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Chinese Journal of Oncology Prevention and Treatment

Table of Content

    25 June 2023, Volume 15 Issue 3 Previous Issue    Next Issue
    CONTENTS IN BRIEF
    2023, 15 (3):  0-0. 
    Abstract ( 106 )   PDF (3919KB) ( 68 )   Save
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    Chinese expert consensus on clinical diagnosis and treatment of tumor with unknown primary focus based on molecular guidance， 2023
    Tumor Marker Committee of Chinese Anti-cancer Association, Chongqing Medical Association Precision Medicine and Molecular Diagnosis Branch, Tumor Marker Committee of Chongqing Anti-cancer Association Basic Research
    2023, 15 (3):  252-262.  doi: 10.3969/j.issn.1674-5671.2023.03.02
    Abstract ( 311 )   PDF   Save
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    The role and mechanism of piR-hsa-130912 in promoting proliferation,invasion and migration ofepithelial ovarian cancer cells
    CHEN Xiaoqi, ZHAO Bingbing, LI Zhuang, FENG Yanying, YANG Zhijun
    2023, 15 (3):  263-271.  doi: 10.3969/j.issn.1674-5671.2023.03.03
    Abstract ( 216 )   PDF   Save
    Objective To investigate the role of piR⁃hsa⁃130912 on the proliferation, invasion and migration of epithelial ovarian cancer(EOC) cells  and its molecular mechanism. Methods BGISEQ UMI Small RNA sequencing and RT⁃qPCR were performed to identify piR⁃hsa⁃130912 in EOC tissues. LV⁃piR⁃hsa⁃130912⁃up, piR⁃hsa⁃130912⁃inhibitor and corresponding negative control virus were used to infect EOC cells A2780 and SKOV3 and interfere with the expression level of piR⁃hsa⁃130912. Cell proliferation was detected by CCK⁃8 and clone formation assays. Cells invasion and migration abilities were determined by Transwell assay and wound healing experiment. Western blot was used to examine the expression of tumor metastasis⁃related proteins zeb⁃1, E⁃cadherin and vimentin. The mechanism of piR⁃hsa⁃130912 regulating cell proliferation, invasion and migration was preliminarily explored by combining RNA sequencing, GSEA analysis, KEGG and GO analyses. Results BGISEQ UMI Small RNA sequencing and RT⁃qPCR results confirmed that piR⁃hsa⁃130912 was highly expressed in EOC tissues. Compared to the corresponding negative control group, overexpression of piR⁃hsa⁃130912 enhanced the proliferation, invasion and migration of A2780 and SKOV3 cells (all P<0.05), and promoted the protein expression of zeb⁃1 and vimentin in A2780 cells (P=0.020, 0.017), while inhibited the expression of E⁃cadherin (P<0.001). Additionally, inhibition of piR⁃hsa⁃130912 expression weakened the proliferation, invasion, and migration abilities of A2780 and SKOV3 cells (all P<0.05), and promoted the expression of E⁃cadherin in SKOV3 cells (P=0.005), while inhibited the expression of vimentin (P=0.015). Moreover, piR⁃hsa⁃130912 could be involved in the regulation of arachidonic acid metabolism, linoleic acid metabolism, MAPK signaling pathway and receptor tyrosine kinase. Conclusions piR⁃hsa⁃130912 could promote the proliferation, invasion and migration of EOC cells, and its mechanism may be related to the regulation of lipid metabolism, MAPK and other tumor⁃related signaling pathways.
