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25 August 2022, Volume 14 Issue 4 Previous Issue    Next Issue

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Expert consensus on clinical application of biomarkers for precision treatment of breast cancer based on target guidance(2022 edition) The Expert Board of Breast Cancer Biomarkers, Tumor Marker Committee of Chinese Anti⁃cancer Association 2022, 14 (4):  346-362.  doi: 10.3969/j.issn.1674-5671.2022.04.01 Abstract ( 3917 )   PDF   Save Related Articles | Metrics

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Method and progress of constructing mouse primary liver cancer model of high⁃pressure hydrodynamic injection gene transfection HONG Xin, GAO Mingshu, XU Xiaojun, WEI Yuanyuan, LI Xiaolei, HUANG Qichao 2022, 14 (4):  363-369.  doi: 10.3969/j.issn.1674-5671.2022.04.02 Abstract ( 3051 )   PDF   Save Related Articles | Metrics

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The role of lncRNA BCYRN1 in activation of glycolysis in extranodal NK/T⁃cell lymphoma and its mechanism FU Ruiying, LIU Xindi, LIANG Yuanzheng, LIU Xuelin, WANG Liang 2022, 14 (4):  370-377.  doi: 10.3969/j.issn.1674-5671.2022.04.03 Abstract ( 240 )   PDF   Save Objective To investigate the role of long non-coding RNA (lncRNA) BCYRN1 in activation of glycolysis in extranodal NK/T-cell lymphoma (ENKTCL)  and its mechanism. Methods The data of 236 ENKTCL patients who were diagnosed and treated in Beijing Tongren Hospital from 2010 to 2021 were collected to analyze the correlation between fasting blood glucose (FBG) and progression-free survival (PFS). The content of BCYRN1 in the 32 newly diagnosed ENKTCL patients was detected by qRT-PCR, and the correlation between BCYRN1 and PFS was analyzed. The SNK-6 cell lines with overexpression of BCYRN1 (OE-BCYRN1 group) and interference of BCYRN1 (shBCYRN1 group) were constructed by the plasmid transfection method. The Screen Quest- colorimetric method was used to detect glucose uptake, and lactate production was detected by Lactic Acid assay kit. The expression levels of PKM2, HIF-1α, SLC2A1, LDHA and PDK1 were detected by qRT-PCR and Western blot, and the protein synthesis inhibitor, lysosomal inhibitor or activator were added to observe the effect of BCYRN1 on PKM2 stability. The RNA pull-down and RIP experiments were used to determine the interaction mode between BCYRN1 and PKM2. Results Among 236 ENKTCL patients, 49 were in the hyperglycemia group (FBG>5.6 mmol/L) and 187 were in the normal group (FBG≤5.6 mmol/L). The 5-year PFS rate in the hyperglycemia group was lower than that in the hypoglycemia group (32.1% vs 63.7%, P<0.001). The 3-year PFS in the high BCYRN1 expression group was lower than that in the low expression group ( 26.1% vs 82.5%, P=0.014). After interference with BCYRN1, the glucose intake and lactate production level of ENKTCL SNK-6 cells were significantly decreased (all P<0.05). After overexpression of BCYRN1, the expression levels of PKM2, HIF-1α, SLC2A1, LDHA and PDK1 were significantly increased (all P<0.05). After treatment of SNK-6 cells with protein synthesis inhibitor (Cycloheximide) for 3 h or 6 h, the degradation rate of PKM2 in OE-BCYRN1 group was significantly lower than that in OE-CTRL group (all P<0.05), and the degradation ratio of PKM2 in the shBCYRN1 group was significantly higher than that in the shCTRL group. After lysosomal inhibitor (Leupeptin) treatment, PKM2 degradation ratio in shBCYRN1+Leupeptin group decreased significantly (P<0.01); while the degradation ratio of PKM2 in OE-BCYRN1+6-AN group was significantly increased after treatment with lysosome activator (6-Aminonicotinamide)(P<0.01). The RNA pull-down and RIP experiments showed that BCYRN1 gene could interact directly with PKM2 protein. Conclusions BCYRN1 may activate ENKTCL glycolysis pathway by up-regulating PKM2 expression through the lysosomal pathway. Related Articles | Metrics

