.issn.1674-5671.2020.04.09 Abstract ( 264 )   PDF (714KB) ( 418 )   Save Objective To investigate the effect of ST6GalⅠ on the apoptosis of renal clear cell carcinoma cells and itspossible mechanism. Methods The expression of ST6GalⅠ and TNFR1 in renal clear cell carcinoma cell lines were detected byqRT-PCR and Western blot. The renal clear cell carcinoma cell lines with different expression of ST6GalⅠ were constructed，and the apoptosis level was detected by flow cytometry，and the correlation between the expression of ST6GalⅠ and TNFR1was analyzed，the expression of TNFR1 in the differentially expressed ST6GalⅠcells were detected by qRT-PCR and Westernblot，and the apoptosis level of A498 and Caki-1 cells that differentially expressed ST6GalⅠand TNFR1 were detected byflow cytometry. Results ST6GalⅠ was highly expressed in 5 renal clear cell carcinoma cell lines（P＜0.05）. The apoptosis rate of A498 cells increased after ST6Gal Ⅰ was inhibited （P＜0.01），while the apoptosis rate of Caki-1 cells reducedfor the overexpression of ST6GalⅠ（P<0.001）. TNFR1 mRNA and protein were low-expressed in 5 renal clear cell cancer celllines，and negatively correlated with ST6GalⅠmRNA and protein expression（r=-0.9667，-0.9928，all P<0.01）. The expressionof TNFR1 increased when the expression of ST6Gal Ⅰ（P<0.001） was inhibited，while the expression of TNFR1 decreased forthe overexpression of ST6GalⅠ（P<0.001）. The apoptosis rate of A498 cells after inhibition of both ST6GalⅠand TNFR1expression was lower than that of ST6GalⅠalone （P<0.01），and the apoptosis rate of Caki-1 cells after overexpression ofboth ST6GalⅠand TNFR1 was higher than that of ST6GalⅠalone （P<0.01）. Conclusions ST6GalⅠcan inhibit the apoptosis ofrenal clear cell carcinoma cell lines by inhibiting the expression of TNFR1. Related Articles | Metrics

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Effects of Linc00704 on the proliferation,migration and invasion of colorectal cancer cells CHEN Ping, LIANG Junrong, WANG Xin, LI Danxiu, WANG Qi, CAO Tianyu, ZHOU Jinchi, ZHAO Xiaodi, LU Yuanyuan, WANG Xin 2020, 12 (4):  421-425.  doi: 10.3969/j.issn.1674-5671.2020.04.10 Abstract ( 549 )   PDF (717KB) ( 480 )   Save Objective To investigate the effect of Linc00704 （long non-coding RNA 00704） on the proliferation，migration and invasion ability of colorectal cancer cells. Methods RT-qPCR was used to detect the expression of Linc00704 mRNA in the matched colorectal cancer and adjacent normal tissues，colorectal cancer cells and normal immortalized human colon epithelial cell line FHC. A low-expressing cell model of Linc00704 was constructed by antisense oligonucleotide（ASO）transfecting colorectal cancer cells，and a cell model with overexpression of Linc00704 was constructed by lentivirus infecting colorectal cancer cells. The transfection efficiency was detected by RT-qPCR，the cell proliferation was detected by CKK-8 assay，and the cell migration and invasion were measured by Transwell assay. Results Compared with the adjacent tissues，the expression of Linc00704 decreased in colorectal cancer tissues（t=4.103，P<0.001）. Among the 8 colorectal cancer cell lines，the expression of Linc00704 in 6 cell lines（RKO，HCT15，NCI-H716，SW480，SW1463，SW48）was lower than that of FHC（F=44.750，P<0.001）. Silencing the expression of Linc00704 could promote the migration and invasion of Caco-2 and DLD-1 cells （all P<0.01），but had no significant effect on the proliferation （all P>0.05）. The overexpression of Linc00704 could inhibit the migration and invasion of RKO and HCT15 cells（all P<0.001），but had no effect on the proliferation（all P>0.05）. Conclusions Linc00704 is low-expressed in colorectal cancer tissues，and overexpression of Linc00704 can inhibit the migration and invasion ability of colorectal cancer cells. Related Articles | Metrics