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     Overexpression of nuclear apoptosis-inducing factor 1 enhances the radiosensitivity of nasopharyngeal carcinoma cells
    CHEN Xuxia, YANG Xiaohui, CHEN Weiling, ZHOU Yufei, LI Kaiguo, QU Song
    2023, 15 (3):  272-277.  doi: 10.3969/j.issn.1674-5671.2023.03.04
    Abstract ( 164 )   PDF   Save
    bjective To investigate the effect of nuclear apoptosis⁃inducing factor 1 (NAIF1) on the radiosensitivity of nasopharyngeal carcinoma (NPC) CNE⁃2R cells. Methods The expression levels of NAIF1 in NPC CNE⁃2 and CNE⁃2R cells were detected by Western blot. CNE⁃2R cells were infected with overexpressed NAIF1 lentivirus (LV⁃NAIF1 group) and its negative control lentivirus (LV⁃NC group) respectively. The mRNA and protein expression levels of NAIF1 were detected by RT⁃qPCR and Western blot. The CCK⁃8 assay and colony formation assay were performed to evaluate the proliferation and colony formation ability in each group of cells under different doses of irradiation (0, 2, 4, 6, 8 Gy) and the corresponding survival fractions were calculated. The cell cycle distributions of cells before and after exposure to 6 Gy of X⁃ray in each group were analyzed by flow cytometry. Results Compared with CNE⁃2 cells, the protein expression level of NAIF1 was significantly decreased in CNE⁃2R cells (P<0.001). Compared with the LV⁃NC group, the mRNA and protein expression levels of NAIF1 in CNE⁃2R cells were significantly increased in the LV⁃NAIF1 group (all P<0.001). After different doses of irradiation, overexpressed NAIF1 inhibited the proliferation ability of CNE⁃2R cells (P<0.05), and significantly decreased the colony formation number and survival fraction of CNE⁃2R cells (P<0.05). After irradiation with 6 Gy, compared with the LV⁃NC group, overexpressed NAIF1 made more CNE⁃2R cells arrest in the G2/M phase which was the most radiosensitive phase of a cell cycle (P<0.01).   Conclusions NAIF1 is down⁃regulated in NPC CNE⁃2R cells. The overexpression of NAIF1 may enhance the radiosensitivity of NPC CNE⁃2R cells by inhibiting cell proliferation and arresting the cell cycle at the G2/M phase.
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    Berberine induces ferroptosis in prostate cancer cells and its mechanisms
    MU Kefei, YE Jiwei, SHENG Yuanjing, ZHANG Sai, GUO Xinwu
    2023, 15 (3):  278-284.  doi: 10.3969/j.issn.1674-5671.2023.03.05
    Abstract ( 270 )   PDF   Save
    Objective To investigate the effect of berberine on ferroptosis in prostate cancer cells and its mechanism. Methods Prostate cancer DU145 and PC⁃3 cells were cultured in vitro, and the effects of berberine with different concentrations (1.560, 3.125, 6.250, 12.500, 25.000, 50.000, 100.000 μmol/L) on the proliferation ability of prostate cancer cells were evaluated by CCK⁃8 assay, and the half⁃inhibitory concentration (IC50) were calculated. The levels of glutathione (GSH), cysteine, reactive oxygen species (ROS), and Fe2+ in both DU145 and PC⁃3 cells were determined by GSH detection assay kit, cysteine assay kit, DCFH⁃DA fluorescent probe assay, and the fluorescent probe, respectively. qRT⁃PCR was performed to detect the expression levels of ferroptosis⁃related genes (GPX4, COX2, FTH1 and SLC7A11). Results Berberine at various concentrations inhibited the proliferation abilities of DU145 and PC⁃3 cells in a concentration⁃dependent way (all P<0.05) , with IC50 values of 19.94 μmol/L and 20.18 μmol/L, respectively. The ferroptosis inhibitor Ferrostatin1 (Fer⁃1) reversed the inhibitory effect of berberine (20 μmol/L) on cell proliferation in DU145 and PC⁃3 cells (all P<0.001), whereas cell apoptosis and pyroptosis inhibitors could not restore cell viability. Treatment with berberine at the concentration of 20 μmol/L significantly decreased the levels of GSH and cysteine in DU145 and PC⁃3 cells (all P<0.001), and increased the levels of lipid ROS and Fe2+ (all P<0.001). However, the Fer⁃1 could reverse berberine⁃induced intracellular lipid ROS level and Fe2+ level (all P<0.001), and restored the levels of GSH and cysteine (all P<0.001). In addition, berberine significantly down⁃regulated the expression levels of SLC7A11 and GPX4 in DU145 and PC⁃3 cells (all P<0.05), while up⁃regulated the expression levels of COX2 and FTH1 (all P<0.01). Overexpression of SLC7A11 reversed the promotive effect of berberine on ferroptosis in prostate cancer cells (all P<0.001). Conclusions Berberine promotes intracellular lipid ROS accumulation and up⁃regulation of Fe2+ levels in prostate cancer cells by inhibiting SLC7A11 expression to induce ferroptosis.