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Mechanism of PGRMC1 promoting breast cancer cell proliferation during hormone therapy ZHAO Yue, RUAN Xiangyan, GU Muqing, XU Xin, CHENG Jiaojiao 2022, 14 (4):  378-387.  doi: 10.3969/j.issn.1674-5671.2022.04.04 Abstract ( 252 )   PDF   Save Objective To investigate the mechanism of progesterone receptor membrane components 1(PGRMC1) promoting the proliferation of breast cancer cells during hormone therapy. Methods Estrogen receptor (ER) -positive breast cancer MCF7 cells were treated with estrogen and progesterone, and then infected with chronic disease venom overexpressing PGRMC1, knockdown ER prohibitin(shPHB1-1 and shPHB1-2) and their corresponding negative controls. The interaction between PGRMC1 and PHB complex (PHB1 and PHB2) was detected by co-immunoprecipitation combined with mass spectrometry and GST pull-down assay. The expressions of PHB1, PHB2 and PGRMC1 were detected by Western blot and RT-qPCR. The cell proliferation ability was detected by CCK-8 and EDU assay. Flow cytometry was used to detect the cell cycle, and RT-qPCR was used to detect the expression of downstream target genes of ER signaling pathway, including THBS1, CXCL12 and GREB1. Results Co-immunoprecipitation combined with mass spectrometry analysis showed that both PHB1 and PHB2 were present in the co-immunoprecipitation fraction of PGRMC1. GST pull-down identified a direct interaction between PGRMC1 and PHB complex in vitro. Compared with the control group, the proliferation rate of breast cancer cells overexpressing PGRMC1 and down-regulating PHB1 was significantly accelerated (all P<0.05), the proportions of positive cells in S and G2/M phases were significantly increased (all P<0.05), and the expressions of THBS1, CXCL12 and GREB1 in the downstream target genes of ER signaling pathway were significantly promoted (all P<0.01). The interaction between PHB1 and ER in MCF7 cells was attenuated after PGRMC1 overexpression. The proportion of positive cells in S and G2/M phases after down-regulating PHB1 and then overexpressing PGRMC1 had no significant change compared with that of down-regulating PHB1 alone (all P>0.05). Conclusions PGRMC1 may relieve the inhibitory effect of PHB complex on the ER signaling pathway by binding to PHB complex, thereby promoting the activation of the ER signaling pathway and the expressions of downstream target genes, and accelerating the malignant proliferation of breast cancer cells under hormone stimulation. Related Articles | Metrics

