Table of Content

25 December 2022, Volume 14 Issue 6 Previous Issue    Next Issue

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Relationship between TIPIN and prognosis of hepatocellular carcinoma cells and its biological mechanism LU Rui, WEI Xuanjun, HU Longquan, ZHANG Le 2022, 14 (6):  600-606.  doi: 10.3969/j.issn.1674-5671.2022.06.01 Abstract ( 6130 )   PDF   Save Objective To analyze the expression of rhythmic molecules timeless interacting protein (TIPIN) in hepatocellular carcinoma (HCC) tissues and its relationship with the prognosis of patients, and to explore the effect of TIPIN on the proliferation of HCC cells and its possible biological mechanism. Methods The expression of TIPIN in HCC and its relationship with the prognosis of HCC patients were explored through the UALCAN database. The siTIPIN and its negative control sequence were transfected into liver cancer MHCC⁃97H cells, respectively, and the expression of TIPIN was detected by qRT⁃PCR and Western blot. The effect of TIPIN expression on cells proliferation was detected by the MTS assay and the plate cell clone formation assay. The GO and KEGG enrichment analysis of TIPIN and its association with Timeless (TIM) and TP53 were performed using UALCAN database. Results UALCAN database analysis showed that the expression of TIPIN in HCC tissues was significantly higher than that in normal liver tissues (P<0.01). The overall survival and disease⁃free survival in patients with high TIPIN expression were significantly lower than those of patients with low TIPIN expression (P=0.037, 0.021). Compared with normal liver cells HL7702, the mRNA and protein expression of TIPIN in MHCC⁃97H, MHCC⁃97L, HepG2 and BEL⁃7402 were significantly increased (all P<0.01). MTS and plate cell clonal formation experiments showed that the proliferation and clonogenesis of MHCC⁃97H cells were significantly inhibited after silencing the expression of TIPIN (all P<0.05). GO and KEGG analysis showed that TIPIN might promote the malignant process of HCC by regulating the interaction pathways of cell division, DNA replication and cell cycle. Pearson correlation analysis showed that TIPIN was positively correlated with TIM expression (r=0.67, P<0.01). The expression of TIPIN in TP53 mutant HCC patients was significantly higher than that in TP53 wild type HCC patients (P<0.01). Conclusions The expression of TIPIN is up⁃regulated in liver cancer and is closely related to poor prognosis. Silencing TIPIN can inhibit the proliferation of liver cancer cells. TIPIN may play a biological role in liver cancer cells by forming complex with TIM or regulating TP53 signal pathway. Related Articles | Metrics

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Saikosaponin d regulates autophagy in glioma C6 cells through the AKT/mTOR signaling pathway ZHANG Jing, YU Huiling, ZHAO Pengwei, YIN Huaxia, LIU Xiaoxi 2022, 14 (6):  606-610.  doi: 10.3969/j.issn.1674-5671.2022.06.02 Abstract ( 2309 )   PDF   Save Objective To investigate the role of saikosaponin d in the autophagy of glioma C6 cells and its mechanism. Method CCK⁃8 was used to detect the cell proliferation ability of the glioma C6 cells treated by saikosaponin d with final concentrations of 0 μmol/L (Control group), 2 μmol/L, 4 μmol/L, 6 μmol/L, 8 μmol/L, 10 μmol/L and 12 μmol/L, respectively. The effects of saikosaponin d with concentrations of 8 μmol/L on the proliferation and migration of glioma C6 cells were detected by clonal formation experiments and scratch experiments, respectively. Western blot and qRT⁃PCR were used to detect the expression of autophagy⁃related proteins Beclin1, LC3 and AKT/mTOR signaling pathway⁃related proteins and genes in glioma C6 cells. Results Compared with the Control group, all the other concentrations of saikosaponin d could inhibit the proliferation of glioma C6 cells, and the proliferation inhibition rate increased with the increase of drug concentration (all P<0.01). After the treatment of 8 μmol/L saikosaponin d for 24 h, compared with the Control group, the clone number of glioma C6 cells was significantly reduced (479.33±30.66 vs 258.66±73.35, P<0.01), the cell migration rate was significantly decreased ［(70.83±4.29) % vs (19.47±1.71) %, P<0.001］, and the protein and mRNA expression levels of autophagy⁃related proteins Beclin1 and LC3 were significantly increased (all P<0.01), while the protein and mRNA expression levels of AKT and mTOR were decreased (all P<0.01). Conclusions Saikosaponin d may induce autophagy, and inhibit the proliferation and migration of glioma C6 cells by inhibiting the AKT/mTOR signaling pathway. Related Articles | Metrics