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    Dictamnine inhibits proliferation and induces autophage and apoptosis by targeting PI3K/KEAP1 signaling  in ovarian cancer cells
    LÜ Sihui, LIANG Jinlan, DENG Mingjing, LIU Yingzhao, WANG Qi
    2023, 15 (3):  285-291.  doi: 10.3969/j.issn.1674-5671.2023.03.06
    Abstract ( 194 )   PDF   Save
    Objective To investigate the effect of Dictamnine on proliferation, apoptosis and autophagy of ovarian cancer cells and its mechanism. Methods Human ovarian cancer cell lines (A2780, PA⁃1) and human normal ovarian epithelial cell lines (IOSE80) were treated with Dictamnine of different concentrations (0, 32, 65, 125, 250 μmol/L), and the IC50 values of each cell were detected by CCK⁃8 assay. The core targets of Dictamnine for ovarian cancer were screened out by network pharmacology, and molecular docking was used to assess the binding ability. A2780 cells were selected and treated with Dictamnine (0, 50, 75 μmol/L). The effects of Dictamnine on cell proliferation, apoptosis and autophagy of A2780 cells were analyzed by CCK⁃8 assay, HE staining, Annexin V⁃FITC/PI double staining and Western blot. The effect of Dictamnine on the growth of ovarian cancer grafts in nude mice was observed. The tissue morphology and ultrastructure of the grafts were observed by HE staining and transmission electron microscopy (TEM), and the expression levels of Cleaved PARP and Ki67 in the grafts were detected by immunohistochemical staining (IHC). Results The results of CCK⁃8 assay showed that the IC50 of Dictamnine on A2780 cells and PA⁃1 cells were significantly lower than those of IOSE80 cells, with the strongest inhibitory effect on A2780 cells. The proliferation ability of A2780 cells in Dictamnine (50 μmol/L, 75 μmol/L) treatment groups was significantly decreased compared with untreated cells (all P<0.05). The ten core targets of Dictamnine against ovarian cancer were screened by network pharmacology, and the targets with strong binding ability were PIK3CD, KEAP1 and AHR. Flow cytometry results showed a significant increase in apoptosis rate in A2780 cells after treatment with Dictamnine for 48 h and 72 h (all P<0.01).Western blot analysis showed that compared with the untreated group, the expression levels of A2780 cells apoptosis⁃related proteins Cleaved PARP and PARP were significantly increased, the expression levels of autophagy⁃related proteins SQSTM1/p62 and KEAP1 were decreased, the ratio of LC3B Ⅱ/Ⅰ expression levels were increased, and expression levels of PI3K signaling pathway protein PI3K was decreased (all P<0.05). After Dictamnine treatment, the volume of transplanted tumors in nude mice decreased significantly (P=0.0053), tumor tissue showed obvious apoptotic cells under TEM, and IHC results showed a decrease in Ki67 expression level and an increase in Cleaved PARP expression level (all P<0.001). HE staining demonstrated that Dictamnine⁃treated A2780 cells exhibited a short spindle⁃shaped or ovoid⁃shaped with reduced volume, and the apoptotic/necrotic cells were present in grafts. Conclusions Dictamnine probably inhibit proliferation of ovarian cancer cells and induce autophagy and apoptosis by targeting the PI3K/KEAP1 signaling pathway.
