Abstract:

Objective  To explore the correlation between hepatitis B virus（HBV） genotype and subgenotype and hepatocellular carcinoma in China. Methods A case control study on the correlation between Chinese HBV genotypes，subgenotype and hepato-cellular carcinoma，published from January 2007 to February 2017，was retrieved in a comprehensive retrieval system. The literature was selected and the quality was evaluated and effective data were extracted according to the exclusion criteria. The Meta analysis was analyzed by RevMan 5.3 analysis. Results Finally，37 studies were included in the study of HBV genotype and hepatocellular carcinoma，4，109 cases in case group，15，319 in control group；8 in HBV gene subtype（C1，C2，B2） with hepatocellular carcinoma，931 in case group and 5，793 in control group，and the quality score of the included literature was more than 7. The results of Meta analysis showed that：⑴the risk of HBV C genotype was higher than that of genotype B（OR=2.35，95%CI：1.93-2.87，P＜0.001）；there was no significant difference in the risk of hepatocellular carcinoma of HBV C and A，D subgenotype（OR=1.25，95%CI：0.20-7.82，P=0.81）； ⑵there was no significant difference in the risk of hepatocellular carcinoma of HBV C1 and C2 subgenotype（OR=1.05，95%CI：0.66-1.68，P=0.82），and the risk of hepatocellular carcinoma in HBV C2 subgenotype is stronger than that of B2 subgenotype（OR=1.77，95%CI：1.38-2.27，P＜0.001）. Conclusions HBV genotype C has higher risk of liver cancer than other major genotypes. There is no significant difference in the risk of hepatocellular carcinoma in HBV C1 and C2 subgenotype，but the risk of hepatocellular carcinoma is higher in HBV C2 subgenotype than that in B2 subgenotype.

Key words:  Liver neoplasms, Hepatitis B virus, Genotype, Subgenotype, Meta-analysis, China