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Effect of sulforaphane on autophagy of human melanoma A375 cells ZHANG Xin, WANG Bohan, SUN Jian 2020, 12 (4):  426-430.  doi: 10.3969/j.issn.1674-5671.2020.04.11 Abstract ( 383 )   PDF (562KB) ( 281 )   Save Objective To investigate the effect of sulforaphane（SFN） on autophagy of human melanoma A375 cells. Methods The proliferation of A375 cells was detected by MTT assay after treated with SFN at different concentrations（0 μmol·L-1 ，5 μmol·L-1，10 μmol·L-1，20 μmol·L-1，40 μmol·L-1） and its combined autophagy inhibitor chloroquine. Theexpressions of autophagy-related molecules LC3（LC3Ⅱ/LC3Ⅰ），Beclin-1 and p62，apoptosis-related molecules Bcl-2，Bax and Caspase-3 were detected by Real-time PCR and Western blot. Results MTT assay showed that SFN inhibited the proliferation of A375 cells in a dose-dependent manner（F=21.517，P<0.001）. Compared with the control group，SFN at different concentrations（5 μmol·L-1，10 μmol·L-1，20 μmol·L-1，40 μmol·L-1） could up-regulate the expression of autophagy-related molecules LC3Ⅱand Beclin-1 mRNA，LC3Ⅱ/LC3Ⅰand Beclin-1 proteins，as well as the expression of pro-apoptotic proteins Bax and Caspase-3 （P<0.05），while down-regulated the expression of autophagy-related molecule p62 and the inhibitor of apoptosis protein Bcl-2（P<0.05）. The proliferation rate of A375 cells treated with chloroquine combined with SFN at different concentrations was lower than that treated with SFN alone（P<0.05）. Conclusions SFN can induce autophagy and promote apoptosis of melanoma A375 cells，and can enhance the inhibition of cell proliferation when combined with chloroquine，and can be an effective therapeutic for melanoma. Related Articles | Metrics

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Effects of portulaca oleracea polysaccharide on the proliferation and apoptosis of gastric cancer SGC7901 cells OU Hailing, ZHANG Xiuling, SUN Pingliang, ZHANG Xiliu, GENG Shuguang, QIN Yuzhou 2020, 12 (4):  431-434.  doi: 10.3969/j.issn.1674-5671.2020.04.12 Abstract ( 394 )   PDF (468KB) ( 327 )   Save  Objective To investigate the effects of portulaca oleracea polysaccharide on the proliferation and apoptosisof gastric cancer SGC7901 cells. Methods Gastric cancer SGC7901 cells were cultured in vitro and treated with differentconcentrations of portulaca oleracea polysaccharides（25 μg/mL，50 μg/mL，100 μg/mL，200 μg/mL，300 μg/mL）. Normalsaline was used as the negative control group and 5-FU as the positive control group. The cell proliferation was detectedby MTT assay，and apoptosis was detected by flow cytometry. Results The proliferation inhibition rate of SGC7901 cellstreated with portulaca oleracea polysaccharide at different concentrations increased with the increases of duration timeand drug concentration. After 48 h，the proliferation inhibition rates of 200 μg/mL and 300 μg/mL portulaca oleracea polysaccharide groups were（53.02±2.46）%，（57.20±2.14）%，respectively，which were comparable to those of the 5-FU group，（56.36±3.26）% （P>0.05）. The apoptosis rates of each concentration group were significantly increased compared with the negative control group，followed by 31.92%，38.39%，40.45%，48.49%，55.71%（all P<0.05）. Compared with the 5-FU group，the apoptosis rates of low-concentration（25 μg/mL，50 μg/mL，and 100 μg/mL） groups were decreased（P<0.05）， while the apoptosis rate was increased in the high concentration（300 μg/mL） group（P<0.05）. Conclusions Portulaca oleracea polysaccharide can inhibit the proliferation and induce the apoptosis of gastric cancer SGC7901 cells. Portulaca oleracea polysaccharide can inhibit the proliferation and induce the apoptosis of gastric cancer SGC7901 cells. Related Articles | Metrics

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Correlation analysis of Cyclin D1，MMR，FIB and prognosis of colon cancer GUAN Gaowa, MA Xiao, SI Hai, WANG Jingting, ZHANG Xinhong, LU Zejun, CAO Bangwei 2020, 12 (4):  435-440.  doi: 10.3969/j.issn.1674-5671.2020.04.13 Abstract ( 222 )   PDF (765KB) ( 356 )   Save  Objective To analyze the relationship among Cyclin D1，mis-match repair （MMR），fibrinogen （FIB） and the prognosis of colon cancer. Methods The clinicopathological data of 210 patients undergoing radical resection of colon cancer were retrospectively analyzed. The expression of Cyclin D1 and MMR were detected by immunohistochemistry，the concentrations of FIB in venous blood were detected by coagulation，and the relationship between the three indicators and postoperative survival of colon cancer  patients was analyzed. Results The 1-year，3-year，5-year survival rates of colon cancer  patients with low Cyclin D1 expression were higher than those with high expression groups（Log-rank χ2=9.878，P=0.002）. The 1-year，3-year，5-year survival rates of patients with mis-match repair genes deletion （dMMR） were higher than those with mis-match repair genes complete （pMMR） （Log-rank χ2=5.138，P=0.023）. The 1-year，3-year，5-year survival rates of patients with normal FIB before surgery were higher than those with abnormal FIB（Log-rank χ2=9.490，P=0.002）. The high expression of Cyclin D1 and abnormal FIB were independent risk factors for the prognosis of colon cancer（HR=1.931，95%CI：1.131-3.296；HR=2.029，95%CI：1.170-3.519）. Conclusions Colon cancer patients with high Cyclin D1 expression，pMMR and abnormal FIB before surgery have poor prognosis.   Related Articles | Metrics