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    Bisdemethoxycurcumin induces apoptosis and inhibits proliferation of non-small cell lung cancer cells by regulating HIF-1α-mediated senescence
    LIU Huaying, XIA Xue, ZHANG Mengwei, LUO Qinqin
    2023, 15 (3):  291-297.  doi: 10.3969/j.issn.1674-5671.2023.03.07
    Abstract ( 194 )   PDF   Save
    Objective To investigate the regulatory effect of dimethoxycurcumin (BDMC) on the proliferation and apoptosis in non⁃small cell lung cancer cells and its mechanism. Methods Non⁃small cell lung cancer cell lines NCI⁃H1975 and NCI⁃H520 were treated with phosphate buffered saline (PBS) and 20 μmol/L BDMC. Cell viability was detected by CCK⁃8; cell proliferation was detected by carboxyfluorescein diacetate succinimide ester (CFSE); cell apoptosis was detected by acridine orange (AO) and Annexin V⁃FITC/PI staining; senescence⁃associated β⁃galactosidase (SA⁃β⁃Gal) staining assay was used to detect the activity of SA⁃β⁃Gal; the proportion of  SA⁃β⁃Gal positive cells was detected by flow cytometer. Subsequently, NCI⁃H1975 and NCI⁃H520 cells were treated with 20 μmol/L BDMC, 20 μmol/L hypoxia inducible factor⁃1α (HIF⁃1α) inhibitor PX⁃478, or a combination of both, respectively, and the cells treated with PBS served as the control group. The expression of HIF⁃1α and HIF⁃2α proteins was detected by Western blot , and the activity of SA⁃β⁃Gal was detected by SA⁃β⁃Gal staining assay. Results Compared with the PBS group, the cell viability of NCI⁃H1975 and NCI⁃H520 in BDMC group was significantly reduced (all P<0.05), the proportion of CFSE⁃positive proliferating cells was significantly reduced (all P<0.01), the number of AO⁃positive cells was significantly decreased (all P<0.01), the proportions of Annexin V+PI- cells and SA⁃β⁃Gal+PI- cells were significantly increased (all P<0.01), the SA⁃β⁃Gal activity was significantly increased (all P<0.001), the protein expression of HIF⁃1α was significantly increased (all P<0.001). Compared with BDMC group, the protein expression of HIF⁃1α in BDMC+PX⁃478 group were decreased (P<0.05), as well as the proportion of SA⁃β⁃Gal⁃positive cells. Conclusions BDMC may promote senescence of non⁃small cell lung cancer cells by up⁃regulating HIF⁃1α signaling pathway, and thus inhibit cell proliferation and promote apoptosis.
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    Inhibitory effect of compound cremastra appendiculata on growth of human breast cancer MDA-MB-231 cell xenografts in nude mice and a network pharmacological analysis
    WU Lingjun, LIANG Cong, HUANG Ju, LI Jialin, HUANG Songling, CHEN Zhuying, HE Ping
    2023, 15 (3):  298-303.  doi: 10.3969/j.issn.1674-5671.2023.03.08
    Abstract ( 183 )   PDF   Save
    Objective To investigate the inhibitory effect of compound cremastra appendiculata on the growth of human breast cancer MDA⁃MB⁃231 cell xenografts in nude mice and its potential mechanism. Methods The nude mice of model human breast cancer MDA⁃MB⁃231 cell xenografts were randomly divided into model group, doxorubicin (DOX) group, compound cremastra appendiculata ethanol extraction (CCAEE) high⁃dose group (1.8 g/kg) and CCAEE low⁃dose group (0.9 g/kg), with 5 mice in each group. After 21 days of continuous drug administration, the nude mice were sacrificed, and the tumor volume, tumor weight and tumor inhibition rate were calculated. The effective components of compound cremastra appendiculata and their corresponding targets were selected from the TCMSP 2.3 database, and the key targets were screened from the OMIM, GeneCards 5.14, DrugBank 5.1.10 and TTD databases.The protein⁃protein interaction (PPI) network of key targets was constructed by STRING 11.5 database. Then, the core targets were screened to establish the "drug⁃component⁃target" network and screen the core effective components. GO and KEGG enrichment analyses were performed using the Metascape 3.5 platform. Results Compared with the model group, after the 21 days treatment, the tumor volume and weight of the nude mice in DOX group, CCAEE high⁃dose group and low⁃dose group were significantly reduced (all P<0.05), and the tumor inhibition rates were 89.67%, 67.39% and 43.48%, respectively. 27 effective ingredients of compound cremastra appendiculata and 108 key targets for against breast cancer were obtained through a network pharmacological analysis, including 23 core targets (TP53, MAPK3, MAPK1, RELA, AKT1, FOS, ESR1, TNF, IL6, MAPK14, etc.) and 5 core  effective components (quercetin, kaempferol, β⁃sitosterol, 2⁃methoxy⁃9, 10⁃dihydro⁃4, 5⁃diol, and deoxypodophyllotoxin). GO and KEGG enrichment analyses indicated that compound cremastra appendiculata showed its anti⁃breast cancer effect mainly through the regulation of the biological processes such as hormone regulation and the signaling pathways such as PI3K⁃AKT and MAPK. Conclusions Compound cremastra appendiculata can inhibit the growth of human breast cancer xenograft, probably by acting on core targets such as TP53 and signaling pathways such as PI3K⁃AKT and MAPK through core effective ingredients such as quercetin and kaempferol.

