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中国癌症防治杂志

中国癌症防治杂志

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5-氟尿嘧啶缓释剂在肝细胞性肝癌根治性切除术中植入预防复发的研究

张志明;赵荫农;刘剑勇;吴飞翔;向邦德;黄山;黎乐群;袁卫平;   

  1. 广西医科大学肿瘤医院肝胆外科;
  • 收稿日期:2010-09-25 修回日期:2010-09-25 出版日期:2010-09-25 发布日期:2010-09-25

Effect of intraoperative implantation of slow-releasing 5-FU microparticles for preventing recurrence of hepatocellular carcinoma after curative resection

ZHANG Zhi-Ming,ZHAO Yin-nong,LIU Jian-Yong,et al.   

  1. (Department of Hepatobiliary Surgery,Affiliated Cancer Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2010-09-25 Revised:2010-09-25 Online:2010-09-25 Published:2010-09-25

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被引次数

21

摘要： 目的探讨肝细胞性肝癌根治性切除术中植入5-氟尿嘧啶缓释剂对患者复发率的影响。方法对2007年1月至2010年1月本院行肝癌切除术的250例患者分为植入组(125例)和对照组(125例),植入组术中植入5-Fu缓释微粒;对照组行常规肝切除术。对比分析两组患者术后1、2、3年的累积复发率。结果植入组1、2、3年的累积复发率分别为13.9%、31.9%、58.8%;对照组1、2、3年的累积复发率分别为30.9%、40.9%、70.9%,两组比较差异有统计学意义(P<0.05)。结论术中植入5-氟尿嘧啶缓释剂可降低肝细胞性肝癌患者术后复发率。

关键词: 肝细胞性肝癌, 5-氟尿嘧啶缓释剂, 复发

Abstract: Objective To evaluate the efficacy of intraoperative implantation of slow-releasing 5-FU microparticles for preventing local recurrence of hepatocellular carcinoma (HCC) after curative resection.MethodsA total of 250 patients with HCC underwent curative resection from Jan 2007 to Jan 2010 was included in this study.The patients were randomly divided into 5-FU microparticles implantation group and control group.The 125 patients in implantation group were treated with hepatectomy plus implanting slow-releasing 5-FU microparticles on the wound surface,whereas the 125 patients in control group were treated with hepatectomy alone.All the patients were followed up regularly.ResultsThe recurrent rates of 1-,2-and 3-year after operation were 13.9%,31.9% and 58.8% respectively in implantation group,while they were 30.9%,40.9% and 70.9% respectively in control group.The differences between the two groups were statistically significant (P<0.05).ConclusionsIntraoperative implantation of slow-releasing 5-FU microparticles on the wound surface is an effective measure to prevent local recurrence of HCC after curative resection.

Key words: Hepatocellular carcinoma, Slow-releasing 5-FU microparticles, Recurrence