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Effect of kinesin family member 23 on the proliferation and migration of colorectal cancer cells and its mechanism HUANG Yu, ZHOU Xianguo, LI Xueyu, WEI Liuting, CAO Ji, RONG Minhua 2022, 14 (6):  611-616.  doi: 10.3969/j.issn.1674-5671.2022.06.03 Abstract ( 101 )   PDF   Save Objective To investigate the expression of kinesin family member 23 (KIF23) in colorectal cancer, as well as its biological function and possible mechanism in colorectal cancer cells. Methods The cancer tissues and adjacent normal tissues from 20 colorectal cancer patients diagnosed and treated in Guangxi Medical University Cancer Hospital, from May 2021 to December 2021 were collected. The expression of KIF23 in colorectal cancer tissues was detected by RT⁃qPCR, its relationship with clinicopathological characteristics was analyzed, and the expression differences were verified by using an online database (TGGA，CCLE). KIF23 in human colorectal cancer RKO cells was silenced by using the siRNA transfection technology, cell proliferation and migration ability were detected by the CCK⁃8 assay, EDU proliferation assay, and Transwell migration assay. The expression levels of MDM2, p53, and p21 were detected by Western blot. Results The expression of KIF23 in colorectal cancer tissues was higher than that in adjacent normal tissues (P<0.0001), and the online database validation results showed the same trend (P<0.0001). Univariable analysis showed that expression level of KIF23 was correlated with tumor metastasis, CEA and CA199 levels (all P<0.05). The results of the vitro experiments showed that, compared with the siNC group, the proliferation and migration ability was significantly decreased in the siKIF23 group (all P<0.01), the protein expression levels of KIF23 and MDM2 were decreased (all P<0.01), and the protein expression levels of p53 and p21 were increased (all P<0.01). Conclusions KIF23 is highly expressed in colorectal cancer tissues, and may regulate malignant behaviors such as proliferation and migration of colorectal cancer cells through the MDM2⁃p53/p21 signaling pathway. Related Articles | Metrics

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miR⁃449a regulates proliferation and apoptosis of non⁃small cell lung cancer cells through NOTCH1⁃mediated ferroptosis JIA Xiaoqiong, SUN Qiuying, LIU Xiaoyu, WEN Zhenping 2022, 14 (6):  617-623.  doi: 10.3969/j.issn.1674-5671.2022.06.04 Abstract ( 2312 )   PDF   Save Objective To investigate the regulatory effect of miR⁃449a on the proliferation and apoptosis of non⁃small cell lung cancer cells and its molecular mechanism. Methods The miR⁃499a overexpression analogue Agomir⁃499a (Agomir⁃499a group) and its negative control (NC group) were transfected, respectively, into non⁃small cell lung cancer  NCI⁃H1975 cells. The expression level of miR⁃499a in transfected cells was detected by qRT⁃PCR, the cell proliferation was detected by CCK⁃8 and Ki67 staining, and the apoptosis was detected by Annexin V staining. NCI⁃H1975 cells transfected with Agomir⁃499a were treated with ferrostatin⁃1 (Fer⁃1) and glutathione (GSH), respectively (denoted as Agomir⁃499a + Fer⁃1 group and Agomir⁃499a+GSH group). The Fe2+ level and the content of GSH in cells was detected by the fluorescent probe and the optical colorimetry method, respectively. qRT⁃PCR was used to detect the mRNA expression of ferroptosis and iron homeostasis related genes, and Western blot was used to detect the expression of NOTCH1 signaling pathway related proteins. Results Compared with those in the NC group, the expression level of miR⁃499a in NCI⁃H1975 cells of the Agomir⁃449a group was significantly increased (P=0.001), the proliferation activity of NCI⁃H1975 cells was significantly decreased (P<0.05), and the proportion of cell apoptosis was significantly increased (P=0.004). The expression levels of ferroptosis⁃related factors PTGS2, ACSL4, SLC7A11 and COX2 , the proportion of Fe2+ positive cells, and the expressions levels of iron homeostasis⁃related genes TF, STEAP3, TFRC and DMT1 were significantly increased (all P<0.05). However, GSH content and expression levels of NOTCH1 signaling pathway related molecules NOTCH1, NICD, JAG1, JAG2, DLL1 and HES1 were significantly decreased (all P<0.05). Compared with the Agomir⁃449a group, the expression levels of ferroptosis⁃related factors PTGS2, ACSL4, SLC7A11 and COX2, the proportion of Fe2+ positive cells, and the expressions levels of iron homeostasis⁃related genes TF and STEAP3 in the Agomir⁃449a+Fer⁃1 group were significantly decreased (all P<0.05), while the GSH content and the expression levels of NOTCH1 signaling pathway related molecules NICD, JAG1 and DLL1 were significantly increased (all P<0.05). The expression levels of SLC7A11, COX2 and ACSL4 in the Agomir⁃449a+GSH group were also significantly lower than those in Agomir⁃449a group (all P<0.05). Conclusions The miR⁃449a can induce apoptosis and proliferation inhibition of non⁃small cell lung cancer NCI⁃H1975 cells, and its mechanism may be related to the inhibition of ferroptosis mediated by NOTCH1 signaling. Related Articles | Metrics