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    Epidemiological characteristics and the trend of disease burden of leukemia in children aged 0-14 years in Guangxi cancer registry areas,2015-2019
    LI Qiulin, YU Jiahua, RONG Minhua, ZHOU Zihan, CAO Ji, GE Lianying, YU Hongping, LIU Liang
    2023, 15 (3):  304-310.  doi: 10.3969/j.issn.1674-5671.2023.03.09
    Abstract ( 183 )   PDF   Save
    Objective To analyze the level and trend of the disease burden of leukemia among children aged 0-14 in the Guangxi cancer registry areas from 2015 to 2019, to understand the current situation of the leukemia burden in children in Guangxi, and provide evidence for the prevention and control of childhood cancer. Methods According to the incidence and death data of childhood leukemia from 2015 to 2019 reported by Guangxi cancer registry areas, the incidence rate, the mortality rate, the age⁃standardized rate by Chinese standard population census in 2000 (ASRC) and Segi´ s world standard population (ASRW) of childhood leukemia were calculated based on gender, age, and region to assess the incidence and mortality of childhood leukemia. Furthermore, the years of life lost (YLLs), the years of lived with disability (YLDs) and the disability⁃adjusted life years (DALYs) were calculated to analyze the disease burden of childhood leukemia. The Joinpoint regression model was use to calculate the annual percentage change (APC) of childhood leukemia incidence rate and mortality, and evaluate the change trends. Results From 2015 to 2019, a total of 295 new cases of childhood leukemia were reported in the Guangxi cancer registry areas, with an incidence rate of 3.86/105, ASRC of 3.58/105, ASRW of 3.93/105 (In urban areas, the incidence rate was 4.25/105 and the ASRC was 3.99/105; in rural areas, the incidence rate was 3.37/105 and the ASRC was 3.09/105). A total of 136 cases died of childhood leukemia were reported, with a mortality rate of 1.78/105, ASRC of 1.74/105, ASRW of 1.79/105 (In urban areas, the mortality rate was 1.70/105 and the ASRC was 1.70/105; in rural areas, the mortality rate was 1.87/105 and the ASRC was 1.79/105). From 2015 to 2019, the incidence rate of childhood leukemia in the Guangxi cancer registry areas showed a downward trend (APC=-5.79%, P=0.29), but the change was not statistically significant. However, the downward change of mortality was significant (APC=-9.95%, P=0.03). The trends of incidence and mortality rates of leukemia in male and female children were generally consistent with the overall trend. The DALYs caused by leukemia in children aged 0-14 years old were 4,255.48 person⁃years, with a DALYs rate of 55.65/105, among which the DALYs rate was 63.86/105 in the group aged 0-4 years and 51.14/105 in the group aged 5-14 years.The incidence rate, mortality and DALYs of leukemia in male children were higher than those in female children. Conclusions From 2015 to 2019, the incidence rate, mortality and DALYs rate of childhood leukemia in the Guangxi cancer registry area showed a general downward trend. The disease burden of leukemia in male children are higher than those in female, and in the rural areas are higher than in the urban areas. The focus of concern should be on children aged 0-4 years.