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Trends of cancer incidence,mortality and disease burden in Binyang county,Guangxi,2014—2018 WEIJunjie, GANXiaoqin, WEILiuqing, CHENWeiqiang, ZHOUZihan, XINGZhaoqiong, LIQiulin, YUJiahua, RONGMinhua, CAOJi, GELianying, TANGWeizhong, ZHOUXianguo, YUHongping 2022, 14 (4):  385-392.  doi: 10.3969/j.issn.1674-5671.2022.04.05 Abstract ( 201 )   PDF   Save Objective To analyze the developing trends of cancer incidence, mortality and disease burden in Binyang county, Guangxi, from 2014 to 2018, and to provide reference for developing cancer prevention and treatment strategies. Methods The incidence and mortality data of cancer in Binyang county, Guangxi, from 2014 to 2018 were collected, the crude incidence rate, crude mortality rate, age?standardized incidence and mortality rate by Chinese standard population (ASIRC and ASMRC) and world population (ASIRW and ASMRW) were calculated, and the incidence and mortality of cancer were analyzed. The years of lived with disability (YLDs), years of life lost (YLLs) and disability?adjusted life years (DALYs) were used to assess the disease burden caused by cancer. The Joinpoint regression model was used to estimate the average annual percent change (AAPC) of cancer incidence, mortality and DALYs rate, and to evaluate the trends. Results From 2014 to 2018, a total of 11, 536 new cases of cancer were reported in Binyang county, with a crude incidence rate of 219.64/105, anregression model was used to estimate the average annual percent change (AAPC) of cancer incidence, mortality and DALYs rate, and to evaluate the trends. Results d ASIRC of 180.25/105. A total of 6, 970 deaths were reported, with a crude mortality rate of 132.70/105, and ASMRC of 103.44/105. The crude incidence rate of cancer in Binyang county showed an increasing trend from 2014 to 2018, though the difference was not statistically significant (AAPC=9.88%, t=2.11, P=0.125). The crude mortality rate increased from 103.08/105 in 2014 to 149.35/105 in 2018, with an average annual increase of 10.83% (AAPC=10.83%, t=4.03, P=0.027). The cancers of liver, lung, female breast, colorectum, cervix, gastric, nasopharynx, esophagus, brain and thyroid were the top ten for cancer incidence, accounting for 81.33% of the total cancers. The cancers of liver, lung, gastric, female breast, colorectum, nasopharynx, cervix, esophagus, brain and leukemia were the ten leading causes of cancer deaths, accounting for 86.11% of the total cancers. Cancers resulted in 108, 848.61 DALYs in Binyang county from 2014 to 2018, the DALYs rate was 2, 072.40 DALYs per 105 persons. The DALYs rate of cancer increased from 1, 637.17/105 in 2014 to 2, 366.51/105 in 2018, with an average annual increase of 10.87% (AAPC=10.87%, t=4.72, P=0.018).The top ten cancers in DALYs rate were the cancers of liver, lung, female breast, gastric, colorectum, nasopharynx, cervix, brain, leukemia and uterus. Conclusions From 2014 to 2018, the incidence, mortality and DALYs rates of cancer in Binyang county, Guangxi province are relatively high, and the mortality and DALYs rates showed a growth trend. The main cancers in Binyang county, include liver cancer, lung cancer, female breast cancer, gastric cancer, colorectal cancer, nasopharynx cancer and cervix cancer, which deserve more prevention and control effort. Related Articles | Metrics

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Correlation of clinical axillary lymph node⁃positive ultrasound features with lymph node metastasis burden and prognosis in breast cancer LI Zhuoxuan, TONG Yiwei, CHEN Xiaosong, SHEN Kunwei 2022, 14 (4):  393-399.  doi: 10.3969/j.issn.1674-5671.2022.04.06 Abstract ( 222 )   PDF   Save Objective To analyze the ultrasound features of patients with clinical axillary lymph node-positive breast cancer, and to explore the correlation of ultrasound features with lymph node metastasis burden and prognosis. Methods The patients with clinical node-positive disease who underwent axillary lymph node dissection in our center between January 2009 and December 2020 were included. The clinicopathological and ultrasonographic indicators that could predict the lymph node metastasis burden were retrospectively analyzed. Multivariable Cox regression was used to explore the ultrasonographic predictors affecting the prognosis. Results A total of 1,055 breast cancer patients were included in the study, including 398 patients (37.7%) with low nodal burden (1-2 lymph node metastases) and 657 patients (62.3%) with high nodal burden (≥3 lymph node metastases). Multivariable analysis indicated that the age of patients ≥55 years old (OR=1.56, 95%CI: 1.20-2.02, P=0.001), the ultrasound tumor size <20.0 mm (OR=1.54, 95%CI: 1.14-2.09, P=0.005), long diameter of lymph node <20.0 mm (OR=2.03, 95%CI: 1.48-2.79, P<0.001), short diameter of lymph node <8.6 mm (OR=1.41, 95%CI: 1.06-1.89, P=0.019) and 1-2 suspicious lymph nodes (OR=2.74, 95%CI: 1.63-4.61, P<0.001) were independently associated with low nodal burden. The progesteron receptor status and the long diameter of lymph node were independent predictors of disease-free survival (HR=2.06, 95%CI: 1.21-3.50, P=0.008; HR=1.66，95%CI: 1.15-2.40, P=0.007) and overall survival (HR=4.53, 95%CI: 2.18~9.59, P<0.001; HR=3.49，95%CI:1.96-6.20, P<0.001). Conclusions Ultrasound features can help predict lymph nodal metastasis burden and prognosis of patients with clinical axillary node?positive breast cancer, and guide subsequent individualized treatment. Related Articles | Metrics

