关键词:  , 血管内皮抑制素, 血管内皮生长因子, 小鼠, 腹水, 抑制

Abstract: Objective To investigate the effect of intraperitoneal endostar administration to treat H22 ascites in mice. Methods A mouse model of ascites was established by inoculating 110 Kunming mice with H22 cells（2×106，i.p. injection）.Mice were then di-vided randomly into 5 groups:control （normal saline）；low endostar dose（4 mg/kg•day），intermediate endostar dose（8 mg/kg•day）， high endostar dose（12 mg/kg•day）and positive control（DDP 0.6 mg/kg•day）.After an adjustment period of 24h，the groups were treated from day 1 to day 10 by i.p. injection as indicated above and sacrificed 24h after drug withdrawal.Data were collected on vol-ume of ascitic fluid，metastases of abdominal organs and lungs and survival time.Peritoneal membrane permeability was assessed us-ing Evan blue staining. Results Intermediate and high doses of endostar significantly inhibited the production of ascites in H22 as-citesbearing mice，reduced the frequency of metastases in the abdominal viscera and lungs，and lengthened average survival time. Conclusion Intraperitoneal administration of endostar can reduce ascites in H22 ascites-bearing mice.

Key words: Endostar, Vascular endothelial growth factor, Mice, Ascites