微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (3): 203-206.doi: 10.3969/j.issn.1674-5671.2011.03.06

• 基础研究 • 上一篇    下一篇

广西南宁地区妇女子宫颈HPV感染型别的分析

高琨, 李力, 杨梅   

  1. 广西医科大学附属肿瘤医院妇瘤科；广西南宁市妇幼保健院
  • 出版日期:2011-09-25 发布日期:2011-10-17
  • 通讯作者: 李力 E-mail:lili@gxmu.edu.cn
  • 基金资助:

    广西壮族自治区科技厅项目（桂科攻10124001A-34）

Subtype analysis of human papillomavirus among the cervix-infected women in Nanning area of Guangxi

GAO Kun, LI Li, YANG Mei   

  • Online:2011-09-25 Published:2011-10-17

PDF (PC)

702

赞

被引次数

12

摘要： 目的 分析广西南宁地区妇女子宫颈HPV 感染类型，研究其分布的规律。方法 采用基因芯片法对1 250名门诊机会性筛查的妇女按自愿原则采用HPV基因分型检测。结果 HPV-DNA检测阳性者占31.36%（392/1 250）。HPV-DNA亚型以低危型感染为主，感染率由高到低排列为6、11、43型；高危亚型感染率由高到低排列为16、58、52、18。HPV高危亚型以单一型别感染为主，其次为单一低危亚型感染。在多重感染中以低危和高危型别的二重混合感染为主；而三重、四重感染少见。感染者年龄≤25岁者占42.35%，其次为25~34岁。结论 HPV感染亚型分布有一定的区域性，该检测可用于宫颈癌的筛查，以确定感染型别，有利于预测病变转归，指导临床治疗和随访。

关键词: 宫颈肿瘤, 人乳头瘤病毒, 基因分型

Abstract: Objective To analyze the situation and distribution of cervical human papillomavirus (HPV) infection among women in Nanning area of Guangxi. Methods Through clinic opportunistic screening，1 250 women received HPV genotypes test with gene chip technology. Result The positive rate of HPV DNA was 31.36%(392/1250).The major infected subtypes were the low-risk ones，and the descending order of prevalence was subtype 6，11 and 43. The descending order of prevalence among the high-risk subtypes was 16，58，52 and 18. Single high-risk subtype infection was common，followed by single low-risk subtype infection.Among the multiple-subtype infections，double infection with low-and high-risk subtype was common，while triple or quadruple infection was rare.Women aged ≤25 years old accounted for 42.35% of infection，followed by 25 to 34 years old. Conclusions Distribution of HPV subtypes is regional. Detection of HPV subtypes will help to predict the outcome of infection，guide clinical treatment and follow-up.

Key words: Cervix neoplasms, Human papillomavirus, Genotype