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Effects of extramedullary diseases and regulatory T cells on the treatment efficacy of chimeric antigen receptor T cells in multiple myeloma WANG Jia, ZHAI Zhimin, GE Jian, WANG Xingbing, DONG Yi 2022, 14 (4):  400-406.  doi: 10.3969/j.issn.1674-5671.2022.04.07 Abstract ( 232 )   PDF   Save Objective To investigate the effects of extramedullary diseases (EMD)and regulatory T cells (Tregs) on the treatment efficacy of B cell mature antigens (BCMA) chimeric antigen receptor T cells (CAR-T) in relapsed/refractory multiple myeloma (RRMM). Methods A total of 24 RRMM patients, who admitted to the Second Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University and the First Affiliated Hospital of the University of Science and Technology of China from June 2019 to September 2021, were selected as the research objects. The treatment response and toxicity were observed and monitored after BCMA-CAR-T cell infusion. The overall remission rate (ORR), duration of response (DOR), follow-up of relapse-free survival (RFS) and overall survival (OS) were compared between the patient groups with and without EMD as well as of high and low Tregs levels. Results Within 2 months of BCMA-CAR-T cell infusion, the ORR of RRMM patients was 87.5%. The ORR of patients without EMD was better than that of patients with EMD (P=0.038), and Tregs levels did not affect the ORR of patients (P=0.876); With EMD and the abnormal increase Tregs reduced the duration of remission ( P=0.004, 0.001).The OS rate and RFS rate of patients with EMD were lower than those without EMD (60.0% vs 84.2%, P=0.013; 40.0% vs 57.9%, P=0.007); The OS rate of patients with abnormally high Tregs level was not significantly different from that of patients with normal or low Tregs level (P=0.077), but the RFS rate was significantly decreased (40.0% vs 77.8%, P=0.011). Univariable Cox regression analysis showed that OS and RFS of patients with EMD were shorter than those without EMD (HR=8.465, 95%CI: 1.150-62.315, P=0.036; HR=5.569, 95%CI: 1.332-23.285, P=0.019), RFS of patients with abnormally high Tregs level was also shorter than that of patients with normal or low Tregs level (HR=8.806, 95%CI: 1.088-71.282, P=0.017). There was no significant difference in the incidence of overall adverse events in BCMA-CAR-T cell therapy between the EMD group and the Tregs group (all P>0.05). Conclusions The efficacy and survival of BCMA-CAR-T cell therapy are worse in RRMM patients with EMD than those without EMD, and abnormal Tregs may be the root causes of its recurrence. Related Articles | Metrics

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Predictive value of preoperative albumin to alkaline phosphatase ratio in the prognosis of patients after radical gastrectomy CHEN Minggan, GONG Qinghao, DAI Gang, ZHANG Meifeng, ZHANG Jie 2022, 14 (4):  407-411.  doi: 10.3969/j.issn.1674-5671.2022.04.08 Abstract ( 222 )   PDF   Save Objective To investigate the predictive value of preoperative albumin to alkaline phosphatase ratio (AAPR) in prognosis of patients after radical gastrectomy. Methods A total of 357 gastric cancer patients who underwent gastrectomy in Chongming Branch of Xinhua Hospital Affiliated to Medical College of Shanghai Jiao Tong University from June 2014 to November 2019 were retrospectively recruited as the research objects, and the follow-up was until December 2020. The optimal cut-off value of AAPR was calculated by the maximum selection rank statistics and the patients were divided into the high AAPR group and the low AAPR group. The Kaplan-Meier method and the Cox proportional hazards model were used to analyze the relationship between AAPR and disease-free survival (DFS) and overall survival (OS). The AAPR-TNM system was constructed by combining AAPR and TNM stage, and the predictive abilities of TNM staging system and AAPR-TNM system on DFS and OS were compared by the likelihood ratio test (LRT), AIC and C-index. Results The optimal cut-off value of AAPR was 0.412. 3-year DFS rate and OS rate of patients in the high AAPR group were higher than those in the low AAPR group (78.5% vs 38.1%, log-rank χ2=49.652, P<0.001; 87.2% vs 51.1%, log-rank χ2=33.532, P<0.001). After adjusting for potential confounding factors, high AAPR was a protective factor for DFS (HR=0.25, 95%CI: 0.15-0.42) and OS (HR=0.24, 95%CI: 0.13-0.39). Compared with the TNM staging system, the AAPR-TNM system had a larger LRT χ2 value, a smaller AIC and a higher C-index (all P<0.001). Conclusions The prognosis of gastric cancer patients with low preoperative AAPR level is poor after radical gastrectomy, and AAPR combined with TNM stage has better predictive ability than TNM staging system in postoperative prognosis. Related Articles | Metrics