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Analysis of RSK1 expression in breast cancer and its prognostic value based on bioinformatics method LIU Sinan, LONG Yunxiang, GAO Jie, WANG Zheng, LIU Chang, HUANG Qichao, LIN Ting 2020, 12 (4):  441-446.  doi: 10.3969/j.issn.1674-5671.2020.04.14 Abstract ( 462 )   PDF (606KB) ( 353 )   Save  Objective To investigate the expression of ribosomal S6 protein kinase type 1 （RSK1） in breast cancer and its prognostic value. Methods The RSK1 expressions in breast cancer tissues and normal breast tissues were compared based on the Protein Atlas database. The RSK1 mRNA expression data were extracted from TCGA-BRCA and GEO database，the RSK1 protein expression data were obtained from TCGA-RPPA database，to analyze the RSK1 mRNA and protein expression and its relationship with the overall prognosis of breast cancer. Results The immunohistochemical analysis of the dataset showed that the expression level of RSK1 protein in breast cancer tissues was lower than that in normal tissues. The univariable and multivariable Cox regression analysis of TCGA-BRCA database showed that the patients with high level of RSK1 mRNA had a better prognosis. The results of stratified analysis showed that female patients，age≤60 years，StageⅠ-Ⅱ，infiltrating carcinoma，no regional lymph node metastasis （N0），and no distant metastasis（M0） with high expression of RSK1 mRNA had a better prognosis. The meta-analysis results of 9 microarray datasets of GEO database was consistent with the TCGA-BRCA database（HR=0.69，95%CI：0.56-0.86，P=0.002）. The TCGA-RPPA data showed that the patients with high RSK1 protein level had a better prognosis（HR=0.49，95%CI：0.27-0.89，P=0.011），and the patients in different stages of breast cancer with high expression of RSK1 mRNA and protein were associated with better prognosis（HR=0.61，95%CI：0.39-0.95，P=0.025；HR=0.43，95%CI：0.22-0.84，P=0.008）. Conclusions High expression of RSK1 is associated with a better overall prognosis of breast cancer patients，and RSK1 can be a biomarker to predict the overall prognosis for breast cancer，especially for patients at early stage. Related Articles | Metrics

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Association between HJURP gene polymorphism and the efficacy and adverse reactions of oxaliplatin-based chemotherapy for advanced hepatocellular carcinoma WEI Lingchun, LIAO Xiaoli, HUANG Wenfeng, LIAO Sina, LIU Zhihui, LI Yongqiang 2020, 12 (4):  447-452.  doi: 10.3969/j.issn.1674-5671.2020.04.15 Abstract ( 323 )   PDF (414KB) ( 231 )   Save Objective To investigate the association between holliday junction recognition protein（HJURP） gene polymorphism and oxaliplatin-based chemotherapy efficacy and adverse reactions in the first-line treatment for patients with advanced hepatocellular carcinoma（HCC）. Methods The clinical data and peripheral blood samples of 42 patients with advanced HCC received first-line treatment with oxaliplatin-based chemotherapy in Guangxi Medical University Cancer Hospital were collected. The next-generation sequencing（NGS） technology was used to classify the 7 loci of HJURP gene，and the relationship between gene polymorphism and chemotherapy efficacy，prognosis and adverse reactions was analyzed. Results Disease control rate（DCR）of 42 patients was 21.4%，and the polymorphism of HJURP gene was not related to DCR（P＞0.05）. The median progression-free survival（mPFS） was 1.5 months and the median overall survival（mOS） was 4.4 months. The mOS of patients carrying rs3771333 loci with A/A genotype was longer than those with A/C genotype（6.0 months vs 1.3 months，P=0.016）. The polymorphism of HJURP gene was not associated with hematotoxicity，gastrointestinal toxicity and neurotoxicity of oxaliplatin-based chemotherapy. Conclusions The rs3771333 polymor-phism of HJURP gene is associated with the prognosis of oxaliplatin-containing regimens in the treatment of advanced HCC，and patients with A/A genotype have better prognosis. Related Articles | Metrics