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Development and comparison of VX2 and human osteosarcoma MG⁃63 rabbits tumorigenesis model HE Qianqian, YANG Shaoling, ZHAO Kun, HU Jing, LIN Wenhua, ZHANG Hongzhen, GU Jiahong, HE Lan 2022, 14 (6):  624-630.  doi: 10.3969/j.issn.1674-5671.2022.06.05 Abstract ( 2238 )   PDF   Save Objective To investigate the feasibility of transplanting human osteosarcoma MG⁃63 tumor masses into rabbits tumorigenesis model. Methods A total of 24 New Zealand white rabbits were randomly divided into the VX2 group and the MG⁃63 group, with 12 rabbits in each group. VX2 tumor or human osteosarcoma MG⁃63 tumor were implanted into the bone marrow cavity of the right tibia of each rabbit in both groups. Color Doppler ultrasound was performed at 3, 4 and 5 weeks after modeling, and X⁃ray and CT exa⁃minations were performed at the end of the 4⁃week ultrasonography to observe the tumorigenic characteristics and tumorigenic rate of the rabbits in both groups. Alkaline phosphatase (AKP) levels were measured before and 4 weeks after modeling. At 3 and 4 weeks after modeling, 3 tumorous rabbits in each group were sacrificed by the air embolization method, and the remaining rabbits were sacrificed at 5 weeks after modeling for pathological examination. Results There were 10 and 11 rabbits surviving in the VX2 and MG⁃63 groups, respectively. The tumor formation rates were 60.0%, 90.0%, 100.0% in the VX2 group and 0, 45.5%, 63.6% in the MG⁃63 group at 1, 2, and 3 weeks after modeling, respectively. The lung metastasis rates were 66.7%, 66.7%, 100.0% in the VX2 group and 0, 33.3%, 40.0% in the MG⁃63 group at 3, 4, and 5 weeks after modeling, respectively. No abdominal organ metastasis was observed in all the examined rabbits. At 4 weeks after modeling, the serum AKP concentration in the VX2 group was significantly higher than that before modeling and the MG⁃63 group, the differences were statistically significant (P=0.002, <0.001). The results of radiographic and pathological examination showed that significant bone destruction occurred in the VX2 group and slight bone destruction occurred in the MG⁃63 group at 4 weeks after modeling. The rate of bone destruction and tumor bone formation in the VX2 group were higher than those in the MG⁃63 group, but the differences were not statistically significant (P=0.152, 0.072). Conclusions Compared with the rabbit VX2 tumor model, the tumor formation rate and lung metastasis rate of the MG⁃63 rabbit osteosarcoma model are lower, with poor stability. The ideal rabbit osteosarcoma animal model still needs to be further explored. Related Articles | Metrics

