Abstract: Objective  To observe the clinical effect of microwave ablation combined with percutaneous vertebroplasty(PVP) in the treatment of lumbar metastases（MWA）. Methods A retrospective analysis was performed on the clinical data of 50 patients with metastatic tumors of the lumbar vertebrae admitted to Guangxi Medical University Cancer Hospital from June 2016 to June 2019, including 26 cases of percutaneous vertebroplasty (PVP group), and percutaneous microwave ablation combined 24 cases of skin vertebroplasty (PVP+MWA group). The pain, functional status, bone cement extravasation and postoperative tumor recurrence rate of the two groups of patients were observed. Results Followed up for 6 to 36 months, the VAS score of the PVP group decreased from (7.58±1.06) points before the operation to(3.27±1.40) points 1 month after the operation and(3.08±1.60) points 6 months after the operation; the PVP+MWA group reduced from(7.67±1.05) points before the operation to(3.04±1.20) points 1 month after surgery and(2.96±1.46) points 6 months after surgery. VAS scores of the two groups at 1 month and 6 months after surgery were lower than those before surgery (all P<0.05), but the variance of repeated measurements showed that no statistically significant difference between two groups(F=0.223, P=0.801). One month after surgery, the KPS score of the PVP group was increased by (21.50±11.32) points than that of the preoperative, and the KPS score of the PVP+MWA group was increased by (19.92±13.19) points than that of the preoperative, but there was no statistically significant difference (t=0.457, P=0.650). The bone cement exosmosis rate (12.5% vs 38.5%, P=0.037) and tumor recurrence rate (8.3% vs 30.8%, P=0.048) in PVP+MWA group were both lower than those in PVP group. Conclusions Percutaneous vertebroplasty alone or in combination with microwave ablation can achieve better clinical effects in the treatment of lumbar metastases. The combination of the two has advantages in the reduction of bone cement extravasation and local tumor control.

Key words:  , Spinal metastases, Metastasis, Minimally Invasive, Microwave, Percutaneous vertebroplasty