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Pathological features and clinical analysis of neuroendocrine carcinoma of nasopharynx WANG Hao, WEI Zhengbo 2020, 12 (4):  453-457.  doi: 10.3969/j.issn.1674-5671.2020.04.16 Abstract ( 617 )   PDF (673KB) ( 394 )   Save Objective To investigate the clinicopathologic features，immunohistochemical characteristics，treatment and prognosis of neuroendocrine carcinoma（NEC） of nasopharynx. Methods The clinical and pathological data of 12 NEC patients were retrospectively analyzed，and relevant literature was reviewed. Results Among the 12 patients，10 were males and 2 were females，with an average age of 49.42 years. The pathologic types were all small cell type NEC. Under electron microscope，small tumor cells could be seen，which were round，oval and fusiform shaped，respectively，with hyperchromatic nuclei，less cytoplasm and high nucleolar ratio，accompanied by obvious pathological mitosis and fine chromatin. Immunophenotype：CgA，Syn，CD56，EBERs positive or partially positive were 6 cases，10 cases，9 cases，and 3 cases，respectively. There were 1 case in stage Ⅰ，1 case in stage Ⅱ，4 cases in stage Ⅲ，5 cases in stage Ⅳ，and 1 case in unknown clinical stage. All patients received radiotherapy and/or chemotherapy，and 9 cases survived and 3 cases died in the end of follow-up. Conclusions Neuroendocrine carcinoma of nasopharynx is relatively rare clinically，mostly occurring in middle-aged and elderly male. The pathological type is mainly small cell type and prone to cervical lymphatic metastasis. Most of the patients are in the middle and advanced stage at the time of treatment，and the treatment is mainly radiotherapy and chemotherapy. Related Articles | Metrics

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Association between PSCA gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population：a meta-analysis QIN Siyuan, LI Chenghao 2020, 12 (4):  457-462.  doi: 10.3969/j.issn.1674-5671.2020.04.17 Abstract ( 292 )   PDF (743KB) ( 377 )   Save Objective To evaluate the association between prostate stem cell antigen（PSCA） gene rs2976392 polymorphism and sus-ceptibility of gastric cancer in Chinese population. Methods Databases including CKNI，Wanfang，VIP，NCBI，Embase，and Web of Science were searched to identify the literatures concerning the association between PSCA gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population from the inception to March 22，2020. Meta-analysis was performed using RevMan 5.3 and Stata 12 software after quality assessment. Results A total of 14 case-control studies from 13 literatures were included，involving 6 618 gastric cancer cases and 6 952 controls. The meta-analysis results of allele model（A vs G），dominant gene model（AA+GA vs GG） and a codominant gene model（AA vs GG） all showed that the PSCA gene rs2976392 polymorphism was associated with an increased risk of gastric cancer in the Chinese population （OR=1.28，95%CI：1.08-1.52，P=0.004；OR=1.35，95%CI：1.27-1.45，P＜0.001；OR=1.51，95%CI：1.03-2.20，P=0.030）. The subgroup analysis showed that all the gene models were associated with an increased risk of gastric cancer in Han population（all P＜0.001），but in Tibetan population，all genetic models showed no obvious correlation（all P＞0.05）. Conclusions PSCA gene rs2976392 polymorphisms is associated with an increasing risk of gastric cancer in  Chinese population，and the risk of gastric cancer in the Han population homozygous for the AA genotype is highest. Related Articles | Metrics

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Recent progress in multidisciplinary treatment based on surgery for patients with esophageal squamous cell carcinoma HUANG Chujian, CAI Songhua, DU Longde, MA Kai 2020, 12 (4):  463-468.  doi: 10.3969/j.issn.1674-5671.2020.04.18 Abstract ( 315 )   PDF (375KB) ( 389 )   Save   Related Articles | Metrics

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Research progress on the relationship between breast density and breast cancer in Chinese and western women PENG Fangfang, SHEN Kunwei 2020, 12 (4):  469-474.  doi: 10.3969/j.issn.1674-5671.2020.04.19 Abstract ( 334 )   PDF (381KB) ( 604 )   Save Related Articles | Metrics

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Clinical research progress of immunotherapy for hepatocellular carcinoma XIAO Huimin, YANG Zhendong 2020, 12 (4):  474-480.  doi: 10.3969/j.issn.1674-5671.2020.04.20 Abstract ( 294 )   PDF (408KB) ( 376 )   Save Related Articles | Metrics

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Research progress of artificial intelligence in nasopharyngeal carcinoma imaging XIE Dong, LI Yin, JIN Guanqiao 2020, 12 (4):  481-484.  doi: 10.3969/j.issn.1674-5671.2020.04.21 Abstract ( 358 )   PDF (350KB) ( 522 )   Save Related Articles | Metrics