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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (4): 306-309.doi: 10.3969/j.issn.1674-5671.2011.04.10

• 临床研究 • 上一篇    下一篇

VEGF-C、COX-2在细支气管肺泡癌中的表达及其意义

邹亮, 高慧淳, 周建洪, 冯琼   

  1. 南昌大学第三附属医院病理科；南昌大学第二附属医院病理科
  • 出版日期:2011-12-25 发布日期:2012-01-20
  • 通讯作者: 冯琼 E-mail:ucgyi@126.com
  • 基金资助:

    江西省科技厅支撑计划项目(编号：2009BSB11108)

Expression of VEGF-C and COX-2 in bronchioalveolar carcinoma and its significance

ZOU Liang, GAO Hui-Chun, ZHOU Jian-Hong, FENG Qiong   

  • Online:2011-12-25 Published:2012-01-20

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被引次数

10

摘要： 目的 探讨细支气管肺泡癌（BAC）中VEGF-C、COX-2蛋白表达及意义。方法 BAC 60例为实验组，肺腺癌伴BAC 20例和肺腺癌22例为对照组，采用免疫组化法分别检测VEGF-C、COX-2蛋白在3种组织中的表达并分析其临床意义。结果 VEGF-C在BAC、肺腺癌伴BAC和肺腺癌中阳性率分别为66.7%、90.0%和95.5%，各组间表达差异有统计学意义（P＜0.05）；VEGF-C在BAC非黏液型表达阳性率显著高于黏液型（P＜0.05），伴淋巴结转移组阳性率明显高于无转移组（P＜0.05），VEGF-C表达与性别、年龄、肿块部位、大小及TNM分期均无关联（P＞0.05）。COX-2在BAC、肺腺癌伴BAC和肺腺癌中阳性率分别为63.3%、75.0%和77.3%，各组间表达差异无统计学意义（P ＞0.05）；COX-2在BAC伴淋巴结转移组表达阳性率明显高于无转移组（P＜0.05），肿块直径≥3cm组阳性率明显高于肿块直径＜3cm组（P＜0.05），COX-2表达与性别、年龄、肿块部位、病理类型及TNM分期均无关（P＞0.05）。VEGF-C与COX-2表达呈正相关（r=0.269，P＜0.05）。 结论 VEGF-C联合COX-2检测可用于BAC侵袭、转移特性的评估及预测。

关键词: 细支气管肺泡癌, COX-2, VEGF-C, 转移

Abstract: Objective To investigate the expression and clinical significance of VEGF-C and COX-2 in bronchioalveolar carcinoma (BAC). Methods 60 cases of BAC were enrolled in experimental group；the control group contained 20 cases of pulmonary adenocarcinoma with BAC features and 22 cases of pulmonary adenocarcinoma. Expressions of VEGF-C and COX-2 were detected by immunohistochemical. Results Positive rates of VEGF-C in BAC，pulmonary adenocarcinoma with BAC features and pulmonary adenocarcinoma were 66.7%，90.0% and 95.5% respectively，the difference of which was statistically significant (P＜0.01). The positive rates of VEGF-C were notably higher in non-mucinous BAC than that in mucinous (P＜0.01)，and in lymphonode metastasis than in that without lymphonode metastases (P＜0.05). The positive rate of VEGF-C was not correlated with patients’ gender and age，and the localization，size and TNM stage of tumor (P＞0.05).  Positive rates of COX-2 in BAC，pulmonary adenocarcinoma with BAC features and pulmonary adenocarcinoma were 63.3%，75.0% and 77.3% respectively，the difference of which was not statistically significant (P＞0.05). The positive rates of COX-2 were obviously higher in lymphonode metastasis than that without lymphonode metastases (P＜0.05)，in tumor with diameter >3cm than that with diameter <3cm (P＜0.05). The positive rate of COX-2 was not correlated with patients’ gender and age，and the localization，size，histological type and TNM stage of tumor (P＞0.05).The expression of VEGF-C was positively correlated with that of COX-2 (r=0.269，P＜0.05). Conclusion Combined detection of VEGF-C and COX-2 could be applied in assessing and predicting the invasion and metastasis of BAC.

Key words: Bronchioalveolar carcinoma, COX-2, VEGF-C, Metastasis