Abstract: Objective To investigate the influencing factors of quality of life in patients with advanced non⁃small cell lung cancer(NSCLC). Method A total of 205 patients with advanced NSCLC admitted to the oncology, respiratory, and geriatric oncology departments of the First Affiliated Hospital of Nanjing Medical University from June 2021 to August 2022 were selected. EORTC QLQ⁃C30 version 3.0 Chinese version and the lung cancer supplement module QLQ⁃LC13 were used to evaluate the patients' quality of life. The multiple linear regression analysis was performed with general data as the independent variable and scores in various fields of the quality of life scale as the dependent variable. Results Among the QLQ⁃C30 scores in various fields, the score of patient's social function ［66.67 (IQR: 50.00,83.33)］ was the lowest, and fatigue symptom ［33.33 (IQR: 11.11,33.33)］ was the highest; Among the QLQ⁃LC13 scores in various fields, the score of patients with shortness of breath symptoms ［33.33 (IQR: 0.00,33.33)］ scored was the highest. Age was a influencing factor of emotional function and symptoms on cough and insomnia(P<0.05); gender was a factor affecting emotional function(P<0.05); family economic status was the influence factor of physical function, role function, general health status, and economic difficulties(P<0.05). Clinical stage was the influence factor of role function, social function, general health status, economic difficulties, diarrhea symptoms(P<0.05), and hand and shoulder pain symptoms(P<0.05). The duration of disease was a factor affectting physical function and role function(P<0.05); smoking history was a factor in general health status, insomnia symptoms, cough symptoms, and other local pain symptoms(P<0.05). Although the patients treated with chemotherapy combined with targeted therapy had fewer other pain symptoms, diarrhea symptoms were more severe (P<0.05). Conclusions The quality of life of patients with advanced NSCLC is influenced by multiple factors. Patients who are female, young, have poor family conditions, have a short disease duration, high clinical stage, inability to work, and have a history of smoking should be given more attention and personalized support to improve their quality of life.

Key words:  Non?small cell lung cancer, Quality of life, Influencing factors, Regression analysis