Abstract:

Objective To investigate the relationship between serum adiponectin and type I endometrial cancer. Methods Medical records were retrospectively reviewed for 34 patients with newly diagnosed endometrial cancer and 24 women with normal endometrium at the Affilated Tumor Hospital of Guangxi Medical University. The two groups were compared in terms of serum adiponectin，fasting serum insulin（FINS），and fasting blood glucose（FBG）. Logistic regression was used to explore relationships between serum adiponectin levels and type I endometrial cancer. Results Serum adiponectin levels in patients were independent of clinico-pathological features such as surgical stage，pathology grade，myometrial invasion，cervical involvement，and lymph node metastasis（P>0.05）. The control group showed a high adiponectin level. Univariate logistic regression showed that relative to individuals with high adiponectin levels，those with low adiponectin levels were at significantly higher risk of endometrial cancer（OR=8.125，95%CI：1.874-35.233，P=0.005）， as were those with intermediate adiponectin levels（OR=4.024，95%CI：1.060-15.278，P=0.041）. Similar results were obtained after adjusting for fasting insulin levels or HOMA-IR index. Conclusion Risk of endometrial cancer seems to vary inversely with serum adiponectin level. Low serum adiponectin levels may promote the development of endometrial cancer.

Key words: Endometrial neoplasms, Fasting serum adiponectin, Correlation, Logistic regression, Risk