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    Analysis of fusion gene expression and clinical characteristics in 341 children with acute lymphoblastic leukemia
    LI Ning, DING Luyue, LIU Wei, WANG Tianyou
    2023, 15 (3):  311-316.  doi: 10.3969/j.issn.1674-5671.2023.03.10
    Abstract ( 206 )   PDF   Save
    Objective To investigate the expression of fusion genes and clinical characteristics in children with acute lymphoblastic leukemia (ALL). Methods The clinical data of 341 newly diagnosed ALL children patients admitted to Henan Children's Hospital from January 2018 to December 2021 were enrolled and retrospectively analyzed. The patients were divided into positive group and negative group according to the detection of fusion genes, and the clinical characteristics, complete response rate, recurrence rate and mortality as well as other indicators were compared among different groups. Results The positive detection rate of fusion genes in 341 children with ALL was 48.1% (164/341), with a total of 15 fusion genes were detected, including TEL⁃AML1, KMT2A rearrangement, E2A⁃PBX1, BCR⁃ABL1, MEF2D rearrangement, SIL⁃TAL1, etc. There was a statistically significant difference in fusion gene expression among different age groups (P<0.001) , with KMT2A rearrangement and MEF2D rearrangement more common in the <1 years old group and the >10 years old group, respectively. Hyperleukopenia was more common in children with KMT2A rearrangement+, BCR⁃ABL1+, MEF2D rearrangement+ and SIL⁃TAL1+, and the children patients with latter three types were more prone to central nervous system involvement. KMT2A rearrangement (P<0.001), BCR⁃ABL1 (P=0.001), and MEF2D rearrangement (P=0.001) were more common in the high⁃risk patients. The detection rate of gene mutation in the fusion gene positive group was significantly lower than that in the negative group (27.9% vs 53.6%, P<0.001). The Ph⁃like gene was only detected in children with acute B⁃lymphocytic leukemia, and the highest detection rate was found in the IK6 subtype, with 40% (8/20) of the IK6 subtype associated with BCR⁃ABL1. In the evaluation on the 33rd day and the 12th week of treatment, the complete remission rate of minimal residual desease (MRD) detected by polymerase chain reaction in BCR⁃ABL1+ ALL patients was lower than that of MRD detected by flow cytometry at the corresponding time point (P<0.05). The recurrence rate of the fusion gene positive group was significantly higher than that of the negative group (P<0.001), while there was no statistically significant difference in mortality between the two groups (P=0.080). The highest recurrence and mortality were observed in the KMT2A rearrangement+ group. Conclusions Children with newly diagnosed ALL exhibit significant differences in clinical characteristics, treatment response rate, recurrence rate, and mortality. Monitoring MRD during treatment is an important basis for assessing risk stratification and predicting prognosis.
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    The value of the ratio of pre-operative platelet distribution width to tumor size in the prognosis of  patients with non-metastatic lung adenocarcinoma
    ZHAO Guangqiang, XUE Tianhui, YAN Bing
    2023, 15 (3):  317-321.  doi: 10.3969/j.issn.1674-5671.2023.03.11
    Abstract ( 154 )   PDF   Save
    Objective To investigate the predictive value of pre⁃operative platelet distribution width (PDW) to tumor size (TS) ratio (PdwTR) on the disease⁃free survival (DFS) in non⁃metastatic lung adenocarcinoma patients. Methods A total of 198 patients of non⁃metastatic lung adenocarcinoma diagnosed pathologically after surgical treatment were collected in Hainan Hospital of PLA General Hospital from December 2012 to December 2020. The patients were divided into low PdwTR group and high PdwTR group, according to the optimal cut⁃off value of PdwTR determined by receiver operating characteristic (ROC) curve. The effectiveness of PdwTR, PDW and TS in predicting DFS was evaluated by time⁃dependent ROC curve, and the association between PdwTR and DFS was analyzed by Cox proportional hazard model. Results The optimal cut⁃off point of PdwTR was 7.45, the sensitivity and specificity of PdwTR for 3⁃year DFS were 93.90% and 61.20%, respectively. In addition, the area under ROC curve for PdwTR was 0.83 (95%CI: 0.75-0.90). The results of log⁃rank test showed that the DFS of low PdwTR group was lower than that of high PdwTR group (log⁃rank χ2=28.99, P<0.001). After the adjustment for potential confounding factors such as age, gender, BMI, CEA level, T stage, N stage, TNM stage, NLR, LMR, and PNI by Cox regression model, the high PdwTR group showed a 93.0% decrease in the risk of recurrence compared to the low PdwTR group (HR=0.07, 95%CI: 0.02-0.33, P=0.001). Conclusions  Low preoperative PdwTR is independently associated with poor DFS in patients with non⁃metastatic lung adenocarcinoma, and can be used as a predictor of DFS.
