Abstract: This article presents a rare case of typeⅡcryoglobulinemia secondary to mucosa⁃associated lymphoid tissue (MALT) lymphoma. The patient exhibited recurrent pharyngeal masses， skin purpura， and edema. The diagnosis of MALT lymphoma， involving the nasopharynx， oropharynx and bone marrow， was confirmed through a biopsy of the nasopharyngeal mass， supplemented by histopathological and immunohistochemical analysises. TypeⅡcryoglobulinemia was subsequently diagnosed using immunofixation electrophoresis. Following eight cycles of R⁃CHOP chemotherapy and Entecavir antiviral therapy， the patient achieved symptomatic remission. This report investigates the association between MALT lymphoma and cryoglobulinemia， analyzing the etiology， diagnosis， and treatment of cryoglobulinemia. The case underscores the importance of considering cryoglobulinemia in patients with multi⁃organ involvement. Even when mixed cryoglobulinemia is diagnosed， it is imperative to screen for underlying lymphoma， particularly marginal zone B⁃cell lymphoma， to inform personalized therapeutic strategies.

Key words: Cryoglobulinemia, Marginal zone B?cell lymphoma, Mucosa?associated lymphoid tissue lymphoma, Hepatitis B virus