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Development of a prognostic model for radical resection of locally⁃advanced oral squamous cell carcinoma LIN Xiaowan, LI Xiang, DU Chi 2022, 14 (4):  412-418.  doi: 10.3969/j.issn.1674?5671.2022.04.09 Abstract ( 172 )   PDF   Save Objective To develop and validate a model that can predict the prognosis of patients with locally-advanced oral squamous cell carcinoma (OSCC) after radical resection. Methods A total of 243 patients with primary locally-advanced OSCC who underwent radical resection in our hospital from February 2009 to January 2016 were retrospectively analyzed. Patients were randomly assigned to the training set (n=182) and the validation set (n=61). Cox regression was used to determine the independent factors that affect the overall survival (OS) in the training set, and to develop predictive 3-year and 5-year nomogram models and random survival forest (RSF) models. The performance of the predictive model was evaluated by receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis (DCA), and compared with the AJCC staging system. Results Cox regression showed that age, KFI index, pT stage, pN stage, AJCC stage, the number of positive lymph nodes, and SII were independent predictors of OS (all P<0.05). In the validation set, the AUC of RSF model, nomogram model, and AJCC staging system for predicting 3-year OS rate were 0.782, 0.756 and 0.703, respectively, for predicting 5-year OS rate were 0.780, 0.731 and 0.696, respectively. The calibration curve showed that the prediction models had a good consistency; the DCA curve showed that the clinical value of the nomogram model was higher than that of the AJCC staging system, while the clinical value of the RSF model was higher than that of the nomogram model. The log-rank test showed that the RSF model had good risk stratification ability (P<0.05). Conclusions The RFS model constructed based on age, KFI index, pT staging, pN staging, AJCC staging, number of positive lymph nodes and SII, can individually predict the prognosis of patients with locally-advanced OSCC after curative surgery. Related Articles | Metrics

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Changes and clinical significance of portal vein pressure after hemihepatectomy for hepato⁃cellular carcinoma#br# GONG Wenfeng, LU Zhan, ZHANG Jie, QI Lunan, CHEN Zushun, ZHONG Jianhong, LI Chuan, MA Liang, XIANG Bangde 2022, 14 (4):  419-423.  doi: 10.3969/j.issn.1674?5671.2022.04.10 Abstract ( 122 )   PDF   Save Objective To develop and validate a model that can predict the prognosis of patients with locally-advanced oral squamous cell carcinoma (OSCC) after radical resection. Methods A total of 243 patients with primary locally-advanced OSCC who underwent radical resection in our hospital from February 2009 to January 2016 were retrospectively analyzed. Patients were randomly assigned to the training set (n=182) and the validation set (n=61). Cox regression was used to determine the independent factors that affect the overall survival (OS) in the training set, and to develop predictive 3-year and 5-year nomogram models and random survival forest (RSF) models. The performance of the predictive model was evaluated by receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis (DCA), and compared with the AJCC staging system. Results Cox regression showed that age, KFI index, pT stage, pN stage, AJCC stage, the number of positive lymph nodes, and SII were independent predictors of OS (all P<0.05). In the validation set, the AUC of RSF model, nomogram model, and AJCC staging system for predicting 3-year OS rate were 0.782, 0.756 and 0.703, respectively, for predicting 5-year OS rate were 0.780, 0.731 and 0.696, respectively. The calibration curve showed that the prediction models had a good consistency; the DCA curve showed that the clinical value of the nomogram model was higher than that of the AJCC staging system, while the clinical value of the RSF model was higher than that of the nomogram model. The log-rank test showed that the RSF model had good risk stratification ability (P<0.05). Conclusions The RFS model constructed based on age, KFI index, pT staging, pN staging, AJCC staging, number of positive lymph nodes and SII, can individually predict the prognosis of patients with locally-advanced OSCC after curative surgery. Related Articles | Metrics