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     Influencing factors of quality of life in patients with advanced non-small cell lung cancer
    GONG Jingjie, ZHANG Haibo, YANG Yi, CAO Jiayu, DING Nan, ZHAO Jun
    2023, 15 (3):  322-327.  doi: 10.3969/j.issn.1674-5671.2023.03.12
    Abstract ( 188 )   PDF   Save
    Objective To investigate the influencing factors of quality of life in patients with advanced non⁃small cell lung cancer(NSCLC). Method A total of 205 patients with advanced NSCLC admitted to the oncology, respiratory, and geriatric oncology departments of the First Affiliated Hospital of Nanjing Medical University from June 2021 to August 2022 were selected. EORTC QLQ⁃C30 version 3.0 Chinese version and the lung cancer supplement module QLQ⁃LC13 were used to evaluate the patients' quality of life. The multiple linear regression analysis was performed with general data as the independent variable and scores in various fields of the quality of life scale as the dependent variable. Results Among the QLQ⁃C30 scores in various fields, the score of patient's social function ［66.67 (IQR: 50.00,83.33)］ was the lowest, and fatigue symptom ［33.33 (IQR: 11.11,33.33)］ was the highest; Among the QLQ⁃LC13 scores in various fields, the score of patients with shortness of breath symptoms ［33.33 (IQR: 0.00,33.33)］ scored was the highest. Age was a influencing factor of emotional function and symptoms on cough and insomnia(P<0.05); gender was a factor affecting emotional function(P<0.05); family economic status was the influence factor of physical function, role function, general health status, and economic difficulties(P<0.05). Clinical stage was the influence factor of role function, social function, general health status, economic difficulties, diarrhea symptoms(P<0.05), and hand and shoulder pain symptoms(P<0.05). The duration of disease was a factor affectting physical function and role function(P<0.05); smoking history was a factor in general health status, insomnia symptoms, cough symptoms, and other local pain symptoms(P<0.05). Although the patients treated with chemotherapy combined with targeted therapy had fewer other pain symptoms, diarrhea symptoms were more severe (P<0.05). Conclusions The quality of life of patients with advanced NSCLC is influenced by multiple factors. Patients who are female, young, have poor family conditions, have a short disease duration, high clinical stage, inability to work, and have a history of smoking should be given more attention and personalized support to improve their quality of life.
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    Research progress of copper and its compounds in anti-tumor therapy
    LIN Qian, FAN Huiming, ZOU You, CHEN Shiming
    2023, 15 (3):  328-334.  doi: 10.3969/j.issn.1674-5671.2023.03.13
    Abstract ( 249 )   PDF   Save
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    Research progress of ferroptosis in prostate cancer#br#
    LI Jia, YANG Jin, LIANG Guobiao, CHEN Lin
    2023, 15 (3):  334-339.  doi: 10.3969/j.issn.1674-5671.2023.03.14
    Abstract ( 203 )   PDF   Save
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     Research progress of dietary alkylresorcinols in cancer prevention
    FAN Wan, WANG Jian, BAI Jinshan, ZHANG Jinfeng, LI Linlin, ZHAO Shaohui, YANG Jun, YANG Chun
    2023, 15 (3):  349-353.  doi: 10.3969/j.issn.1674-5671.2023.03.17
    Abstract ( 160 )   PDF   PDF（mobile） (358KB) ( 13 )   Save

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    Primary malignant melanoma of the cervix diagnosed by thinprep cytologic: a case report 
    ZHAO Chunmei, WANG Yan, KUI Xiang, GUO Minmin, OU Zhiyan, KE Yang
    2023, 15 (3):  359-360.  doi: 10.3969/j.issn.1674-5671.2023.03.19
    Abstract ( 145 )   PDF   Save
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