Abstract: Objective To investigate the epidemiologic factors influencing the negative conversion after human papilloma virus (HPV) infection. Methods The data of 511 patients with HPV infection treated in the First Hospital of Shanxi Medical University from January 2020 to February 2020 were collected, and the factors influencing the negative conversion after HPV infection were analyzed by using univariable and multifactorial logistic regression. Results Among 511 patients with HPV infection, 244 (47.75%) patients showed negative conversion after HPV infection (conversion group) and 267 (52.25%) patients showed persistent infection (non-conversion group). The results of sleep assessment showed that the overall sleep status of all enrolled patients was poor, with an average SRSS score of (26.23±5.75) point, in which the contributions of physiological and psychological reaction after insomnia, insufficient sleep time and difficulty in falling asleep were higher than other factors. Univariable analysis showed that the key factors including circadian rhythm (age, sleep quality, anxiety state), sexual frequency, pregnancy time and work status were associated with negative conversion after HPV infection(all P<0.05). In the conversion group, 61.07% (149/244) of the patients reported poor recent sleep quality, while 81.27% (217/267) of the patients in the non-conversion group reported poor recent sleep quality. The difference between the two groups was statistically significant (P<0.001). Multivariable logistic regression showed that recent sleep quality and drug intervention were independent influencing factors of negative conversion after HPV infection. Good recent sleep quality was a protective factor of negative conversion after HPV infection, and the probability of negative conversion after HPV infection in patients with good sleep quality was 1.861 times higher (OR=2.861, 95%CI: 1.735-4.715). In terms of pharmacological interventions, the application of rebacin (OR=0.444, 95%CI: 0.299-0.662) or interferon (OR=0.080, 95%CI: 0.031-0.206) was more conducive to the negative conversion after HPV infection, and the rebacin was more effective. Conclusions Patients with HPV infection generally have poor recent sleep quality. The key factors of circadian rhythm such as sleep quality and anxiety can affect the negative conversion after HPV infection, and improving recent sleep quality and proper mental guidance can help clear the HPV in the infected people.

Key words: Cervical cancer, HPV infection, Circadian rhythm, Sleep