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Prognostic analysis of hepatocellular carcinoma based on characteristics of plasma cell⁃free DNA fragmentomics SONG Jian, YAN Zeyu, PENG Fan, XIE Fanfan, DONG Xiaotian, AN Jiaze 2022, 14 (6):  630-636.  doi: 10.3969/j.issn.1674-5671.2022.06.06 Abstract ( 2497 )   PDF   Save Objective To investigate  the value of plasma cell⁃free DNA (cfDNA) fragmentomics in the prognostic analysis of hepatocellular carcinoma (HCC). Methods A total of 50 HCC patients admitted to the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Fourth Military Medical University from June 2016 to September 2016 were selected as the subjects of study. Preoperative blood of HCC patients was collected for cfDNA extraction, library construction, and cfDNA sequencing. The cfDNA fragmentomic characteristics of HCC patients were analyzed, including fragment size distribution and terminal base motifs. The clinical data of patients combined with cfDNA fragmentomic data was performed by Cox regression analysis to screen independent factors affecting the prognosis of HCC patients, and a nomogram model was constructed to predict the overall survival rate of HCC patients. Results The cfDNA fragment sizes were mainly in the range of  150-200 bp, and the peak was at 167 bp; and continuous peak waves with an interval of about 10 bp appeared between 100-200 bp. Comparing the end motifs of total fragments, the differences were statistically significant (all P<0.001), except for the differences between the mean percentages of  A⁃end and G⁃end, and T⁃end and C⁃end (all P>0.05). Meanwhile, the differences between the mean proportion of each end motifs in the short fragments and the long fragments were also statistically significant (all P<0.001). The tumor differentiation, BCLC stage and fragment size score were independent factors affecting the prognosis of HCC patients(all P<0.05). Based on the above three factors to construct the nomogram model, the area under the receiver operating characteristic (ROC) curve for predicting  the 1⁃ and 3⁃year overall survival rate of HCC patients was 0.836 and 0.840, respectively. Conclusions  The combination of cfDNA fragmentomics and clinical indicators have great potential in the prognostic assessment of HCC.  Related Articles | Metrics

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Effect of preoperative alkaline phosphatase to prealbumin ratio on overall survival after hepatectomy LIANG Weikang, MO Qiuyan, ZHOU Xianguo, GONG Wenfeng, HUANG Qiongguang, LIN Qiuling, LIU Yingchun, QIU Moqin, LIANG Xiumei, CHEN Peiqin, ZHOU Yunxiang, WEI Xueyan, LONG Meiying, 2022, 14 (6):  637-642.  doi: 10.3969/j.issn.1674-5671.2022.06.07 Abstract ( 2308 )   PDF   Save Objective To investigate the effect of preoperative alkaline phosphatase to prealbumin ratio (APR) on overall survival (OS) of hepatocellular carcinoma (HCC) patients after hepatectomy. Methods The clinical data of 942 HCC patients who underwent hepatectomy in the Guangxi Medical University Cancer Hospital from January 2012 to December 2016 were retrospectively analyzed. The cut⁃off value of APR was determined by time⁃dependent receiver operating characteristic (ROC) curve.  According to the cut⁃off value, patients were divided into high APR group (APR≥cut⁃off value) and low APR group (APR Results The ROC curves showed that the area under the curve (AUC) of APR for predicting the prognosis of HCC patients at 5 years after surgery was 0.656, and the cut⁃off value of APR was 0.38 U/mg. The 1⁃, 3⁃, and 5⁃year overall survival rates of the low APR group were 90.3%, 75.5%, and 69.5%, respectively, and those of the high APR group were 76.5%, 54.5%, and 46.0%, respectively, the difference between the two groups was statistically significant (P<0.001). Multivariable Cox proportional hazards regression model analysis showed that high APR was an independent risk factor for OS in HCC patients after hepatectomy (HR=1.646, 95%CI: 1.323-2.047, P<0.001). Conclusions Preoperative high APR is an independent risk factor for prognosis of HCC patients after hepatectomy, and may be a predictor of poor prognosis in HCC patients after hepatectomy. Related Articles | Metrics