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Predictive value of tumor infiltrating lymphocyte in lymph node metastasis of cT1N0M0 breast cancer LAI Canhui, LUO Liyun, LIU Qi, LIN Zhimin, ZHANG Jiangling 2022, 14 (4):  424.  doi: 10.3969/j.issn.1674-5671.2022.04.11 Abstract ( 224 )   PDF   Save Objective To investigate the correlation between tumor-infiltrating lymphocyte (TIL) and lymph node metastasis in patients with cT1N0M0 breast cancer and the value of TIL density in predicting sentinel lymph node metastasis (SLNM). Methods The clinical data of patients with cT1N0M0 breast cancer who underwent surgery in our hospital from January 2008 to December 2016 were retrospectively analyzed. The histopathological assessment of TIL density was performed in the biopsy specimens before surgery. The multivariable logistic regression and the receiver operating characteristic (ROC) curve were used to analyze the value of TIL in predicting SLNM. Results A total of 153 patients with cT1N0M0 stage breast cancer were included in the analysis, of which 30 patients (19.6%) developed SLNM. The TIL density was related to estrogen receptor (ER) status (P<0.001), progesterone receptor (PgR) status (P=0.003), human epidermal growth factor receptor 2 (HER2) status (P=0.029), Ki67 expression (P=0.025), and nuclear grade (P=0.026). Multivariable logistic regression showed that TIL density (OR=1.40, 95%CI: 1.15-1.71, P=0.001) was an independent factor affecting SLNM in cT1N0M0 breast cancer , and its area under the ROC curve (AUC) was 0.755 (95%CI: 0.680-0.830, P<0.001). Conclusions TIL density is closely related to SLNM in cT1N0M0 breast cancer and may be a potential predictor of SLNM. Related Articles | Metrics

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Correlation between come beam breast computed tomography features and HER2 expression in non⁃mass enhancement breast cancer ZHONG Wuning, KANG Wei, WANG Zhonghai, ZHAO Xin, SU Danke 2022, 14 (4):  429-434.  doi: 10.3969/j.issn.1674-5671.2022.04.12 Abstract ( 156 )   PDF   Save Objective To summarize the best evidence for sexual health management of breast cancer patients with an evidence?based method, to provide reference for clinical practice. Methods The clinical practice guidelines, expert consensus and systematic reviews  on the management of sexual problems in breast cancer patients were collected through computer retrieval of websites and databases such as Guidelines International Network, Network National Guideline Clearinghouse, National Comprehensive Cancer Network, the Cochrane Library, PubMed, and the CNKI academic literature database, searched from 1 January 2011 to 23 May 2021. The quality of the literature was evaluated by 2 researchers, and the evidence was extracted and summarized. Results A total of 15 articles were included, including 1 clinical practice guide, 6 expert consensus, and 8 systematic reviews/Meta?analysis. After refinement, 21 pieces of best evidence were summarized, in terms of  patient evaluation, education/training, treatment and rehabilitation exercises. Conclusions  The oncology medical staff should properly carry out sexual problem assessment and sexual health knowledge training for breast cancer patients, actively carry out sexual health education for patients and their partners, and select appropriate intervention methods to improve the sexual health problems of breast cancer patients. Related Articles | Metrics

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Evidence for sexual health management of breast cancer patients QIU Lin, TONG Yang, JIN Yongmei 2022, 14 (4):  434-439.  doi: 10.3969/j.issn.1674-5671.2022.04.13 Abstract ( 208 )   PDF   Save Objective To summarize the best evidence for sexual health management of breast cancer patients with an evidence-based method, to provide reference for clinical practice. Methods The clinical practice guidelines, expert consensus and systematic reviews  on the management of sexual problems in breast cancer patients were collected through computer retrieval of websites and databases such as Guidelines International Network, Network National Guideline Clearinghouse, National Comprehensive Cancer Network, the Cochrane Library, PubMed, and the CNKI academic literature database, searched from 1 January 2011 to 23 May 2021. The quality of the literature was evaluated by 2 researchers, and the evidence was extracted and summarized. Results A total of 15 articles were included, including 1 clinical practice guide, 6 expert consensus, and 8 systematic reviews/Meta?analysis. After refinement, 21 pieces of best evidence were summarized, in terms of  patient evaluation, education/training, treatment and rehabilitation exercises. Conclusions  The oncology medical staff should properly carry out sexual problem assessment and sexual health knowledge training for breast cancer patients, actively carry out sexual health education for patients and their partners, and select appropriate intervention methods to improve the sexual health problems of breast cancer patients. Related Articles | Metrics

