Abstract:  Objective To analyze the incidence and mortality of female breast cancer in the registration areas of Gansu province from 2009 to 2015. Methods The crude incidence (mortality) rate, age-specific incidence (mortality) rate, cumulative rate (0-74 years old) and standardized incidence (mortality) rate were calculated based on the breast cancer data reported by the cancer registration areas in Gansu province from 2009 to 2015. The age standardized rates were calculated according to the Chinese population census in 2000 (ASR China) and Segi's standard population (ASR world). The annual percent change (APC) was calculated by Joinpoint 4.7 software. Results A total of 4, 980 new cases of breast cancer were reported in cancer registration areas of Gansu province from 2009 to 2015 with a crude incidence rate of 27.14/10⁵, the ASR China of 22.84/10⁵, and the ASR world of 23.56/10⁵. There were 895 deaths by breast cancer, the crude mortality rate was 8.72/10⁵, the ASR China was 7.61/10⁵, and the ASR world was 8.00/10⁵. The crude incidence rate of breast cancer in urban area was 28.59/10⁵, the ASR China was 23.69/10⁵, and the ASR world was 24.54/10⁵. The crude incidence rate in rural area was 24.27/10⁵, the ASR China was 22.08/10⁵, and the ASR world was 22.15/10⁵. The crude mortality rate of breast cancer in the urban area was 10.13/10⁵, the ASR China was 8.34/10⁵, and the ASR world was 8.71/10⁵. The crude mortality rate of breast cancer in rural area was 4.70/10⁵, the ASR China was 5.79/10⁵, and the ASR world was 6.15/105. The high risk group of age-specific incidence was the 50-year old group, and the high risk group of age-specific mortality was the 80-year old group, and the age-specific incidence and mortality rates increased with age. From 2009 to 2015, the incidence (APC=-3.8%, 95%CI: -10.5% to 3.5%) and mortality (APC=-10.1%, 95%CI: -24.9% to 7.6%) of ASR China of breast cancer in Gansu province decreased slightly, but the change of trend was not statistically significant (P>0.05). Conclusions From 2009 to 2015, the trend of female breast cancer incidence and mortality in Gansu province was stable, but the incidence and mortality in urban areas were higher than those in rural areas, and the middle-aged and elderly women were high-risk groups.

Key words: Breast cancer, Incidence, Mortality, Cancer registration, Change trend, Gansu