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Comparison of clinical efficacy of icotinib and gefitinib in the treatment of EGFR⁃mutated advanced lung adenocarcinoma WU Lili, ZHU Yingli, ZHUO Xiaolu, HUANG Lina, YE Dong 2022, 14 (6):  642-646.  doi: 10.3969/j.issn.1674-5671.2022.06.08 Abstract ( 2421 )   PDF   Save Objective To compare the clinical efficacy, adverse events, and immunological function status after medication of icotinib and gefitinib in the treatment of advanced lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutations. Methods A total of 176 patients with EGFR mutation⁃positive lung adenocarcinoma confirmed by pathological biopsy at Guangxi Medical University Cancer Hospital from January 2012 to December 2019 were selected as the objects of study, and divided into the icotinib group and gefitinib group according to the targeted treatment regimen. The treatment efficacy were evaluated according to the RECIST 1.1 standard. The incidence of adverse reactions, differences of cellular immunity and humoral immunity indexes were compared between the two groups. Results There was no significant difference between icotinib and gefitinib in terms of objective response rate (60.0% vs 63.2%), disease control rate (94.0% vs 92.1%), median progression⁃free survival (9.5 months vs 8.9 months), median overall survival (21.7 months vs 18.5 months ) as well as overall incidence of adverse reactions (31.0% vs 34.2%) (all P>0.05) . There was no significant difference of cellular immune indicators (CD3+T cells, CD4+T cells, CD8+T cells, CD4+/CD8+, natural killer cells) and humoral immune indicator IgM between two groups (all P>0.05). However, the levels of humoral immune indicators IgG and IgA in gefitinib group were higher than those of icotinib group (all P<0.05). Conclusions The clinical efficacy and adverse events of icotinib and gefitinib are similar in the treatment of advanced lung adenocarcinoma patients with EGFR mutation⁃positive. The cellular immune functions of the two groups are also similar, but the levels of humoral IgG and IgA in gefitinib group are slightly higher than those in icotinib group. Related Articles | Metrics

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Clinical study of intraoperative contrast⁃assisted resection of glioma with low⁃dose sodium fluorescein LIANG Xi, LING Guoyuan, DENG Teng, MO Ligen 2022, 14 (6):  647-652.  doi: 10.3969/j.issn.1674-5671.2022.06.09 Abstract ( 2242 )   PDF   Save Objective  To investigate the clinical efficacy of intraoperative contrast⁃assisted resection of glioma with low⁃dose sodium fluorescein. Methods The clinical data of 100 patients with glioma who underwent surgical treatment in the Department of Neurosurgery, Guangxi Medical University Cancer Hospital from October 2018 to January 2021 were retrospectively analyzed. The patients were divided into the observation and the control groups according to different surgical methods, by which 47 patients in the observation group underwent microsurgical glioma resection under the guidance of low⁃dose sodium fluorescein (1 mg/kg), and 53 patients in the control group underwent glioma resection under the conventional microscope. The two groups were compared with respect to total resection rate, Karnofsky score (KPS score) at 3 months postoperatively, operative time, intraoperative bleeding, and postoperative complications. Results The surgery was successfully completed in both groups, and the total resection rate in the observation group was 80.9%, which was significantly higher than 58.5% in the control group (P=0.028). After correcting for possible confounding factors, the total resection rate of the observation group was 6.94 times higher than that of the control group (OR=6.94, 95%CI: 1.96-24.65, P=0.003); the KPS score of the observation group at 3 months after surgery was 7.94 points higher than of the control group (β=7.94, P=0.037). There was no significant differences in the mean operative time and median intraoperative bleeding between the two groups (all P>0.05). The main complications in both groups were intracranial infection and postoperative bleeding, and the incidence was not significantly different (all P>0.05). Conclusions Compared with conventional microscopic glioma resection, microscopic resection under low⁃dose sodium fluorescein guidance can improve the total resection rate of gliomas and improve the postoperative life quality of patients. Related Articles | Metrics

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Primary ovarian diffuse large B⁃cell lymphoma: 4 cases report and literature review ZHANG Xuefang, DIAO Xiaoli, WANG Shuzhen 2022, 14 (6):  653-658.  doi: 10.3969/j.issn.1674-5671.2022.06.10 Abstract ( 2271 )   PDF   Save  Objective To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of primary ovarian diffuse large B⁃cell lymphoma (PODLBCL). Methods The clinical data of 4 patients with PODLBCL admitted to Beijing Chao⁃yang Hospital, Capital Medical University from January 2003 to January 2021 were retrospectively analyzed and the literature was reviewed. Results The 4 cases of PODLBCL patients were diagnosed by postoperative histopathology. The main clinical symptoms were pelvic masses and abdominal pain; 2 cases with B symptoms, 2 cases with bilateral ovarian tumors, 2 cases with unilateral tumors (both occurred in the right ovary) and 3 cases with high expression of CA125 and lactate dehydrogenase (LDH). Microscopically, the normal ovary was destroyed and diffusely infiltrated by relatively single and large lymphocytes. The cytoplasm was usually basophilic, and the nucleus was round or oval, with single or multiple nucleoli; mitotic figures were common, and CD20 staining was positive. The treatment included surgery, chemotherapy and monoclonal antibody treatment. After 2-238 months of follow⁃up, 3 patients survived without recurrence and 1 patient died. Conclusions PODLBCL is a rare diffuse large B⁃cell lymphoma with no specific clinical manifestation. The diagnosis depends on postoperative histopathology, and the prognosis is good. Chemotherapy combined with monoclonal antibody therapy may be the first⁃line treatment option to avoid surgery, but a definitive diagnosis before surgery is critical. Related Articles | Metrics