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Analysis of the current status and influencing factors of alexithymia in patients with thyroid cancer HUANG Yuanqi, LIANG Bo, ZHAO Xiaole, ZHANG Xiaodong, QIN Baoyu, LI Hong, LYU Ping 2022, 14 (4):  440-445.  doi: 10.3969/j.issn.1674-5671.2022.04.14 Abstract ( 232 )   PDF   Save Objective To investigate the current status of alexithymia cancer and analyze its influencing factors. Methods  A total of 194 thyroid cancer patients admitted to the First Affiliated Hospital of Guangxi Medical University's Integrated Thyroid Disease Diagnostic and Treatment Center from January 2021 to February 2022 were selected as the survey subjects. A questionnaire survey was conducted using the toronto alexithymia scale, body image scale and distress disclosure index scale, the patients were divided into the alexithymia group and the non?alexithymia group according to their alexithymia scores, and dichotomous logistic regression was used to analyze the influencing factors of alexithymia. Results The incidence of alexithymia among 194 thyroid cancer patients was 64.4%. The results of dichotomous logistic regression showed that female gender and body imagery disorders were risk factors for alexithymia (both P<0.05); the self-representation level was a protective factor for alexithymia (P<0.05). Conclusions The incidence of alexithymia in patients with thyroid cancer is relatively high, and special attention should be paid to women, patients with body imagery disorders, and patients with low levels of self?representation for targeted psychosocial interventions. Related Articles | Metrics

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The role of hepatitis B virus in the development of diffuse large B?cell lymphoma CHEN Hongsen, HE Yida, Li Zishuai, WANG Ruihua, CAO Guangwen 2022, 14 (4):  445-452.  doi: 10.3969/j.issn.1674-5671.2022.04.15 Abstract ( 255 )   PDF   Save Related Articles | Metrics

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Research progress of mitochondrial DNA genomic instability in hepatocellular carcinoma LIU Qiulong, XING Jinliang, GAO Yizhao, WANG Zhenni, ZHOU Kaixiang, ZHANG Zhaohui, ZHOU Feng, GUO Xu 2022, 14 (4):  452-456.  doi: 10.3969/j.issn.1674-5671.2022.04.16 Abstract ( 230 )   PDF   Save Related Articles | Metrics

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Research progress of Rho/ROCK signaling pathway in tumors CHEN Jinglian, WEI Xinjie, TANG Weizhong 2022, 14 (4):  457-463.  doi: 10.3969/j.issn.1674-5671.2022.04.17 Abstract ( 420 )   PDF   Save Related Articles | Metrics

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Research progress of EBV and PD-L1 in locally advanced nasopharyngeal carcinoma LUO Lihua, ZHANG Sijia, XIANG Donghua, YI Junlin 2022, 14 (4):  463-469.  doi: 10.3969/j.issn.1674-5671.2022.04.18 Abstract ( 238 )   PDF   Save Related Articles | Metrics

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Research progress on the mechanism and clinical application of microRNAs in hepatocellular carcinoma LIU Haotian, XU Jianfeng, PAN Lixin, WANG Qiuyan, XIANG Bangde, ZHONG Jianhong 2022, 14 (4):  470-475.  doi: 10.3969/j.issn.1674-5671.2022.04.19 Abstract ( 188 )   PDF   Save Related Articles | Metrics

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Research progress of imaging preoperative diagnosis of axillary metastatic lymph nodes in breast cancer ZHAO Xin, SU Danke 2022, 14 (4):  475-479.  doi: 10.3969/j.issn.1674-5671.2022.04.20 Abstract ( 251 )   PDF   Save Related Articles | Metrics