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Summary of the best evidence for non⁃pharmacological intervention in breast cancer patients with osteoporosis MA Jingyi, DONG Xuefan, TIAN Jianli, LI Yang, SHI Limin 2022, 14 (6):  659-664.  doi: 10.3969/j.issn.1674-5671.2022.06.11 Abstract ( 2366 )   PDF   Save Objective To search, extract and summarize the latest evidence of non⁃pharmacological intervention for osteoporosis in breast cancer patients. Methods The literatures on non⁃pharmacological for osteoporosis in breast cancer patients were searched from UpToDate, BMJ, JBI, International Guideline Collaboration Network, British National Osteoporosis Guideline Group, Cochrane, PubMed, Yimaitong, China National Knowledge Infrastructure, Wanfang and other websites and databases. The search period was from January 1, 2017 to November 8, 2022. Two researchers independently evaluated the quality of the literatures. Results A total of 14 literatures were included, including 4 clinical decisions, 4 guidelines, 5 expert consensuses and 1 systematic review. Finally, 25 pieces of best evidence were summarized based on the screening and evaluation of osteoporosis in breast cancer patients, non⁃pharmacological interventions and precautions. Conclusions The evidence of non⁃pharmacological intervention of osteoporosis in breast cancer patients is helpful for medical care personnel to carry out bone health management, and provides an evidence⁃based for guiding the non⁃pharmacological management of osteoporosis in breast cancer patients. Related Articles | Metrics

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Interaction between hepatitis B virus and mitochondria and its impact on the evolution of hepatocellular carcinoma ZHU Xiaoqiong, LIU Wenbin, ZHAO Pei, LIN Jiansheng, WANG Ruihua, YU Hongping, ZHAO Cunxi, CAO Guangwen 2022, 14 (6):  665-671.  doi: 10.3969/j.issn.1674-5671.2022.06.12 Abstract ( 2954 )   PDF   Save Related Articles | Metrics

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Research progress on the effect of non⁃coding RNA on epithelial mesenchymal transition in cervical cancer QI Ding, LI Hongmei, WANG Shuoqi, HU Xijiao, HAN Buwei, LIU Ning, ZHENG Rui, LIU Li 2022, 14 (6):  671-676.  doi: 10.3969/j.issn.1674-5671.2022.06.13 Abstract ( 2208 )   PDF   Save Related Articles | Metrics

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Research progress on the role of CD200 in malignant tumors  DONG Yinan, JIA Peiqi 2022, 14 (6):  677-681.  doi: 10.3969/j.issn.1674-5671.2022.06.14 Abstract ( 2427 )   PDF   Save Related Articles | Metrics

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Advances in the regulatory pathway of ferroptosis and its research in tumor radiotherapy and immunotherapy resistance WANG Tingan, WU Liucheng, WEI Weiyuan, LING Tong, HUANG Mingwei, QIN Yuzhou 2022, 14 (6):  682-686.  doi: 10.3969/j.issn.1674-5671.2022.06.15 Abstract ( 278 )   PDF   Save Related Articles | Metrics

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Advances in radiation therapy combined with immune checkpoint inhibitors in the treatment of radiation⁃immune⁃associated pneumonia in lung cancer CHENG Chao, LI Jie 2022, 14 (6):  687-692.  doi: 10.3969/j.issn.1674-5671.2022.06.16 Abstract ( 2329 )   PDF   Save Related Articles | Metrics

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Research progress of vibutuximab in the treatment of lymphoma LI Jie, ZHANG Yong, ZHANG Yue, ZHANG Juan, ZHOU Hebing 2022, 14 (6):  693-697.  doi: 10.3969/j.issn.1674-5671.2022.06.17 Abstract ( 2419 )   PDF   Save Related Articles | Metrics